GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:15366706
| Citation |
Van Haastert, PJ and Devreotes, PN (2004) Chemotaxis: signalling the way forward. Nat. Rev. Mol. Cell Biol. 5:626-34 |
|---|---|
| Abstract |
During random locomotion, human neutrophils and Dictyostelium discoideum amoebae repeatedly extend and retract cytoplasmic processes. During directed cell migration--chemotaxis--these pseudopodia form predominantly at the leading edge in response to the local accumulation of certain signalling molecules. Concurrent changes in actin and myosin enable the cell to move towards the stimulus. Recent studies are beginning to identify an intricate network of signalling molecules that mediate these processes, and how these molecules become localized in the cell is now becoming clear. |
| Links |
PubMed Online version:10.1038/nrm1435 |
| Keywords |
Actins/physiology; Animals; Chemotaxis/physiology; Chemotaxis, Leukocyte/physiology; Cytoskeleton/physiology; Heterotrimeric GTP-Binding Proteins/physiology; Humans; Models, Biological; Neutrophils/physiology; Signal Transduction/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
