DICDI:ERK2

Species (Taxon ID)	Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s)	erkB (synonyms: dagC, erk2)
Protein Name(s)	Extracellular signal-regulated kinase 2 ERK2 Defective in aggregation protein C MAP kinase 2
External Links
UniProt	Q54QB1
EMBL	L33043 AAFI02000058
PIR	A56492
RefSeq	XP_638833.1
ProteinModelPortal	Q54QB1
IntAct	Q54QB1
STRING	44689.DDB0191457
PRIDE	Q54QB1
EnsemblProtists	DDB0191457
GeneID	8624357
KEGG	ddi:DDB_G0283903
dictyBase	DDB_G0283903
eggNOG	COG0515
InParanoid	Q54QB1
KO	K08293
OMA	LHGHENI
PhylomeDB	Q54QB1
PRO	PR:Q54QB1
Proteomes	UP000002195 UP000002195
GO	GO:0005829 GO:0005524 GO:0016301 GO:0004707 GO:0007190 GO:0031152 GO:0019933 GO:0051301 GO:0006935 GO:0007067 GO:0051344 GO:0030819 GO:0072718 GO:0032496
InterPro	IPR011009 IPR003527 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004713	protein tyrosine kinase activity	PMID:9164876^[1]	ECO:0000314			F		Figure 2 cAMP-induced tyrosine phosphorylation of ERK2 in Ax2 cells	complete CACAO 11007
involved_in	GO:0046777	protein autophosphorylation	PMID:7844154^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905301	regulation of macropinocytosis	PMID:29440238^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0051593)	Seeded From UniProt	complete
involved_in	GO:1903013	response to differentiation-inducing factor 1	PMID:25518940^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:20079430^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20079430^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044671	sorocarp spore cell differentiation	PMID:8557190^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007166	cell surface receptor signaling pathway	PMID:8631932^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(UniProtKB:P13773) happens_during:(GO:0051591)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007190	activation of adenylate cyclase activity	PMID:9295311^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0051593)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043326	chemotaxis to folate	PMID:9427685^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043327	chemotaxis to cAMP	PMID:9427685^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:8557190^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P15270)\|has_regulation_target:(UniProtKB:Q54YG2)	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:9164876^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019933	cAMP-mediated signaling	PMID:7844154^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007190	activation of adenylate cyclase activity	PMID:7844154^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0051591)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031152	aggregation involved in sorocarp development	PMID:7844154^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:7844154^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	PMID:9295311^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0051593)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072718	response to cisplatin	PMID:21300429^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity	PMID:15131307^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q23917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:21527280^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019933	cAMP-mediated signaling	PMID:15131307^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005634	nucleus	PMID:8670837^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000622871 UniProtKB:Q8ILF0 UniProtKB:Q8TD08	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004707	P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004707	P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004707	P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004707	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15473840^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kosaka, C & Pears, CJ (1997) Chemoattractants induce tyrosine phosphorylation of ERK2 in Dictyostelium discoideum by diverse signalling pathways. Biochem. J. 324 ( Pt 1) 347-52 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Segall, JE et al. (1995) A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol. 128 405-13 PubMed GONUTS page
↑ Williams, TD & Kay, RR (2018) The physiological regulation of macropinocytosis during growth and development. J. Cell. Sci. 131 PubMed GONUTS page
↑ Sugden, C et al. (2015) The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes. Mol. Biol. Cell 26 805-20 PubMed GONUTS page
↑ ^5.0 ^5.1 Nguyen, HN et al. (2010) MAP kinases have different functions in Dictyostelium G protein-mediated signaling. Cell. Signal. 22 836-47 PubMed GONUTS page
↑ ^6.0 ^6.1 Gaskins, C et al. (1996) The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways. Genes Dev. 10 118-28 PubMed GONUTS page
↑ Maeda, M et al. (1996) Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins. J. Biol. Chem. 271 3351-4 PubMed GONUTS page
↑ ^8.0 ^8.1 Maeda, M & Firtel, RA (1997) Activation of the mitogen-activated protein kinase ERK2 by the chemoattractant folic acid in Dictyostelium. J. Biol. Chem. 272 23690-5 PubMed GONUTS page
↑ ^9.0 ^9.1 Wang, Y et al. (1998) MAP kinase function in amoeboid chemotaxis. J. Cell. Sci. 111 ( Pt 3) 373-83 PubMed GONUTS page
↑ Moncho-Amor, V et al. (2011) The dual-specificity protein phosphatase MkpB, homologous to mammalian MKP phosphatases, is required for D. discoideum post-aggregative development and cisplatin response. Differentiation 81 199-207 PubMed GONUTS page
↑ ^11.0 ^11.1 Maeda, M et al. (2004) Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA. Science 304 875-8 PubMed GONUTS page
↑ Walk, A et al. (2011) Lipopolysaccharide enhances bactericidal activity in Dictyostelium discoideum cells. Dev. Comp. Immunol. 35 850-6 PubMed GONUTS page
↑ Knetsch, ML et al. (1996) Dual role of cAMP and involvement of both G-proteins and ras in regulation of ERK2 in Dictyostelium discoideum. EMBO J. 15 3361-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Manahan, CL et al. (2004) Chemoattractant signaling in dictyostelium discoideum. Annu. Rev. Cell Dev. Biol. 20 223-53 PubMed GONUTS page

[PMID:9164876-1] 1.0 ^1.1 Kosaka, C & Pears, CJ (1997) Chemoattractants induce tyrosine phosphorylation of ERK2 in Dictyostelium discoideum by diverse signalling pathways. Biochem. J. 324 ( Pt 1) 347-52 PubMed GONUTS page

[PMID:7844154-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Segall, JE et al. (1995) A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol. 128 405-13 PubMed GONUTS page

[PMID:29440238-3] Williams, TD & Kay, RR (2018) The physiological regulation of macropinocytosis during growth and development. J. Cell. Sci. 131 PubMed GONUTS page

[PMID:25518940-4] Sugden, C et al. (2015) The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes. Mol. Biol. Cell 26 805-20 PubMed GONUTS page

[PMID:20079430-5] 5.0 ^5.1 Nguyen, HN et al. (2010) MAP kinases have different functions in Dictyostelium G protein-mediated signaling. Cell. Signal. 22 836-47 PubMed GONUTS page

[PMID:8557190-6] 6.0 ^6.1 Gaskins, C et al. (1996) The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways. Genes Dev. 10 118-28 PubMed GONUTS page

[PMID:8631932-7] Maeda, M et al. (1996) Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins. J. Biol. Chem. 271 3351-4 PubMed GONUTS page

[PMID:9295311-8] 8.0 ^8.1 Maeda, M & Firtel, RA (1997) Activation of the mitogen-activated protein kinase ERK2 by the chemoattractant folic acid in Dictyostelium. J. Biol. Chem. 272 23690-5 PubMed GONUTS page

[PMID:9427685-9] 9.0 ^9.1 Wang, Y et al. (1998) MAP kinase function in amoeboid chemotaxis. J. Cell. Sci. 111 ( Pt 3) 373-83 PubMed GONUTS page

[PMID:21300429-10] Moncho-Amor, V et al. (2011) The dual-specificity protein phosphatase MkpB, homologous to mammalian MKP phosphatases, is required for D. discoideum post-aggregative development and cisplatin response. Differentiation 81 199-207 PubMed GONUTS page

[PMID:15131307-11] 11.0 ^11.1 Maeda, M et al. (2004) Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA. Science 304 875-8 PubMed GONUTS page

[PMID:21527280-12] Walk, A et al. (2011) Lipopolysaccharide enhances bactericidal activity in Dictyostelium discoideum cells. Dev. Comp. Immunol. 35 850-6 PubMed GONUTS page

[PMID:8670837-13] Knetsch, ML et al. (1996) Dual role of cAMP and involvement of both G-proteins and ras in regulation of ERK2 in Dictyostelium discoideum. EMBO J. 15 3361-8 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15473840-15] Manahan, CL et al. (2004) Chemoattractant signaling in dictyostelium discoideum. Annu. Rev. Cell Dev. Biol. 20 223-53 PubMed GONUTS page

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DICDI:ERK2

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