DANRE:VANG2

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	vangl2 (ECO:0000312 with ZFIN:ZDB-GENE-020507-3)
Protein Name(s)	Vang-like protein 2 Protein strabismus Protein trilobite Van Gogh-like protein 2
External Links
UniProt	Q8UVJ6
EMBL	AF428249 BC065983
RefSeq	NP_705960.1
UniGene	Dr.91583
BioGrid	79765
STRING	7955.ENSDARP00000031546
Ensembl	ENSDART00000033316
GeneID	245949
KEGG	dre:245949
CTD	57216
ZFIN	ZDB-GENE-020507-3
eggNOG	NOG268286
GeneTree	ENSGT00390000012496
HOGENOM	HOG000230590
HOVERGEN	HBG058215
InParanoid	Q8UVJ6
KO	K04510
OMA	MWHRESD
OrthoDB	EOG7MSMNR
PhylomeDB	Q8UVJ6
TreeFam	TF313467
Reactome	REACT_202432 REACT_223798
NextBio	20797201
PRO	PR:Q8UVJ6
Proteomes	UP000000437
Bgee	Q8UVJ6
GO	GO:0016021 GO:0005886 GO:0003401 GO:0060070 GO:0021535 GO:0042074 GO:0000902 GO:0044782 GO:0035844 GO:0060026 GO:0060027 GO:0048048 GO:0030010 GO:0000132 GO:0001736 GO:0007163 GO:0001654 GO:0060972 GO:0097475 GO:0014812 GO:0001839 GO:0021915 GO:0001841 GO:0001764 GO:0030903 GO:0045813 GO:0036342 GO:0030111 GO:0001756 GO:0055002 GO:0060071
InterPro	IPR009539
PANTHER	PTHR20886
Pfam	PF06638
PIRSF	PIRSF007991

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:12105418^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:11780127^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:12874125^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q6WGK5	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:9808788^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q90Z52	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:9007230^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:9007236^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:10992326^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060026	convergent extension	PMID:17239849^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q90Z52	P	Seeded From UniProt	complete
involved_in	GO:0045813	positive regulation of Wnt signaling pathway, calcium modulating pathway	PMID:11780127^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030903	notochord development	PMID:9007234^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:11780127^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	PMID:16407953^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:11780127^[2]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007163	establishment or maintenance of cell polarity	PMID:12105418^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q90X64	C	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:12874125^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q6WGK5	P	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:12105418^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:11820812^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	PMID:10996075^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q90Z52	P	Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:9808788^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q90Z52	P	Seeded From UniProt	complete
involved_in	GO:0097475	motor neuron migration	PMID:23821037^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-131003-7 ZFIN:ZDB-MRPHLNO-131003-5	P	Seeded From UniProt	complete
involved_in	GO:0097475	motor neuron migration	PMID:23988578^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1495	P	Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	PMID:27955617^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
involved_in	GO:0060972	left/right pattern formation	PMID:20643117^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2 ZFIN:ZDB-MRPHLNO-080918-2	P	Seeded From UniProt	complete
involved_in	GO:0060972	left/right pattern formation	PMID:20643117^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
involved_in	GO:0060972	left/right pattern formation	PMID:20305649^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-110823-3	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:27571019^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-021217-3	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:20643117^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2 ZFIN:ZDB-MRPHLNO-080918-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:20643117^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:23821037^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-131003-4 ZFIN:ZDB-MRPHLNO-131003-5	P	Seeded From UniProt	complete
involved_in	GO:0060030	dorsal convergence	PMID:9007234^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-263	P	Seeded From UniProt	complete
involved_in	GO:0060030	dorsal convergence	PMID:9007234^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-116	P	Seeded From UniProt	complete
involved_in	GO:0060030	dorsal convergence	PMID:9007234^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-120224-9	P	Seeded From UniProt	complete
involved_in	GO:0060030	dorsal convergence	PMID:9007234^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-120224-10	P	Seeded From UniProt	complete
involved_in	GO:0060028	convergent extension involved in axis elongation	PMID:9007236^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1083	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:25183869^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:23821037^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-131003-4 ZFIN:ZDB-MRPHLNO-131003-5	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:21262816^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5 ZFIN:ZDB-MRPHLNO-110222-3	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:18971206^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5 ZFIN:ZDB-MRPHLNO-090312-2	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:18971206^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2 ZFIN:ZDB-MRPHLNO-090312-2	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:18582857^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5 ZFIN:ZDB-MRPHLNO-081212-1	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:17239849^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-011119-1 ZFIN:ZDB-GENO-070906-2	P	Seeded From UniProt	complete
involved_in	GO:0060026	convergent extension	PMID:20643117^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080918-2	P	Seeded From UniProt	complete
involved_in	GO:0060026	convergent extension	PMID:20643117^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
involved_in	GO:0060026	convergent extension	PMID:20643117^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
involved_in	GO:0060026	convergent extension	PMID:20043994^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5	P	Seeded From UniProt	complete
involved_in	GO:0060026	convergent extension	PMID:18195109^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080416-1	P	Seeded From UniProt	complete
involved_in	GO:0060026	convergent extension	PMID:12105418^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5	P	Seeded From UniProt	complete
involved_in	GO:0060026	convergent extension	PMID:12105418^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055002	striated muscle cell development	PMID:17849437^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070906-2	P	Seeded From UniProt	complete
involved_in	GO:0055002	striated muscle cell development	PMID:17849437^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
involved_in	GO:0048840	otolith development	PMID:20643117^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2 ZFIN:ZDB-MRPHLNO-080918-2	P	Seeded From UniProt	complete
involved_in	GO:0048840	otolith development	PMID:20643117^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
involved_in	GO:0048570	notochord morphogenesis	PMID:9007234^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-263	P	Seeded From UniProt	complete
involved_in	GO:0048570	notochord morphogenesis	PMID:9007234^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-116	P	Seeded From UniProt	complete
involved_in	GO:0048570	notochord morphogenesis	PMID:9007234^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-120224-9	P	Seeded From UniProt	complete
involved_in	GO:0048570	notochord morphogenesis	PMID:9007234^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-120224-10	P	Seeded From UniProt	complete
involved_in	GO:0048048	embryonic eye morphogenesis	PMID:9142986^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1037	P	Seeded From UniProt	complete
involved_in	GO:0044782	cilium organization	PMID:20305649^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:12874125^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-263 ZFIN:ZDB-MRPHLNO-060209-7	P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:15882862^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050823-4	P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:15882862^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050823-1	P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:12105418^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:11780127^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0036342	post-anal tail morphogenesis	PMID:18045497^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5	P	Seeded From UniProt	complete
involved_in	GO:0036342	post-anal tail morphogenesis	PMID:18045497^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-080422-2	P	Seeded From UniProt	complete
involved_in	GO:0036342	post-anal tail morphogenesis	PMID:18045497^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070308-4 ZFIN:ZDB-MRPHLNO-041217-5	P	Seeded From UniProt	complete
involved_in	GO:0036342	post-anal tail morphogenesis	PMID:18045497^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5	P	Seeded From UniProt	complete
involved_in	GO:0035845	photoreceptor cell outer segment organization	PMID:27571019^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-021217-3	P	Seeded From UniProt	complete
involved_in	GO:0035844	cloaca development	PMID:23213452^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110614-5	P	Seeded From UniProt	complete
involved_in	GO:0033564	anterior/posterior axon guidance	PMID:27955617^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	PMID:24021482^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-131216-9	P	Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	PMID:12105418^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0021535	cell migration in hindbrain	PMID:17392791^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
involved_in	GO:0014812	muscle cell migration	PMID:17849437^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070906-2	P	Seeded From UniProt	complete
involved_in	GO:0014812	muscle cell migration	PMID:17849437^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:20643117^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2 ZFIN:ZDB-MRPHLNO-080918-2	P	Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:20643117^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21262816^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0003401	axis elongation	PMID:21498478^[32]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5 ZFIN:ZDB-MRPHLNO-110808-1	P	Seeded From UniProt	complete
involved_in	GO:0003401	axis elongation	PMID:21498478^[32]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070305-2 ZFIN:ZDB-MRPHLNO-110808-1	P	Seeded From UniProt	complete
involved_in	GO:0001841	neural tube formation	PMID:16407953^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1083	P	Seeded From UniProt	complete
involved_in	GO:0001839	neural plate morphogenesis	PMID:16502420^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5	P	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:19013446^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5 ZFIN:ZDB-MRPHLNO-060119-1	P	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:19013446^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5 ZFIN:ZDB-MRPHLNO-051128-5	P	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:19013446^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5	P	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:12105418^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:12105418^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5	P	Seeded From UniProt	complete
involved_in	GO:0001736	establishment of planar polarity	PMID:21602787^[35]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5 ZFIN:ZDB-MRPHLNO-120402-3	P	Seeded From UniProt	complete
involved_in	GO:0001736	establishment of planar polarity	PMID:21602787^[35]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5 ZFIN:ZDB-MRPHLNO-080929-3	P	Seeded From UniProt	complete
involved_in	GO:0001736	establishment of planar polarity	PMID:21602787^[35]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5 ZFIN:ZDB-MRPHLNO-080107-2	P	Seeded From UniProt	complete
involved_in	GO:0001736	establishment of planar polarity	PMID:21693519^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5	P	Seeded From UniProt	complete
involved_in	GO:0001736	establishment of planar polarity	PMID:12105418^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:12105418^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:23213452^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110614-5 ZFIN:ZDB-MRPHLNO-130117-3	P	Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:23213452^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110614-5	P	Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:15254551^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009539	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009539	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0306	P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Jessen, JR et al. (2002) Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Nat. Cell Biol. 4 610-5 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Park, M & Moon, RT (2002) The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat. Cell Biol. 4 20-5 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Carreira-Barbosa, F et al. (2003) Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development 130 4037-46 PubMed GONUTS page
↑ ^4.0 ^4.1 Marlow, F et al. (1998) Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish. Dev. Biol. 203 382-99 PubMed GONUTS page
↑ Solnica-Krezel, L et al. (1996) Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development 123 67-80 PubMed GONUTS page
↑ ^6.0 ^6.1 Hammerschmidt, M et al. (1996) Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development 123 143-51 PubMed GONUTS page
↑ Sepich, DS et al. (2000) Role of the zebrafish trilobite locus in gastrulation movements of convergence and extension. Genesis 27 159-73 PubMed GONUTS page
↑ ^8.0 ^8.1 Yin, C & Solnica-Krezel, L (2007) Convergence and extension movements mediate the specification and fate maintenance of zebrafish slow muscle precursors. Dev. Biol. 304 141-55 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 Stemple, DL et al. (1996) Mutations affecting development of the notochord in zebrafish. Development 123 117-28 PubMed GONUTS page
↑ ^10.0 ^10.1 Ciruna, B et al. (2006) Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature 439 220-4 PubMed GONUTS page
↑ Bingham, S et al. (2002) The Zebrafish trilobite gene is essential for tangential migration of branchiomotor neurons. Dev. Biol. 242 149-60 PubMed GONUTS page
↑ Henry, CA et al. (2000) Somites in zebrafish doubly mutant for knypek and trilobite form without internal mesenchymal cells or compaction. Curr. Biol. 10 1063-6 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Li, X et al. (2013) Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development 140 3028-39 PubMed GONUTS page
↑ Sittaramane, V et al. (2013) The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function. Dev. Biol. 382 400-12 PubMed GONUTS page
↑ ^15.0 ^15.1 Sun, SD et al. (2016) Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance. BMC Neurosci 17 83 PubMed GONUTS page
↑ ^16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 May-Simera, HL et al. (2010) Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish. Dev. Biol. 345 215-25 PubMed GONUTS page
↑ ^17.0 ^17.1 Borovina, A et al. (2010) Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia. Nat. Cell Biol. 12 407-12 PubMed GONUTS page
↑ ^18.0 ^18.1 Song, P et al. (2016) Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish. Invest. Ophthalmol. Vis. Sci. 57 4517-26 PubMed GONUTS page
↑ Young, T et al. (2014) The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Development 141 3505-16 PubMed GONUTS page
↑ ^20.0 ^20.1 Li, S et al. (2011) Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity. Proc. Natl. Acad. Sci. U.S.A. 108 2264-9 PubMed GONUTS page
↑ ^21.0 ^21.1 Ferrante, MI et al. (2009) Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Hum. Mol. Genet. 18 289-303 PubMed GONUTS page
↑ Vervenne, HB et al. (2008) Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. Dev. Biol. 320 267-77 PubMed GONUTS page
↑ Reynolds, A et al. () VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish. Mech. Dev. 127 385-92 PubMed GONUTS page
↑ Yin, C et al. (2008) Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulation. J. Cell Biol. 180 221-32 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Yin, C & Solnica-Krezel, L (2007) Convergence and extension movements affect dynamic notochord-somite interactions essential for zebrafish slow muscle morphogenesis. Dev. Dyn. 236 2742-56 PubMed GONUTS page
↑ Heisenberg, CP & Nüsslein-Volhard, C (1997) The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. Dev. Biol. 184 85-94 PubMed GONUTS page
↑ ^27.0 ^27.1 Formstone, CJ & Mason, I (2005) Combinatorial activity of Flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway. Dev. Biol. 282 320-35 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Harrington, MJ et al. (2007) Cadherin-mediated adhesion regulates posterior body formation. BMC Dev. Biol. 7 130 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Bubenshchikova, E et al. (2012) Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis. Biol Open 1 588-96 PubMed GONUTS page
↑ Dohn, MR et al. (2013) Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation. Dev. Biol. 383 39-51 PubMed GONUTS page
↑ Tawk, M et al. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature 446 797-800 PubMed GONUTS page
↑ ^32.0 ^32.1 Burcklé, C et al. (2011) Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros. Hum. Mol. Genet. 20 2611-27 PubMed GONUTS page
↑ Takamiya, M & Campos-Ortega, JA (2006) Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis. Dev. Dyn. 235 978-97 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Sittaramane, V et al. (2009) The cell adhesion molecule Tag1, transmembrane protein Stbm/Vangl2, and Lamininalpha1 exhibit genetic interactions during migration of facial branchiomotor neurons in zebrafish. Dev. Biol. 325 363-73 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 Zhao, C & Malicki, J (2011) Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J. 30 2532-44 PubMed GONUTS page
↑ Walsh, GS et al. (2011) Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration. Development 138 3033-42 PubMed GONUTS page
↑ Gong, Y et al. (2004) Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature 430 689-93 PubMed GONUTS page

[PMID:12105418-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Jessen, JR et al. (2002) Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Nat. Cell Biol. 4 610-5 PubMed GONUTS page

[PMID:11780127-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Park, M & Moon, RT (2002) The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat. Cell Biol. 4 20-5 PubMed GONUTS page

[PMID:12874125-3] 3.0 ^3.1 ^3.2 Carreira-Barbosa, F et al. (2003) Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development 130 4037-46 PubMed GONUTS page

[PMID:9808788-4] 4.0 ^4.1 Marlow, F et al. (1998) Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish. Dev. Biol. 203 382-99 PubMed GONUTS page

[PMID:9007230-5] Solnica-Krezel, L et al. (1996) Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development 123 67-80 PubMed GONUTS page

[PMID:9007236-6] 6.0 ^6.1 Hammerschmidt, M et al. (1996) Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development 123 143-51 PubMed GONUTS page

[PMID:10992326-7] Sepich, DS et al. (2000) Role of the zebrafish trilobite locus in gastrulation movements of convergence and extension. Genesis 27 159-73 PubMed GONUTS page

[PMID:17239849-8] 8.0 ^8.1 Yin, C & Solnica-Krezel, L (2007) Convergence and extension movements mediate the specification and fate maintenance of zebrafish slow muscle precursors. Dev. Biol. 304 141-55 PubMed GONUTS page

[PMID:9007234-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 Stemple, DL et al. (1996) Mutations affecting development of the notochord in zebrafish. Development 123 117-28 PubMed GONUTS page

[PMID:16407953-10] 10.0 ^10.1 Ciruna, B et al. (2006) Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature 439 220-4 PubMed GONUTS page

[PMID:11820812-11] Bingham, S et al. (2002) The Zebrafish trilobite gene is essential for tangential migration of branchiomotor neurons. Dev. Biol. 242 149-60 PubMed GONUTS page

[PMID:10996075-12] Henry, CA et al. (2000) Somites in zebrafish doubly mutant for knypek and trilobite form without internal mesenchymal cells or compaction. Curr. Biol. 10 1063-6 PubMed GONUTS page

[PMID:23821037-13] 13.0 ^13.1 ^13.2 Li, X et al. (2013) Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development 140 3028-39 PubMed GONUTS page

[PMID:23988578-14] Sittaramane, V et al. (2013) The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function. Dev. Biol. 382 400-12 PubMed GONUTS page

[PMID:27955617-15] 15.0 ^15.1 Sun, SD et al. (2016) Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance. BMC Neurosci 17 83 PubMed GONUTS page

[PMID:20643117-16] 16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 May-Simera, HL et al. (2010) Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish. Dev. Biol. 345 215-25 PubMed GONUTS page

[PMID:20305649-17] 17.0 ^17.1 Borovina, A et al. (2010) Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia. Nat. Cell Biol. 12 407-12 PubMed GONUTS page

[PMID:27571019-18] 18.0 ^18.1 Song, P et al. (2016) Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish. Invest. Ophthalmol. Vis. Sci. 57 4517-26 PubMed GONUTS page

[PMID:25183869-19] Young, T et al. (2014) The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Development 141 3505-16 PubMed GONUTS page

[PMID:21262816-20] 20.0 ^20.1 Li, S et al. (2011) Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity. Proc. Natl. Acad. Sci. U.S.A. 108 2264-9 PubMed GONUTS page

[PMID:18971206-21] 21.0 ^21.1 Ferrante, MI et al. (2009) Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Hum. Mol. Genet. 18 289-303 PubMed GONUTS page

[PMID:18582857-22] Vervenne, HB et al. (2008) Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. Dev. Biol. 320 267-77 PubMed GONUTS page

[PMID:20043994-23] Reynolds, A et al. () VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish. Mech. Dev. 127 385-92 PubMed GONUTS page

[PMID:18195109-24] Yin, C et al. (2008) Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulation. J. Cell Biol. 180 221-32 PubMed GONUTS page

[PMID:17849437-25] 25.0 ^25.1 ^25.2 ^25.3 Yin, C & Solnica-Krezel, L (2007) Convergence and extension movements affect dynamic notochord-somite interactions essential for zebrafish slow muscle morphogenesis. Dev. Dyn. 236 2742-56 PubMed GONUTS page

[PMID:9142986-26] Heisenberg, CP & Nüsslein-Volhard, C (1997) The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. Dev. Biol. 184 85-94 PubMed GONUTS page

[PMID:15882862-27] 27.0 ^27.1 Formstone, CJ & Mason, I (2005) Combinatorial activity of Flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway. Dev. Biol. 282 320-35 PubMed GONUTS page

[PMID:18045497-28] 28.0 ^28.1 ^28.2 ^28.3 Harrington, MJ et al. (2007) Cadherin-mediated adhesion regulates posterior body formation. BMC Dev. Biol. 7 130 PubMed GONUTS page

[PMID:23213452-29] 29.0 ^29.1 ^29.2 Bubenshchikova, E et al. (2012) Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis. Biol Open 1 588-96 PubMed GONUTS page

[PMID:24021482-30] Dohn, MR et al. (2013) Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation. Dev. Biol. 383 39-51 PubMed GONUTS page

[PMID:17392791-31] Tawk, M et al. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature 446 797-800 PubMed GONUTS page

[PMID:21498478-32] 32.0 ^32.1 Burcklé, C et al. (2011) Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros. Hum. Mol. Genet. 20 2611-27 PubMed GONUTS page

[PMID:16502420-33] Takamiya, M & Campos-Ortega, JA (2006) Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis. Dev. Dyn. 235 978-97 PubMed GONUTS page

[PMID:19013446-34] 34.0 ^34.1 ^34.2 Sittaramane, V et al. (2009) The cell adhesion molecule Tag1, transmembrane protein Stbm/Vangl2, and Lamininalpha1 exhibit genetic interactions during migration of facial branchiomotor neurons in zebrafish. Dev. Biol. 325 363-73 PubMed GONUTS page

[PMID:21602787-35] 35.0 ^35.1 ^35.2 Zhao, C & Malicki, J (2011) Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J. 30 2532-44 PubMed GONUTS page

[PMID:21693519-36] Walsh, GS et al. (2011) Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration. Development 138 3033-42 PubMed GONUTS page

[PMID:15254551-37] Gong, Y et al. (2004) Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature 430 689-93 PubMed GONUTS page

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