PMID:11820812

Citation	Bingham, S, Higashijima, S, Okamoto, H and Chandrasekhar, A (2002) The Zebrafish trilobite gene is essential for tangential migration of branchiomotor neurons. Dev. Biol. 242:149-60
Abstract	Newborn neurons migrate extensively in the radial and tangential directions to organize the developing vertebrate nervous system. We show here that mutations in zebrafish trilobite (tri) that affect gastrulation-associated cell movements also eliminate tangential migration of motor neurons in the hindbrain. In the wild-type hindbrain, facial (nVII) and glossopharyngeal (nIX) motor neurons are induced in rhombomeres 4 and 6, respectively, and migrate tangentially into r6 and r7 (nVII) and r7 (nIX). In all three tri alleles examined, although normal numbers of motor neurons are induced, nVII motor neurons are found exclusively in r4, and nIX-like motor neurons are found exclusively in r6. The migration of other neuronal and nonneuronal cell types is unaffected in tri mutants. Rhombomere formation and the development of other hindbrain neurons are also unaffected in tri mutants. Furthermore, tangential neuronal migration occurs normally in the gastrulation mutant knypek, indicating that the trilobite neuron phenotype does not arise nonspecifically from aberrant gastrulation-associated movements. We conclude that trilobite function is specifically required for two types of cell migration that occur at different stages of zebrafish development.
Links	PubMed PMC3011822 Online version:10.1006/dbio.2001.0532
Keywords	Animals; Branchial Region/cytology; Cell Movement/genetics; Green Fluorescent Proteins; Immunohistochemistry; Luminescent Proteins/genetics; Motor Neurons/cytology; Mutation; Rhombencephalon/cytology; Zebrafish/genetics
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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