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DANRE:TBX2

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) tbx2b (synonyms: tbx-c)
Protein Name(s) T-box transcription factor TBX2b

T-box protein 2b

External Links
UniProt Q7ZTU9
EMBL AF179405
BC051603
AF136946
RefSeq NP_571126.1
UniGene Dr.8233
Ensembl ENSDART00000122101
GeneID 30253
KEGG dre:30253
CTD 30253
ZFIN ZDB-GENE-990726-27
eggNOG NOG240293
GeneTree ENSGT00760000118897
HOGENOM HOG000038046
HOVERGEN HBG000412
InParanoid Q7ZTU9
KO K10176
OMA SPAPEHH
OrthoDB EOG7W9RV1
PhylomeDB Q7ZTU9
TreeFam TF106341
NextBio 20806703
PRO PR:Q7ZTU9
Proteomes UP000000437
Bgee Q7ZTU9
ExpressionAtlas Q7ZTU9
GO GO:0005634
GO:0003677
GO:0003700
GO:0048318
GO:0007420
GO:0060219
GO:0003205
GO:0007155
GO:0042074
GO:0008283
GO:0035050
GO:0021538
GO:0001947
GO:0048663
GO:0030903
GO:0043704
GO:0008016
GO:0046549
GO:0046548
GO:0006351
Gene3D 2.60.40.820
InterPro IPR008967
IPR022582
IPR002070
IPR001699
IPR018186
PANTHER PTHR11267
Pfam PF00907
PF12598
PRINTS PR00938
PR00937
SMART SM00425
SUPFAM SSF49417
PROSITE PS01283
PS01264
PS50252

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001947

heart looping

PMID:18347092[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080714-2

P

Seeded From UniProt

complete

GO:0003205

cardiac chamber development

PMID:21448936[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-110718-2

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001699
InterPro:IPR002070
InterPro:IPR008967
InterPro:IPR018186

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001699
InterPro:IPR002070
InterPro:IPR018186

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001699
InterPro:IPR002070
InterPro:IPR008967
InterPro:IPR018186

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

PMID:16033799[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051003-3

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:16033799[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051003-3

P

Seeded From UniProt

complete

GO:0008016

regulation of heart contraction

PMID:18347092[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080714-2

P

Seeded From UniProt

complete

GO:0008283

cell proliferation

PMID:16033799[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051003-3

P

Seeded From UniProt

complete

GO:0021538

epithalamus development

PMID:18385257[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080814-12

P

Seeded From UniProt

complete

GO:0021538

epithalamus development

PMID:18385257[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050928-1

P

Seeded From UniProt

complete

GO:0021538

epithalamus development

PMID:18385257[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051012-1

P

Seeded From UniProt

complete

GO:0021538

epithalamus development

PMID:18629869[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-081208-1

P

Seeded From UniProt

complete

GO:0030903

notochord development

PMID:16033799[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051003-3

P

Seeded From UniProt

complete

GO:0035050

embryonic heart tube development

PMID:18347092[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080714-2

P

Seeded From UniProt

complete

GO:0042074

cell migration involved in gastrulation

PMID:16033799[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051003-3

P

Seeded From UniProt

complete

GO:0042461

photoreceptor cell development

PMID:24465536[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-130130-6

P

Seeded From UniProt

complete

GO:0043704

photoreceptor cell fate specification

PMID:19179291[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080920-2

P

Seeded From UniProt

complete

GO:0046548

retinal rod cell development

PMID:15755805[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050928-1

P

Seeded From UniProt

complete

GO:0046548

retinal rod cell development

PMID:15755805[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051012-1

P

Seeded From UniProt

complete

GO:0046549

retinal cone cell development

PMID:15755805[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050928-1

P

Seeded From UniProt

complete

GO:0046549

retinal cone cell development

PMID:15755805[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051012-1

P

Seeded From UniProt

complete

GO:0048318

axial mesoderm development

PMID:10331981[9]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048663

neuron fate commitment

PMID:16033799[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051003-3

P

Seeded From UniProt

complete

GO:0060219

camera-type eye photoreceptor cell differentiation

PMID:24681822[10]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980526-373

P

Seeded From UniProt

complete

GO:0060219

camera-type eye photoreceptor cell differentiation

PMID:24681822[10]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080920-2

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Chi, NC et al. (2008) Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev. 22 734-9 PubMed GONUTS page
  2. Sedletcaia, A & Evans, T (2011) Heart chamber size in zebrafish is regulated redundantly by duplicated tbx2 genes. Dev. Dyn. 240 1548-57 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Fong, SH et al. (2005) Wnt signalling mediated by Tbx2b regulates cell migration during formation of the neural plate. Development 132 3587-96 PubMed GONUTS page
  4. 4.0 4.1 4.2 Snelson, CD et al. (2008) Tbx2b is required for the development of the parapineal organ. Development 135 1693-702 PubMed GONUTS page
  5. Snelson, CD et al. (2008) Formation of the asymmetric pineal complex in zebrafish requires two independently acting transcription factors. Dev. Dyn. 237 3538-44 PubMed GONUTS page
  6. Raymond, PA et al. (2014) Patterning the cone mosaic array in zebrafish retina requires specification of ultraviolet-sensitive cones. PLoS ONE 9 e85325 PubMed GONUTS page
  7. Alvarez-Delfin, K et al. (2009) Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proc. Natl. Acad. Sci. U.S.A. 106 2023-8 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Gross, JM & Dowling, JE (2005) Tbx2b is essential for neuronal differentiation along the dorsal/ventral axis of the zebrafish retina. Proc. Natl. Acad. Sci. U.S.A. 102 4371-6 PubMed GONUTS page
  9. Dheen, T et al. (1999) Zebrafish tbx-c functions during formation of midline structures. Development 126 2703-13 PubMed GONUTS page
  10. 10.0 10.1 Duval, MG et al. (2014) gdf6a is required for cone photoreceptor subtype differentiation and for the actions of tbx2b in determining rod versus cone photoreceptor fate. PLoS ONE 9 e92991 PubMed GONUTS page