DANRE:TBX2

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	tbx2b (synonyms: tbx-c)
Protein Name(s)	T-box transcription factor TBX2b T-box protein 2b
External Links
UniProt	Q7ZTU9
EMBL	AF179405 BC051603 AF136946
RefSeq	NP_571126.1
UniGene	Dr.8233
Ensembl	ENSDART00000122101
GeneID	30253
KEGG	dre:30253
CTD	30253
ZFIN	ZDB-GENE-990726-27
eggNOG	NOG240293
GeneTree	ENSGT00760000118897
HOGENOM	HOG000038046
HOVERGEN	HBG000412
InParanoid	Q7ZTU9
KO	K10176
OMA	SPAPEHH
OrthoDB	EOG7W9RV1
PhylomeDB	Q7ZTU9
TreeFam	TF106341
NextBio	20806703
PRO	PR:Q7ZTU9
Proteomes	UP000000437
Bgee	Q7ZTU9
ExpressionAtlas	Q7ZTU9
GO	GO:0005634 GO:0003677 GO:0003700 GO:0048318 GO:0007420 GO:0060219 GO:0003205 GO:0007155 GO:0042074 GO:0008283 GO:0035050 GO:0021538 GO:0001947 GO:0048663 GO:0030903 GO:0043704 GO:0008016 GO:0046549 GO:0046548 GO:0006351
Gene3D	2.60.40.820
InterPro	IPR008967 IPR022582 IPR002070 IPR001699 IPR018186
PANTHER	PTHR11267
Pfam	PF00907 PF12598
PRINTS	PR00938 PR00937
SMART	SM00425
SUPFAM	SSF49417
PROSITE	PS01283 PS01264 PS50252

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0072068	late distal convoluted tubule development	PMID:27840199^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051012-1	P	Seeded From UniProt	complete
involved_in	GO:0072019	proximal convoluted tubule development	PMID:27840199^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051012-1	P	Seeded From UniProt	complete
involved_in	GO:0060219	camera-type eye photoreceptor cell differentiation	PMID:24681822^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980526-373	P	Seeded From UniProt	complete
involved_in	GO:0060219	camera-type eye photoreceptor cell differentiation	PMID:24681822^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080920-2	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:27840199^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051012-1	P	Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	PMID:16033799^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051003-3	P	Seeded From UniProt	complete
involved_in	GO:0048318	axial mesoderm development	PMID:10331981^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046551	retinal cone cell fate commitment	PMID:26936243^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-160104-4	P	Seeded From UniProt	complete
involved_in	GO:0046549	retinal cone cell development	PMID:15755805^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051012-1	P	Seeded From UniProt	complete
involved_in	GO:0046549	retinal cone cell development	PMID:15755805^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050928-1	P	Seeded From UniProt	complete
involved_in	GO:0046548	retinal rod cell development	PMID:15755805^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051012-1	P	Seeded From UniProt	complete
involved_in	GO:0046548	retinal rod cell development	PMID:15755805^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050928-1	P	Seeded From UniProt	complete
involved_in	GO:0043704	photoreceptor cell fate specification	PMID:19179291^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080920-2	P	Seeded From UniProt	complete
involved_in	GO:0042461	photoreceptor cell development	PMID:24465536^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-130130-6	P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:16033799^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051003-3	P	Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	PMID:27343557^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-161014-2	P	Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	PMID:18347092^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080714-2	P	Seeded From UniProt	complete
involved_in	GO:0030903	notochord development	PMID:16033799^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051003-3	P	Seeded From UniProt	complete
involved_in	GO:0021982	pineal gland development	PMID:27317804^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-161014-12 ZFIN:ZDB-MRPHLNO-051012-1	P	Seeded From UniProt	complete
involved_in	GO:0021982	pineal gland development	PMID:27317804^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051012-1	P	Seeded From UniProt	complete
involved_in	GO:0021538	epithalamus development	PMID:18629869^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-081208-1	P	Seeded From UniProt	complete
involved_in	GO:0021538	epithalamus development	PMID:18385257^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051012-1	P	Seeded From UniProt	complete
involved_in	GO:0021538	epithalamus development	PMID:18385257^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050928-1	P	Seeded From UniProt	complete
involved_in	GO:0021538	epithalamus development	PMID:18385257^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080814-12	P	Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	PMID:18347092^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080714-2	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:16033799^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051003-3	P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:16033799^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051003-3	P	Seeded From UniProt	complete
involved_in	GO:0003205	cardiac chamber development	PMID:21448936^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110718-2	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:18347092^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080714-2	P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001699 InterPro:IPR002070 InterPro:IPR008967 InterPro:IPR018186 InterPro:IPR036960	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001699 InterPro:IPR002070 InterPro:IPR018186 InterPro:IPR036960	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001699 InterPro:IPR002070 InterPro:IPR008967 InterPro:IPR018186 InterPro:IPR036960	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Drummond, BE et al. (2017) The tbx2a/b transcription factors direct pronephros segmentation and corpuscle of Stannius formation in zebrafish. Dev. Biol. 421 52-66 PubMed GONUTS page
↑ ^2.0 ^2.1 Duval, MG et al. (2014) gdf6a is required for cone photoreceptor subtype differentiation and for the actions of tbx2b in determining rod versus cone photoreceptor fate. PLoS ONE 9 e92991 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Fong, SH et al. (2005) Wnt signalling mediated by Tbx2b regulates cell migration during formation of the neural plate. Development 132 3587-96 PubMed GONUTS page
↑ Dheen, T et al. (1999) Zebrafish tbx-c functions during formation of midline structures. Development 126 2703-13 PubMed GONUTS page
↑ Novales Flamarique, I (2016) Diminished foraging performance of a mutant zebrafish with reduced population of ultraviolet cones. Proc. Biol. Sci. 283 20160058 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gross, JM & Dowling, JE (2005) Tbx2b is essential for neuronal differentiation along the dorsal/ventral axis of the zebrafish retina. Proc. Natl. Acad. Sci. U.S.A. 102 4371-6 PubMed GONUTS page
↑ Alvarez-Delfin, K et al. (2009) Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proc. Natl. Acad. Sci. U.S.A. 106 2023-8 PubMed GONUTS page
↑ Raymond, PA et al. (2014) Patterning the cone mosaic array in zebrafish retina requires specification of ultraviolet-sensitive cones. PLoS ONE 9 e85325 PubMed GONUTS page
↑ Just, S et al. (2016) The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation. Biochem. Biophys. Res. Commun. 477 581-588 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Chi, NC et al. (2008) Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev. 22 734-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Khuansuwan, S et al. (2016) A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex. Development 143 2641-50 PubMed GONUTS page
↑ Snelson, CD et al. (2008) Formation of the asymmetric pineal complex in zebrafish requires two independently acting transcription factors. Dev. Dyn. 237 3538-44 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Snelson, CD et al. (2008) Tbx2b is required for the development of the parapineal organ. Development 135 1693-702 PubMed GONUTS page
↑ Sedletcaia, A & Evans, T (2011) Heart chamber size in zebrafish is regulated redundantly by duplicated tbx2 genes. Dev. Dyn. 240 1548-57 PubMed GONUTS page

[PMID:27840199-1] 1.0 ^1.1 ^1.2 Drummond, BE et al. (2017) The tbx2a/b transcription factors direct pronephros segmentation and corpuscle of Stannius formation in zebrafish. Dev. Biol. 421 52-66 PubMed GONUTS page

[PMID:24681822-2] 2.0 ^2.1 Duval, MG et al. (2014) gdf6a is required for cone photoreceptor subtype differentiation and for the actions of tbx2b in determining rod versus cone photoreceptor fate. PLoS ONE 9 e92991 PubMed GONUTS page

[PMID:16033799-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Fong, SH et al. (2005) Wnt signalling mediated by Tbx2b regulates cell migration during formation of the neural plate. Development 132 3587-96 PubMed GONUTS page

[PMID:10331981-4] Dheen, T et al. (1999) Zebrafish tbx-c functions during formation of midline structures. Development 126 2703-13 PubMed GONUTS page

[PMID:26936243-5] Novales Flamarique, I (2016) Diminished foraging performance of a mutant zebrafish with reduced population of ultraviolet cones. Proc. Biol. Sci. 283 20160058 PubMed GONUTS page

[PMID:15755805-6] 6.0 ^6.1 ^6.2 ^6.3 Gross, JM & Dowling, JE (2005) Tbx2b is essential for neuronal differentiation along the dorsal/ventral axis of the zebrafish retina. Proc. Natl. Acad. Sci. U.S.A. 102 4371-6 PubMed GONUTS page

[PMID:19179291-7] Alvarez-Delfin, K et al. (2009) Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proc. Natl. Acad. Sci. U.S.A. 106 2023-8 PubMed GONUTS page

[PMID:24465536-8] Raymond, PA et al. (2014) Patterning the cone mosaic array in zebrafish retina requires specification of ultraviolet-sensitive cones. PLoS ONE 9 e85325 PubMed GONUTS page

[PMID:27343557-9] Just, S et al. (2016) The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation. Biochem. Biophys. Res. Commun. 477 581-588 PubMed GONUTS page

[PMID:18347092-10] 10.0 ^10.1 ^10.2 Chi, NC et al. (2008) Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev. 22 734-9 PubMed GONUTS page

[PMID:27317804-11] 11.0 ^11.1 Khuansuwan, S et al. (2016) A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex. Development 143 2641-50 PubMed GONUTS page

[PMID:18629869-12] Snelson, CD et al. (2008) Formation of the asymmetric pineal complex in zebrafish requires two independently acting transcription factors. Dev. Dyn. 237 3538-44 PubMed GONUTS page

[PMID:18385257-13] 13.0 ^13.1 ^13.2 Snelson, CD et al. (2008) Tbx2b is required for the development of the parapineal organ. Development 135 1693-702 PubMed GONUTS page

[PMID:21448936-14] Sedletcaia, A & Evans, T (2011) Heart chamber size in zebrafish is regulated redundantly by duplicated tbx2 genes. Dev. Dyn. 240 1548-57 PubMed GONUTS page

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DANRE:TBX2

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