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DANRE:Q9IAT0

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) No Information Provided. (synonyms: zic2 (ECO:0000313 with EMBL:AAF73190.1))
Protein Name(s) Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000026131)

Zic family member 2 (Odd-paired homolog, Drosophila), a (ECO:0000313 with EMBL:AAH65635.1) Zinc finger cerebellum 2 protein (ECO:0000313 with EMBL:AAF73190.1)

External Links
UniProt Q9IAT0
EMBL BX469902
AF151535
BC065635
RefSeq NP_571633.1
UniGene Dr.76889
SMR Q9IAT0
STRING 7955.ENSDARP00000026131
Ensembl ENSDART00000010774
GeneID 58077
KEGG dre:58077
CTD 58077
ZFIN ZDB-GENE-000710-4
eggNOG COG5048
GeneTree ENSGT00760000118771
HOGENOM HOG000232057
HOVERGEN HBG007135
KO K06235
OMA DSAHMGA
OrthoDB EOG76472R
PhylomeDB Q9IAT0
TreeFam TF351425
NextBio 20892337
PRO PR:Q9IAT0
Proteomes UP000000437
GO GO:0046872
GO:0003676
GO:0021846
GO:0033278
GO:0021536
GO:0009953
GO:0060059
GO:0048703
GO:0030901
GO:0045892
GO:0014032
GO:0001841
GO:0042127
GO:0008589
Gene3D 3.30.160.60
InterPro IPR007087
IPR015880
IPR013087
Pfam PF00096
SMART SM00355
PROSITE PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0060059

embryonic retina morphogenesis in camera-type eye

PMID:17215296[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:23665173[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0048385

regulation of retinoic acid receptor signaling pathway

PMID:23937294[3]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3
ZFIN:ZDB-MRPHLNO-130809-1

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:19855021[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

PMID:17215296[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0033278

cell proliferation in midbrain

PMID:17215296[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0030902

hindbrain development

PMID:23937294[3]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3
ZFIN:ZDB-MRPHLNO-130809-1

P

Seeded From UniProt

complete

involved_in

GO:0030901

midbrain development

PMID:19470582[5]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3
ZFIN:ZDB-MRPHLNO-070523-1

P

Seeded From UniProt

complete

involved_in

GO:0030901

midbrain development

PMID:17215296[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0021846

cell proliferation in forebrain

PMID:18358464[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0021536

diencephalon development

PMID:18358464[6]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-080605-1
ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0021536

diencephalon development

PMID:18358464[6]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-070406-1
ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0021536

diencephalon development

PMID:18358464[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0014032

neural crest cell development

PMID:23665173[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0009953

dorsal/ventral pattern formation

PMID:18248235[7]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-060811-12

P

Seeded From UniProt

complete

involved_in

GO:0009953

dorsal/ventral pattern formation

PMID:18248235[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008589

regulation of smoothened signaling pathway

PMID:19855021[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3

P

Seeded From UniProt

complete

involved_in

GO:0001841

neural tube formation

PMID:19470582[5]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070522-3
ZFIN:ZDB-MRPHLNO-070523-1

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106679
PANTHER:PTN002715599

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106679
PANTHER:PTN002715599
ZFIN:ZDB-GENE-000710-4

P

Seeded From UniProt

complete

involved_in

GO:0007417

central nervous system development

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106679
MGI:MGI:106683
MGI:MGI:1929518
PANTHER:PTN002323202
UniProtKB:Q15915
UniProtKB:Q8JJC0
ZFIN:ZDB-GENE-000208-4
ZFIN:ZDB-GENE-000710-4
ZFIN:ZDB-GENE-001103-3
ZFIN:ZDB-GENE-030219-92
ZFIN:ZDB-GENE-040622-1
ZFIN:ZDB-GENE-040622-4
ZFIN:ZDB-GENE-061207-1

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003002
FB:FBgn0039039
MGI:MGI:106676
MGI:MGI:106679
MGI:MGI:106683
MGI:MGI:107201
MGI:MGI:1929518
MGI:MGI:1932535
PANTHER:PTN001803442
SGD:S000002553
SGD:S000003592
SGD:S000004121
UniProtKB:O95409
UniProtKB:Q15915
WB:WBGene00004335
WB:WBGene00006604
dictyBase:DDB_G0291342

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003002
PANTHER:PTN001803442
SGD:S000002553
SGD:S000003592

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003002
MGI:MGI:106676
MGI:MGI:106679
MGI:MGI:106683
MGI:MGI:107201
MGI:MGI:1929518
MGI:MGI:1932535
PANTHER:PTN001803442
SGD:S000003592
WB:WBGene00004335
WB:WBGene00006604

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Nyholm, MK et al. (2007) The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum. Development 134 735-46 PubMed GONUTS page
  2. ↑ 2.0 2.1 Teslaa, JJ et al. (2013) Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development. Dev. Biol. 380 73-86 PubMed GONUTS page
  3. ↑ 3.0 3.1 Drummond, DL et al. (2013) The role of Zic transcription factors in regulating hindbrain retinoic acid signaling. BMC Dev. Biol. 13 31 PubMed GONUTS page
  4. ↑ 4.0 4.1 Sanek, NA et al. (2009) Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression. Development 136 3791-800 PubMed GONUTS page
  5. ↑ 5.0 5.1 Nyholm, MK et al. (2009) A novel genetic mechanism regulates dorsolateral hinge-point formation during zebrafish cranial neurulation. J. Cell. Sci. 122 2137-48 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Sanek, NA & Grinblat, Y (2008) A novel role for zebrafish zic2a during forebrain development. Dev. Biol. 317 325-35 PubMed GONUTS page
  7. ↑ 7.0 7.1 Dodou, E et al. (2004) Ventralized zebrafish embryo rescue by overexpression of Zic2a. Zebrafish 1 239-56 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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