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DANRE:Q9I8G3

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) No Information Provided.
Protein Name(s) Endothelin 1 (ECO:0000313 with EMBL:AAF82311.1)
External Links
UniProt Q9I8G3
EMBL AF281858
BC162539
RefSeq NP_571594.1
UniGene Dr.4076
GeneID 58032
KEGG dre:58032
CTD 1906
ZFIN ZDB-GENE-000920-1
HOVERGEN HBG051442
KO K16366
PhylomeDB Q9I8G3
NextBio 20892299
GO GO:0005576
GO:0048899
GO:0048901
GO:0060349
GO:0051216
GO:0060351
GO:0060536
GO:0009953
GO:0048703
GO:0060325
GO:0014033
GO:0019229
InterPro IPR020475
IPR019764
IPR001928
Pfam PF00322
PRINTS PR00365
SMART SM00272
PROSITE PS00270

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0060536

cartilage morphogenesis

PMID:21073867[1]

ECO:0000315

P

The three characteristic phenotypes of the ventral cartilages in alcama morphants; shortening, change of orientation and fusion to dorsal cartilages, are typical of the edn1-class of mutants (Fig. 3 G)

complete
CACAO 2070

GO:0050714

positive regulation of protein secretion

PMID:21073867[1]

ECO:0000315

P

edn1 RNA injection results in more than 50% increase in Alcama protein in WT and edn1−/− mutants (Fig. 3G)

complete
CACAO 2071

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:21073867[1]

ECO:0000315

P

To test whether Edn1 stabilizes Alcama protein by interfering with its degradation by the proteasome, we treated edn1−/− larvae with the proteasome inhibitor MG132 and measured Alcama levels. Alcama levels in the pharyngeal pouches increased by more than 300% upon treatment with MG-132 (Fig. 3H)

complete
CACAO 2072

GO:0045597

positive regulation of cell differentiation

PMID:21073867[1]

ECO:0000315

P

edn1 over-expression……resulting in a 300% increase in the number of edn1−/− mutants with dlx5a staining (sum of strong and partial) (Fig. 5D).

complete
CACAO 2073

involved_in

GO:0045597

positive regulation of cell differentiation

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050714

positive regulation of protein secretion

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904888

cranial skeletal system development

PMID:27058748[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

involved_in

GO:0060536

cartilage morphogenesis

PMID:9007254[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

involved_in

GO:0060351

cartilage development involved in endochondral bone morphogenesis

PMID:20431122[4]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068
ZFIN:ZDB-MRPHLNO-041207-6

P

Seeded From UniProt

complete

involved_in

GO:0060351

cartilage development involved in endochondral bone morphogenesis

PMID:20431122[4]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-100727-7

P

Seeded From UniProt

complete

involved_in

GO:0060351

cartilage development involved in endochondral bone morphogenesis

PMID:20431122[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

involved_in

GO:0060349

bone morphogenesis

PMID:20171200[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060317-3

P

Seeded From UniProt

complete

involved_in

GO:0060325

face morphogenesis

PMID:20431122[4]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068
ZFIN:ZDB-MRPHLNO-041207-6

P

Seeded From UniProt

complete

involved_in

GO:0060325

face morphogenesis

PMID:20431122[4]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-100727-7

P

Seeded From UniProt

complete

involved_in

GO:0060325

face morphogenesis

PMID:20431122[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

PMID:16678149[6]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1065
ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

PMID:16759393[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060317-3

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

PMID:16678149[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060317-3

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

PMID:16678149[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

involved_in

GO:0048901

anterior lateral line neuromast development

PMID:20171200[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060317-3

P

Seeded From UniProt

complete

involved_in

GO:0048899

anterior lateral line development

PMID:20171200[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060317-3

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:24915580[8]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-030131-9854

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:17239364[9]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-070209-215
ZFIN:ZDB-GENO-080226-1

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:28109039[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060317-3

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:27880803[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060317-3

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:23826316[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-150219-10
ZFIN:ZDB-GENO-150219-12

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:12588851[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:10934026[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

involved_in

GO:0014033

neural crest cell differentiation

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

involved_in

GO:0009953

dorsal/ventral pattern formation

PMID:22031546[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-130816-8

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001928
InterPro:IPR019764

C

Seeded From UniProt

complete

involved_in

GO:0019229

regulation of vasoconstriction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001928
InterPro:IPR019764

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Choudhry, P et al. (2011) Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis. Dev. Biol. 349 483-93 PubMed GONUTS page
  2. ↑ Barske, L et al. (2016) Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLoS Genet. 12 e1005967 PubMed GONUTS page
  3. ↑ Piotrowski, T et al. (1996) Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation. Development 123 345-56 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Zuniga, E et al. (2010) Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face. Development 137 1843-52 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Wada, H et al. (2010) Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish. Dev. Biol. 340 583-94 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Walker, MB et al. (2006) Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning. Dev. Biol. 295 194-205 PubMed GONUTS page
  7. ↑ Nissen, RM et al. (2006) A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression. BMC Dev. Biol. 6 28 PubMed GONUTS page
  8. ↑ Dworkin, S et al. (2014) Grainyhead-like 3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton. Mech. Dev. 133 77-90 PubMed GONUTS page
  9. ↑ Walker, MB et al. (2007) phospholipase C, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish. Dev. Biol. 304 194-207 PubMed GONUTS page
  10. ↑ Iklé, JM et al. (2017) Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning. Genesis 55 PubMed GONUTS page
  11. ↑ Alvarado, E et al. (2016) Wdr68 Mediates Dorsal and Ventral Patterning Events for Craniofacial Development. PLoS ONE 11 e0166984 PubMed GONUTS page
  12. ↑ Sasaki, MM et al. (2013) edn1 and hand2 Interact in early regulation of pharyngeal arch outgrowth during zebrafish development. PLoS ONE 8 e67522 PubMed GONUTS page
  13. ↑ Miller, CT et al. (2003) Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development 130 1353-65 PubMed GONUTS page
  14. ↑ Miller, CT et al. (2000) sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development. Development 127 3815-28 PubMed GONUTS page
  15. ↑ Zuniga, E et al. (2011) Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development 138 5147-56 PubMed GONUTS page
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