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PMID:16759393
| Citation |
Nissen, RM, Amsterdam, A and Hopkins, N (2006) A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression. BMC Dev. Biol. 6:28 |
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| Abstract |
Craniofacial birth defects result from defects in cranial neural crest (NC) patterning and morphogenesis. The vertebrate craniofacial skeleton is derived from cranial NC cells and the patterning of these cells occurs within the pharyngeal arches. Substantial efforts have led to the identification of several genes required for craniofacial skeletal development such as the endothelin-1 (edn1) signaling pathway that is required for lower jaw formation. However, many essential genes required for craniofacial development remain to be identified. |
| Links |
PubMed PMC1523201 Online version:10.1186/1471-213X-6-28 |
| Keywords |
Animals; Body Patterning; Conserved Sequence; Craniofacial Abnormalities/genetics; Endothelin-1/genetics; Gene Expression; Mutation; Neural Crest; Nuclear Proteins/genetics; Nuclear Proteins/physiology; Zebrafish; Zebrafish Proteins/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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