DANRE:F5HSE3

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	nipblb
Protein Name(s)	Nipped-B like b
External Links
UniProt	F5HSE3
EMBL	AB630366
IPI	IPI01007497
RefSeq	NP_001233213.1
GeneID	570900
KEGG	dre:570900
CTD	570900
KO	K06672
NextBio	20890338
GO	GO:0005488
InterPro	IPR011989 IPR016024 IPR024986
Gene3D	G3DSA:1.25.10.10
Pfam	PF12830
SUPFAM	SSF48371

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071921	cohesin loading	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6KC79	P	Seeded From UniProt	complete
involved_in	GO:0071733	transcriptional activation by promoter-enhancer looping	PMID:25255084^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-111201-1 ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:0071733	transcriptional activation by promoter-enhancer looping	PMID:25255084^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080819-1 ZFIN:ZDB-MRPHLNO-111201-1 ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:0048703	embryonic viscerocranium morphogenesis	PMID:25378554^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-111201-1 ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	PMID:22039349^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-111201-1 ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:0035118	embryonic pectoral fin morphogenesis	PMID:25255084^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-111201-1 ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:0035118	embryonic pectoral fin morphogenesis	PMID:25255084^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080819-1 ZFIN:ZDB-MRPHLNO-111201-1 ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:0009303	rRNA transcription	PMID:25378554^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-111201-1 ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:22039349^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-111201-1 ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:22039349^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:0006412	translation	PMID:25378554^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-111201-1 ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:22039349^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-111201-3	P	Seeded From UniProt	complete
involved_in	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P	Seeded From UniProt	complete
involved_in	GO:1905406	positive regulation of mitotic cohesin loading	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 PomBase:SPAC31A2.05c	P	Seeded From UniProt	complete
part_of	GO:0090694	Scc2-Scc4 cohesin loading complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 PomBase:SPAC31A2.05c UniProtKB:Q6KC79	C	Seeded From UniProt	complete
involved_in	GO:0071733	transcriptional activation by promoter-enhancer looping	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 PANTHER:PTN000496017 ZFIN:ZDB-GENE-030131-6070 ZFIN:ZDB-GENE-060526-121	P	Seeded From UniProt	complete
involved_in	GO:0071169	establishment of protein localization to chromatin	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P	Seeded From UniProt	complete
involved_in	GO:0070550	rDNA condensation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P	Seeded From UniProt	complete
involved_in	GO:0048703	embryonic viscerocranium morphogenesis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496041 ZFIN:ZDB-GENE-060526-121	P	Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496041 ZFIN:ZDB-GENE-030131-6070 ZFIN:ZDB-GENE-060526-121	P	Seeded From UniProt	complete
involved_in	GO:0034087	establishment of mitotic sister chromatid cohesion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496041 ZFIN:ZDB-GENE-030131-6070 ZFIN:ZDB-GENE-060526-121	P	Seeded From UniProt	complete
involved_in	GO:0007076	mitotic chromosome condensation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P	Seeded From UniProt	complete
involved_in	GO:0007064	mitotic sister chromatid cohesion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 PANTHER:PTN000496017 UniProtKB:Q6KC79	P	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 MGI:MGI:1913976 PANTHER:PTN000496017 SGD:S000002588 UniProtKB:Q6KC79	C	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 MGI:MGI:1913976 PANTHER:PTN000496017	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	C	Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913976 PANTHER:PTN000496017	C	Seeded From UniProt	complete
part_of	GO:0000228	nuclear chromosome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 PomBase:SPAC31A2.05c	C	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033031	F	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033031	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Muto, A et al. (2014) Nipbl and mediator cooperatively regulate gene expression to control limb development. PLoS Genet. 10 e1004671 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Xu, B et al. (2015) L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome. Hum. Mol. Genet. 24 1540-55 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Muto, A et al. (2011) Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome. PLoS Biol. 9 e1001181 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25255084-1] 1.0 ^1.1 ^1.2 ^1.3 Muto, A et al. (2014) Nipbl and mediator cooperatively regulate gene expression to control limb development. PLoS Genet. 10 e1004671 PubMed GONUTS page

[PMID:25378554-2] 2.0 ^2.1 ^2.2 Xu, B et al. (2015) L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome. Hum. Mol. Genet. 24 1540-55 PubMed GONUTS page

[PMID:22039349-3] 3.0 ^3.1 ^3.2 ^3.3 Muto, A et al. (2011) Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome. PLoS Biol. 9 e1001181 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:F5HSE3

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