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DANRE:CELF1
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | celf1 (synonyms: brul, cugbp1) | |
| Protein Name(s) | CUGBP Elav-like family member 1
CELF-1 Bruno-like protein 2 CUG triplet repeat RNA-binding protein 1 CUG-BP1 CUG-BP- and ETR-3-like factor 1 EDEN-BP/Bruno-like protein RNA-binding protein BRUNOL-2 | |
| External Links | ||
| UniProt | Q9IBD0 | |
| EMBL | AB032726 BC049453 | |
| RefSeq | NP_571688.1 XP_005169052.1 | |
| UniGene | Dr.133224 Dr.75890 | |
| ProteinModelPortal | Q9IBD0 | |
| SMR | Q9IBD0 | |
| PRIDE | Q9IBD0 | |
| Ensembl | ENSDART00000018448 ENSDART00000041055 ENSDART00000134570 | |
| GeneID | 58137 | |
| KEGG | dre:58137 | |
| CTD | 10658 | |
| ZFIN | ZDB-GENE-000501-1 | |
| eggNOG | NOG251494 | |
| GeneTree | ENSGT00560000076837 | |
| HOGENOM | HOG000004754 | |
| HOVERGEN | HBG107646 | |
| InParanoid | Q9IBD0 | |
| KO | K13207 | |
| OrthoDB | EOG7DVDBR | |
| PhylomeDB | Q9IBD0 | |
| NextBio | 20892387 | |
| PRO | PR:Q9IBD0 | |
| Proteomes | UP000000437 | |
| Bgee | Q9IBD0 | |
| GO | GO:0005737 GO:0005634 GO:0000166 GO:0003723 GO:0006397 GO:0008380 | |
| Gene3D | 3.30.70.330 | |
| InterPro | IPR002343 IPR012677 IPR000504 | |
| Pfam | PF00076 | |
| PRINTS | PR00961 | |
| SMART | SM00360 | |
| PROSITE | PS50102 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0001889 |
liver development |
ECO:0000315 |
P |
Figure 2 A-F illustrates deficiencies in mutants to correctly form the liver. |
complete | |||||
| GO:0061113 |
pancreas morphogenesis |
ECO:0000315 |
P |
Figure 2 G-I illustrates deficiencies in pancreas morphogenesis. |
complete | |||||
| GO:0048588 |
developmental cell growth |
ECO:0000315 |
P |
Figure 3 shows a decrease in endodermal cell growth with KD mutants. |
complete | |||||
| GO:0016477 |
cell migration |
ECO:0000315 |
P |
Figure 4 |
complete | |||||
|
involved_in |
GO:0016477 |
cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048588 |
developmental cell growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061113 |
pancreas morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001889 |
liver development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990402 |
embryonic liver development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-121102-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070306 |
lens fiber cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-180827-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061031 |
endodermal digestive tract morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-121102-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061014 |
positive regulation of mRNA catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061014 |
positive regulation of mRNA catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-121102-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048565 |
digestive tract development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-121102-2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045495 |
pole plasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031016 |
pancreas development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-121102-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007368 |
determination of left/right symmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-121102-2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003730 |
mRNA 3'-UTR binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-990621-7 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-990621-7 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-980526-561 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-070319-1 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-031117-1 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1990904 |
ribonucleoprotein complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0265297 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006376 |
mRNA splice site selection |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1338822 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000114 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000114 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1932407 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000114 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000114 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Tahara, N et al. (2013) Celf1 is required for formation of endoderm-derived organs in zebrafish. Int J Mol Sci 14 18009-23 PubMed GONUTS page
- ↑ Siddam, AD et al. (2018) The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development. PLoS Genet. 14 e1007278 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Matsui, T et al. (2012) Celf1 regulation of dmrt2a is required for somite symmetry and left-right patterning during zebrafish development. Development 139 3553-60 PubMed GONUTS page
- ↑ 4.0 4.1 Hashimoto, Y et al. (2006) Bruno-like protein is localized to zebrafish germ plasm during the early cleavage stages. Gene Expr. Patterns 6 201-5 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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