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Category:Team Honey Badgers 14

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableHUMAN:SMUF2Cmpete, Team Honey Badgers 142014-03-02 12:39:46 CSTGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway (P)PMID:19255252ECO:0000314 direct assay evidence used in manual assertion

TGF-βR1 was significantly down-regulated in Smurf2 over-expressed cells, Figure 3.

challenge
updatedbyinstructorHUMAN:SMUF2Cmpete, Team Honey Badgers 142014-03-02 12:15:38 CSTGO:1901165 positive regulation of trophoblast cell migration (P)PMID:19255252ECO:0000314 direct assay evidence used in manual assertion

Over-expression of Smurf2 enhanced the migration and invasion of HTR-8/SVneo Cells, Figure 2.

challenge
updatedbyinstructorHUMAN:GDIR2Cmpete, Team Honey Badgers 142014-02-27 09:30:15 CSTGO:1901164 negative regulation of trophoblast cell migration (P)PMID:24554735ECO:0000314 direct assay evidence used in manual assertion

Over-expression of RhoGDI2

markedly inhibited the migration of HTR-8/SVneo cells. Knockdown of RhoGDI2 increased the migration of HTR-8/SVneo cells, Figure 5.

challenge
acceptableHUMAN:GDIR2Cmpete, Team Honey Badgers 142014-02-27 09:25:05 CSTGO:0003924 GTPase activity (F)PMID:24554735ECO:0000315 mutant phenotype evidence used in manual assertion

Knockdown of siRhoGDI2 in HTR-8/SVneo cells induced the activation of RAC1 as detected by

G-LISA, suggesting that RhoGDI2 inhibits RAC1. In contrast, RhoGDI2 overexpression inhibited the activation of RAC1, Figure 6.

challenge

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Pages in category "Team Honey Badgers 14"

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