HUMAN:GDIR2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ARHGDIB (synonyms: GDIA2, GDID4, RAP1GN1)
Protein Name(s)	Rho GDP-dissociation inhibitor 2 Rho GDI 2 Ly-GDI Rho-GDI beta
External Links
UniProt	P52566
EMBL	L20688 X69549 L07916 AF498927 AB451315 AB451445 CH471094 BC009200
CCDS	CCDS8671.1
PIR	A47742
RefSeq	NP_001166.3
UniGene	Hs.504877
PDB	1DS6
PDBsum	1DS6
ProteinModelPortal	P52566
SMR	P52566
BioGrid	106890
DIP	DIP-40959N
IntAct	P52566
MINT	MINT-1616342
STRING	9606.ENSP00000228945
PhosphoSite	P52566
OGP	P52566
SWISS-2DPAGE	P52566
MaxQB	P52566
PaxDb	P52566
PRIDE	P52566
DNASU	397
Ensembl	ENST00000228945 ENST00000541546 ENST00000541644
GeneID	397
KEGG	hsa:397
UCSC	uc001rcq.1
CTD	397
GeneCards	GC12M015094
H-InvDB	HIX0036989
HGNC	HGNC:679
HPA	CAB018584 HPA051235
MIM	602843
neXtProt	NX_P52566
PharmGKB	PA24964
eggNOG	NOG253438
GeneTree	ENSGT00390000006233
HOGENOM	HOG000175765
HOVERGEN	HBG000206
InParanoid	P52566
KO	K12462
OMA	VWKTAVK
OrthoDB	EOG72JWH9
PhylomeDB	P52566
TreeFam	TF105387
Reactome	REACT_11051
ChiTaRS	ARHGDIB
EvolutionaryTrace	P52566
GeneWiki	ARHGDIB
GenomeRNAi	397
NextBio	1665
PMAP-CutDB	P52566
PRO	PR:P52566
Proteomes	UP000005640
Bgee	P52566
CleanEx	HS_ARHGDIB
ExpressionAtlas	P52566
Genevestigator	P52566
GO	GO:0005737 GO:0016023 GO:0005856 GO:0005829 GO:0070062 GO:0005096 GO:0005094 GO:0030036 GO:0006928 GO:0006955 GO:0007275 GO:0007162 GO:0050790 GO:0051056 GO:0007266 GO:0007264
Gene3D	2.70.50.30
InterPro	IPR014756 IPR000406 IPR024792
PANTHER	PTHR10980
Pfam	PF02115
PRINTS	PR00492
SUPFAM	SSF81296

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0003924	GTPase activity	PMID:24554735^[1]	ECO:0000315			F		Knockdown of siRhoGDI2 in HTR-8/SVneo cells induced the activation of RAC1 as detected by G-LISA, suggesting that RhoGDI2 inhibits RAC1. In contrast, RhoGDI2 overexpression inhibited the activation of RAC1, Figure 6.	complete CACAO 9541
	GO:1901164	negative regulation of trophoblast cell migration	PMID:24554735^[1]	ECO:0000314			P		Over-expression of RhoGDI2 markedly inhibited the migration of HTR-8/SVneo cells. Knockdown of RhoGDI2 increased the migration of HTR-8/SVneo cells, Figure 5.	complete CACAO 9543
part_of	GO:0005829	cytosol	PMID:10802295^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000249	regulation of actin cytoskeleton reorganization	PMID:8262133^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035023	regulation of Rho protein signal transduction	PMID:8262133^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	PMID:7512369^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035023	regulation of Rho protein signal transduction	PMID:7512369^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005094	Rho GDP-dissociation inhibitor activity	PMID:7512369^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005094	Rho GDP-dissociation inhibitor activity	PMID:8356058^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901164	negative regulation of trophoblast cell migration	PMID:24554735^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:24554735^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000104723 UniProtKB:P52566	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108430 MGI:MGI:2178103 PANTHER:PTN000104723 RGD:1305383 RGD:1359547 WB:WBGene00004356	C		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2178103 PANTHER:PTN000104723	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000104723 RGD:1305383 RGD:1359547 SGD:S000002294 UniProtKB:P52566 UniProtKB:Q99819 UniProtKB:Q9TU03 WB:WBGene00004356 dictyBase:DDB_G0280049 dictyBase:DDB_G0291077	C		Seeded From UniProt	complete
enables	GO:0005094	Rho GDP-dissociation inhibitor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2178103 PANTHER:PTN000104723 SGD:S000002294 UniProtKB:P52566	F		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005094	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005094	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005094	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005094	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005094	P		Seeded From UniProt	complete
involved_in	GO:0071461	cellular response to redox state	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5M860 ensembl:ENSRNOP00000007779	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5M860 ensembl:ENSRNOP00000007779	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5M860 ensembl:ENSRNOP00000007779	C		Seeded From UniProt	complete
enables	GO:0005094	Rho GDP-dissociation inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000406	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000406	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:9113980^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:8434008^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007162	negative regulation of cell adhesion	PMID:9113980^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005094	Rho GDP-dissociation inhibitor activity	PMID:8262133^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:16130169^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16130169^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051056	regulation of small GTPase mediated signal transduction	Reactome:R-HSA-194840	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-195146 Reactome:R-HSA-194854	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0343	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Liu, S et al. (2014) RhoGDI2 is expressed in human trophoblasts and involved in their migration by inhibiting the activation of RAC1. Biol. Reprod. 90 88 PubMed GONUTS page
↑ Davis, AR et al. (2000) Cloning and characterization of bovine low molecular weight GTPases (Rac1 and Rac2) and rho GDP-dissociation inhibitor 2 (D4-GDI). Vet. Immunol. Immunopathol. 74 285-301 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Leffers, H et al. (1993) Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton. Exp. Cell Res. 209 165-74 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Adra, CN et al. (1993) Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I. Genes Chromosomes Cancer 8 253-61 PubMed GONUTS page
↑ Scherle, P et al. (1993) Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 90 7568-72 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^7.0 ^7.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 Adra, CN et al. (1997) RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. Proc. Natl. Acad. Sci. U.S.A. 94 4279-84 PubMed GONUTS page
↑ Lelias, JM et al. (1993) cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 90 1479-83 PubMed GONUTS page
↑ ^11.0 ^11.1 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page

[PMID:24554735-1] 1.0 ^1.1 ^1.2 ^1.3 Liu, S et al. (2014) RhoGDI2 is expressed in human trophoblasts and involved in their migration by inhibiting the activation of RAC1. Biol. Reprod. 90 88 PubMed GONUTS page

[PMID:10802295-2] Davis, AR et al. (2000) Cloning and characterization of bovine low molecular weight GTPases (Rac1 and Rac2) and rho GDP-dissociation inhibitor 2 (D4-GDI). Vet. Immunol. Immunopathol. 74 285-301 PubMed GONUTS page

[PMID:8262133-3] 3.0 ^3.1 ^3.2 Leffers, H et al. (1993) Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton. Exp. Cell Res. 209 165-74 PubMed GONUTS page

[PMID:7512369-4] 4.0 ^4.1 ^4.2 Adra, CN et al. (1993) Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I. Genes Chromosomes Cancer 8 253-61 PubMed GONUTS page

[PMID:8356058-5] Scherle, P et al. (1993) Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 90 7568-72 PubMed GONUTS page

[PMID:19056867-6] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-7] 7.0 ^7.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9113980-9] 9.0 ^9.1 Adra, CN et al. (1997) RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. Proc. Natl. Acad. Sci. U.S.A. 94 4279-84 PubMed GONUTS page

[PMID:8434008-10] Lelias, JM et al. (1993) cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 90 1479-83 PubMed GONUTS page

[PMID:16130169-11] 11.0 ^11.1 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page

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HUMAN:GDIR2

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References

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