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Category:MichSt14A 50

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableHUMAN:IDHPStoloff1, MichSt14A 502014-04-03 12:52:06 CDTGO:0004450 isocitrate dehydrogenase (NADP+) activity (F)PMID:23226729ECO:0000314 direct assay evidence used in manual assertion

Figure 3 depicts the activity of isocitrate dehydrogenase. The over expressed IDH2 plasmid is shown to have the highest amount of activity, supporting the claim that IDH2 over expression is correlated with colon cancer.

challenge
unacceptableHUMAN:TXTPStoloff1, MichSt14A 502014-04-03 12:31:16 CDTGO:0006843 mitochondrial citrate transport (P)PMID:23561848ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 A and B shows a comparison of urine samples of individuals with a recessive mutation to those without the mutation. The graph shows that individuals with the mutation have a lower amount of citrate and isocitrate.

challenge
updatedbyinstructorMOUSE:NF2L2Stoloff1, MichSt14A 502014-04-03 12:08:51 CDTGO:0046326 positive regulation of glucose import (P)PMID:24024172ECO:0000314 direct assay evidence used in manual assertion

Figure 1A shows that the activation of the Nrf2 gene results in an increase in the amount of glucose able to be taken in.

challenge
unacceptableVIBCH:PPKStoloff1, MichSt14A 502014-04-03 11:16:00 CDTGO:0008976 polyphosphate kinase activity (F)PMID:24511696ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4 shows a comparison of the wild type and mutant phenotype when grown in phosphate minimal media. The mutant that had ppk knocked out had a significant lower amount of growth in the minimal media supporting the claim that ppk is necessary for growth in phosphate lacking environments.

challenge
updatedbyinstructorCAEEL:Q93703Stoloff1, MichSt14A 502014-04-03 10:56:04 CDTGO:0043053 dauer entry (P)PMID:24385923ECO:0000316 genetic interaction evidence used in manual assertion

Figure 2, 3.

challenge

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