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HUMAN:IDHP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IDH2
Protein Name(s) Isocitrate dehydrogenase [NADP], mitochondrial

IDH ICD-M IDP NADP(+)-specific ICDH Oxalosuccinate decarboxylase

External Links
UniProt P48735
EMBL X69433
AK294148
AK312627
AK316388
AC087284
AC092769
CH471101
BC009244
BC071828
CCDS CCDS10359.1
PIR S57499
RefSeq NP_001276839.1
NP_001277043.1
NP_002159.2
UniGene Hs.596461
PDB 4JA8
PDBsum 4JA8
ProteinModelPortal P48735
SMR P48735
BioGrid 109644
IntAct P48735
MINT MINT-3016964
STRING 9606.ENSP00000331897
PhosphoSite P48735
DMDM 20141568
OGP P48735
UCD-2DPAGE P48735
MaxQB P48735
PaxDb P48735
PeptideAtlas P48735
PRIDE P48735
DNASU 3418
Ensembl ENST00000330062
ENST00000540499
GeneID 3418
KEGG hsa:3418
UCSC uc002box.3
CTD 3418
GeneCards GC15M090626
HGNC HGNC:5383
HPA HPA007831
MIM 147650
613657
neXtProt NX_P48735
Orphanet 79315
296
163634
PharmGKB PA29631
eggNOG COG0538
GeneTree ENSGT00390000012547
HOGENOM HOG000019858
HOVERGEN HBG006119
InParanoid P48735
KO K00031
OMA QVIEHDV
OrthoDB EOG7QNVKS
PhylomeDB P48735
TreeFam TF300428
BioCyc MetaCyc:HS00021-MONOMER
Reactome REACT_1785
ChiTaRS IDH2
GeneWiki IDH2
GenomeRNAi 3418
NextBio 13474
PRO PR:P48735
Proteomes UP000005640
Bgee P48735
CleanEx HS_IDH2
ExpressionAtlas P48735
Genevestigator P48735
GO GO:0070062
GO:0005743
GO:0005759
GO:0005739
GO:0004450
GO:0000287
GO:0051287
GO:0006103
GO:0005975
GO:0044237
GO:0006097
GO:0006102
GO:0044281
GO:0006099
Gene3D 3.40.718.10
InterPro IPR019818
IPR004790
IPR024084
PANTHER PTHR11822
Pfam PF00180
PIRSF PIRSF000108
TIGRFAMs TIGR00127
PROSITE PS00470

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004450

isocitrate dehydrogenase (NADP+) activity

PMID:23226729[1]

ECO:0000314

F

Figure 3 depicts the activity of isocitrate dehydrogenase. The over expressed IDH2 plasmid is shown to have the highest amount of activity, supporting the claim that IDH2 over expression is correlated with colon cancer.

complete
CACAO 9781

enables

GO:0004450

isocitrate dehydrogenase (NADP+) activity

PMID:23226729[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:20833797[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001134)

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

PMID:8954790[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006103

2-oxoglutarate metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75874

P

Seeded From UniProt

complete

involved_in

GO:0006102

isocitrate metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75874

P

Seeded From UniProt

complete

enables

GO:0004450

isocitrate dehydrogenase (NADP+) activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75874

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75874

F

Seeded From UniProt

complete

involved_in

GO:0006739

NADP metabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000214400
TAIR:locus:2009759

P

Seeded From UniProt

complete

involved_in

GO:0006102

isocitrate metabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000214400
RGD:2862
SGD:S000004164
TAIR:locus:2009759
UniProtKB:O75874
UniProtKB:P9WKL1

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002483528
UniProtKB:P48735
UniProtKB:Q8I6T2

C

Seeded From UniProt

complete

enables

GO:0004450

isocitrate dehydrogenase (NADP+) activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96413
MGI:MGI:96414
PANTHER:PTN000214400
RGD:1597139
RGD:2862
SGD:S000002224
SGD:S000004164
SGD:S000004954
TAIR:locus:2009759
UniProtKB:O75874
UniProtKB:P48735
UniProtKB:P9WKL1

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54071
ensembl:ENSMUSP00000103007

C

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54071
ensembl:ENSMUSP00000103007

C

Seeded From UniProt

complete

enables

GO:0004450

isocitrate dehydrogenase (NADP+) activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54071
ensembl:ENSMUSP00000103007

F

Seeded From UniProt

complete

enables

GO:0004448

isocitrate dehydrogenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54071
ensembl:ENSMUSP00000103007

F

Seeded From UniProt

complete

involved_in

GO:1904465

negative regulation of matrix metallopeptidase secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56574
ensembl:ENSRNOP00000019059

P

Seeded From UniProt

complete

involved_in

GO:1903976

negative regulation of glial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56574
ensembl:ENSRNOP00000019059

P

Seeded From UniProt

complete

involved_in

GO:0060253

negative regulation of glial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56574
ensembl:ENSRNOP00000019059

P

Seeded From UniProt

complete

involved_in

GO:0006741

NADP biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56574
ensembl:ENSRNOP00000019059

P

Seeded From UniProt

complete

enables

GO:0004450

isocitrate dehydrogenase (NADP+) activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56574
ensembl:ENSRNOP00000019059

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019818

F

Seeded From UniProt

complete

enables

GO:0004450

isocitrate dehydrogenase (NADP+) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004790

F

Seeded From UniProt

complete

involved_in

GO:0006102

isocitrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004790

P

Seeded From UniProt

complete

enables

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019818
InterPro:IPR024084

F

Seeded From UniProt

complete

enables

GO:0051287

NAD binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019818

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004790
InterPro:IPR019818
InterPro:IPR024084

P

Seeded From UniProt

complete

enables

GO:0004450

isocitrate dehydrogenase (NADP+) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.42

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

Reactome:R-HSA-71403

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-5688289
Reactome:R-HSA-450984

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0816

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006097

glyoxylate cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0329

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Lv, Q et al. (2012) Altered expression levels of IDH2 are involved in the development of colon cancer. Exp Ther Med 4 801-806 PubMed GONUTS page
  2. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. ↑ Zhao, X et al. (2011) Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Mol. Cell Proteomics 10 M110.000299 PubMed GONUTS page
  4. ↑ Oh, IU et al. (1996) Assignment of the human mitochondrial NADP(+)-specific isocitrate dehydrogenase (IDH2) gene to 15q26.1 by in situ hybridization. Genomics 38 104-6 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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