Category:GO:0160218 ! negative regulation of pyruvate decarboxylation to acetyl-CoA

name: negative regulation of pyruvate decarboxylation to acetyl-CoA
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions." [PMID:26942675, PMID:36849569, PMID:37754565]
synonym: "negative regulation of acetyl-CoA biosynthetic process from pyruvate" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010510 ! regulation of pyruvate decarboxylation to acetyl-CoA
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates: GO:0006086 ! pyruvate decarboxylation to acetyl-CoA
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006086 ! pyruvate decarboxylation to acetyl-CoA

AmiGO <GOterm>GO:0160218</GOterm>
Gene Ontology Home