Category:GO:0006086 ! pyruvate decarboxylation to acetyl-CoA

name: pyruvate decarboxylation to acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH." [MetaCyc:PYRUVDEHYD-PWY]
synonym: "acetyl-CoA anabolism from pyruvate" EXACT []
synonym: "acetyl-CoA biosynthetic process from pyruvate" EXACT []
synonym: "acetyl-CoA formation from pyruvate" EXACT []
synonym: "acetyl-CoA synthesis from pyruvate" EXACT []
synonym: "oxidative decarboxylation of pyruvate" EXACT []
synonym: "pyruvate decarboxylation" NARROW []
synonym: "pyruvate dehydrogenase pathway" EXACT []
xref: MetaCyc:PYRUVDEHYD-PWY
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0006090 ! pyruvate metabolic process
relationship: has_part: GO:0004148 ! dihydrolipoyl dehydrogenase (NADH) activity
relationship: has_part: GO:0004739 ! pyruvate dehydrogenase (acetyl-transferring) activity
relationship: has_part: GO:0004742 ! dihydrolipoyllysine-residue acetyltransferase activity
relationship: part_of: GO:0009060 ! aerobic respiration

AmiGO <GOterm>GO:0006086</GOterm>
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