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Category:GO:0043514 ! interleukin-12 complex
name: interleukin-12 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space." [GOC:add, GOC:ebc, GOC:mah, PMID:12948519, PMID:1381512]
comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
synonym: "IL-12 complex" EXACT [GOC:mah]
synonym: "IL12A" NARROW [GOC:add]
synonym: "IL12B" NARROW [GOC:add]
synonym: "p35" NARROW [GOC:add]
synonym: "p40" NARROW [GOC:add]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of: GO:0005615 ! extracellular space
AmiGO
<GOterm>GO:0043514</GOterm>
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