CHICK:Q6X0K9

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	IL12B (ECO:0000313 with Ensembl:ENSGALP00000002143) (synonyms: IL-12B (ECO:0000313 with EMBL:ACY72342.1))
Protein Name(s)	Interleukin-12 subunit beta (ECO:0000256 with RuleBase:RU281113) Cytotoxic lymphocyte maturation factor 40 kDa subunit (ECO:0000256 with RuleBase:RU281113) IL-12 subunit p40 (ECO:0000256 with RuleBase:RU281113)
External Links
UniProt	Q6X0K9
EMBL	AADN03006674 AY262752 DQ202328 FJ788636
RefSeq	NP_998736.1
UniGene	Gga.14433
STRING	9031.ENSGALP00000040257
Ensembl	ENSGALT00000002145 ENSGALT00000041052
GeneID	404671
KEGG	gga:404671
CTD	3593
eggNOG	NOG45642
GeneTree	ENSGT00390000012630
HOGENOM	HOG000113027
HOVERGEN	HBG052094
KO	K05425
OMA	WSTPHSY
OrthoDB	EOG7TBC2K
PhylomeDB	Q6X0K9
TreeFam	TF334829
NextBio	20817697
PRO	PR:Q6X0K9
Proteomes	UP000000539
GO	GO:0005737 GO:0043514 GO:0070743 GO:0007050 GO:0016477 GO:0007166 GO:0071346 GO:0071222 GO:0050829 GO:0042832 GO:0051607 GO:0030101 GO:0044130 GO:0002862 GO:0032693 GO:0032700 GO:0048662 GO:0042104 GO:0010535 GO:0045785 GO:0002230 GO:0032725 GO:0032729 GO:0032733 GO:0032735 GO:0032740 GO:0002860 GO:0032819 GO:0051135 GO:0051142 GO:0045672 GO:0034393 GO:0001916 GO:0002827 GO:0032760 GO:0042517 GO:0042520 GO:0042523 GO:0042510 GO:0010224 GO:0042093
Gene3D	2.60.40.10
InterPro	IPR003961 IPR007110 IPR013783 IPR015528 IPR019482
PANTHER	PTHR11321
Pfam	PF10420
PIRSF	PIRSF038007
PRINTS	PR01928
SUPFAM	SSF49265
PROSITE	PS50853 PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0032609	interferon-gamma production	PMID:15034052^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q6X0L0	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:15034052^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070417	cellular response to cold	PMID:16150487^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
part_of	GO:0070743	interleukin-23 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	C	Seeded From UniProt	complete
involved_in	GO:0051142	positive regulation of NK T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0051135	positive regulation of NK T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0050671	positive regulation of lymphocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	F	Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
enables	GO:0045519	interleukin-23 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	F	Seeded From UniProt	complete
part_of	GO:0043514	interleukin-12 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	F	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
enables	GO:0042164	interleukin-12 alpha subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	F	Seeded From UniProt	complete
involved_in	GO:0042104	positive regulation of activated T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0042093	T-helper cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0034393	positive regulation of smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032946	positive regulation of mononuclear cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032819	positive regulation of natural killer cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032816	positive regulation of natural killer cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032700	negative regulation of interleukin-17 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0032693	negative regulation of interleukin-10 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0030101	natural killer cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0010536	positive regulation of activation of Janus kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0010224	response to UV-B	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	F	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	F	Seeded From UniProt	complete
involved_in	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0002827	positive regulation of T-helper 1 type immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0002230	positive regulation of defense response to virus by host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29460 ensembl:ENSP00000231228	P	Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
part_of	GO:0070743	interleukin-23 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	C	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
involved_in	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
part_of	GO:0043514	interleukin-12 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	C	Seeded From UniProt	complete
involved_in	GO:0042832	defense response to protozoan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	F	Seeded From UniProt	complete
enables	GO:0042164	interleukin-12 alpha subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	F	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
involved_in	GO:0035744	T-helper 1 cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
involved_in	GO:0032609	interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	C	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	C	Seeded From UniProt	complete
enables	GO:0005126	cytokine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	F	Seeded From UniProt	complete
involved_in	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
involved_in	GO:0002827	positive regulation of T-helper 1 type immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
involved_in	GO:0002230	positive regulation of defense response to virus by host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
involved_in	GO:0001916	positive regulation of T cell mediated cytotoxicity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43432 ensembl:ENSMUSP00000125867	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0004896	cytokine receptor activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000076458	F	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000076458	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Degen, WG et al. (2004) Identification and molecular cloning of functional chicken IL-12. J. Immunol. 172 4371-80 PubMed GONUTS page
↑ Hangalapura, BN et al. (2006) Cold stress equally enhances in vivo pro-inflammatory cytokine gene expression in chicken lines divergently selected for antibody responses. Dev. Comp. Immunol. 30 503-11 PubMed GONUTS page

[PMID:15034052-1] 1.0 ^1.1 Degen, WG et al. (2004) Identification and molecular cloning of functional chicken IL-12. J. Immunol. 172 4371-80 PubMed GONUTS page

[PMID:16150487-2] Hangalapura, BN et al. (2006) Cold stress equally enhances in vivo pro-inflammatory cytokine gene expression in chicken lines divergently selected for antibody responses. Dev. Comp. Immunol. 30 503-11 PubMed GONUTS page

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CHICK:Q6X0K9

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