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Category:GO:0043224 ! nuclear SCF ubiquitin ligase complex

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DAG for GO:0043224id: GO:0043224

name: nuclear SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
synonym: "nuclear cullin complex" EXACT []
synonym: "nuclear SCF complex" EXACT []
synonym: "nuclear Skp1/Cul1/F-box protein complex" EXACT []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0019005 ! SCF ubiquitin ligase complex
intersection_of: GO:0019005 ! SCF ubiquitin ligase complex
intersection_of: part_of GO:0005634 ! nucleus

AmiGO <GOterm>GO:0043224</GOterm>
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