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Category:GO:0039530 ! MDA-5 signaling pathway
name: MDA-5 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines." [GOC:bf, PMID:19620789, PMID:33087405]
synonym: "IFIH1 signaling pathway" EXACT [HGNC:18873]
synonym: "MDA-5 signalling pathway" EXACT [GOC:mah]
synonym: "MDA5 signaling pathway" NARROW [PMID:17328678]
synonym: "melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873]
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway
AmiGO
<GOterm>GO:0039530</GOterm>
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This category has the following 2 subcategories, out of 2 total.
