name: MDA-5 signaling pathway
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def: "Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:19620789]
synonym: "IFIH1 signaling pathway" EXACT [HGNC:18873]
synonym: "MDA-5 signalling pathway" EXACT [GOC:mah]
synonym: "MDA5 signaling pathway" NARROW [PMID:17328678]
synonym: "melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873]
is_a: GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus
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