CVHSA:R1AB

Species (Taxon ID)	Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndromecoronavirus). (227859)
Gene Name(s)	rep
Protein Name(s)	Replicase polyprotein 1ab pp1ab ORF1ab polyprotein Host translation inhibitor nsp1 nsp1 Leader protein Non-structural protein 2 nsp2 p65 homolog Papain-like proteinase PL-PRO Non-structural protein 3 nsp3 PL2-PRO SARS coronavirus main proteinase Non-structural protein 4 nsp4 3C-like proteinase 3CL-PRO 3CLp nsp5 Non-structural protein 6 nsp6 Non-structural protein 7 nsp7 Non-structural protein 8 nsp8 Non-structural protein 9 nsp9 Non-structural protein 10 nsp10 Growth factor-like peptide GFL RNA-directed RNA polymerase Pol RdRp nsp12 Helicase Hel nsp13 Guanine-N7 methyltransferase ExoN nsp14 Uridylate-specific endoribonuclease NendoU nsp15 2'-O-methyltransferase nsp16
External Links
UniProt	P0C6X7
EMBL	AY278741 AY278741 AY274119 AY278554 AY282752 AY304495 AY304486 AY304488 AY278491 AY283794 AY283795 AY283796 AY283797 AY283798 AY286320 AY278488 AY278489 AY278490 AY279354 AY291451 AY310120 AY291315 AY323977 AY321118 AY338174 AY338174 AY338175 AY338175 AY348314 AY348314 AP006557 AP006558 AP006559 AP006560 AP006561 AY427439 AY322205 AY322206 AY322207 AY463059 AY269391 AY268049
RefSeq	NP_828849.2
PDB	1O5S 1P76 1P9T 1PA5 1PUK 1Q1X 1Q2W 1QZ8 1SXF 1UJ1 1UK2 1UK3 1UK4 1UW7 1WOF 1YSY 1Z1I 1Z1J 2A5A 2A5I 2A5K 2ACF 2AHM 2AJ5 2ALV 2AMD 2AMQ 2BX3 2BX4 2C3S 2D2D 2DUC 2FAV 2FE8 2FYG 2G1F 2G9T 2GA6 2GDT 2GRI 2GT7 2GT8 2GTB 2GX4 2GZ7 2GZ8 2GZ9 2H2Z 2H85 2HOB 2HSX 2IDY 2JZD 2JZE 2JZF 2K87 2OP9 2OZK 2PWX 2Q6G 2QC2 2QCY 2QIQ 2RHB 2RNK 2V6N 2VJ1 2XYQ 2XYR 2XYV 2YY4 2Z3C 2Z3D 2Z3E 2Z94 2Z9G 2Z9J 2Z9K 2Z9L 3D62 3E9S 3EBN 3R24
PDBsum	1O5S 1P76 1P9T 1PA5 1PUK 1Q1X 1Q2W 1QZ8 1SXF 1UJ1 1UK2 1UK3 1UK4 1UW7 1WOF 1YSY 1Z1I 1Z1J 2A5A 2A5I 2A5K 2ACF 2AHM 2AJ5 2ALV 2AMD 2AMQ 2BX3 2BX4 2C3S 2D2D 2DUC 2FAV 2FE8 2FYG 2G1F 2G9T 2GA6 2GDT 2GRI 2GT7 2GT8 2GTB 2GX4 2GZ7 2GZ8 2GZ9 2H2Z 2H85 2HOB 2HSX 2IDY 2JZD 2JZE 2JZF 2K87 2OP9 2OZK 2PWX 2Q6G 2QC2 2QCY 2QIQ 2RHB 2RNK 2V6N 2VJ1 2XYQ 2XYR 2XYV 2YY4 2Z3C 2Z3D 2Z3E 2Z94 2Z9G 2Z9J 2Z9K 2Z9L 3D62 3E9S 3EBN 3R24
ProteinModelPortal	P0C6X7
SMR	P0C6X7
MINT	MINT-1487760
BindingDB	P0C6X7
ChEMBL	CHEMBL5118
PRIDE	P0C6X7
GeneID	1489680
EvolutionaryTrace	P0C6X7
Proteomes	UP000000354
GO	GO:0044172 GO:0033644 GO:0044220 GO:0016021 GO:0000175 GO:0005524 GO:0004197 GO:0004519 GO:0004386 GO:1990380 GO:0008168 GO:0004482 GO:0004483 GO:0008242 GO:0003723 GO:0003968 GO:0003727 GO:0008270 GO:0006370 GO:0039595 GO:0039520 GO:0008152 GO:0039519 GO:0039648 GO:0080009 GO:2000158 GO:0071108 GO:0036265 GO:0090503 GO:0039549 GO:0039579 GO:0039644 GO:0039604 GO:0039502 GO:0006351 GO:0001172 GO:0019082 GO:0039694 GO:0019083
Gene3D	3.40.50.300
InterPro	IPR027351 IPR009461 IPR027352 IPR002589 IPR021590 IPR009466 IPR024375 IPR014828 IPR014829 IPR014822 IPR027417 IPR008740 IPR013016 IPR001205 IPR007094 IPR009469 IPR018995 IPR029063 IPR024358 IPR022733 IPR009003 IPR014827
Pfam	PF06478 PF12379 PF01661 PF11501 PF09401 PF06471 PF06460 PF12124 PF08716 PF08717 PF08710 PF05409 PF00680 PF11633 PF01443 PF08715
SUPFAM	SSF101816 SSF144246 SSF50494 SSF52540 SSF53335
PROSITE	PS51653 PS51442 PS51154 PS51124 PS51657 PS50507

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0000175	3'-5'-exoribonuclease activity	PMID:16549795^[1]	ECO:0000314			F	Fig. 3 and Fig. 4	complete CACAO 2448
	GO:0019083	viral transcription	PMID:16549795^[1]	ECO:0000315			P	Fig. 5	complete CACAO 2449
involved_in	GO:0019083	viral transcription	PMID:16549795^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000175	3'-5'-exoribonuclease activity	PMID:16549795^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16271890^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0C6X7	F	Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P	Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P	Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004527	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt	complete
involved_in	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016896	P	Seeded From UniProt	complete
involved_in	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0000175	P	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032592	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009469 InterPro:IPR014822 InterPro:IPR018995 InterPro:IPR036333	F	Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007094 InterPro:IPR009466 InterPro:IPR009469 InterPro:IPR013016	F	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009466 InterPro:IPR014827 InterPro:IPR014828 InterPro:IPR014829 InterPro:IPR022733 InterPro:IPR037204 InterPro:IPR037230	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009469 InterPro:IPR027351	F	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009469	P	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013016	P	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009466	F	Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013016	F	Seeded From UniProt	complete
enables	GO:0008242	omega peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014827 InterPro:IPR014828 InterPro:IPR014829 InterPro:IPR037204 InterPro:IPR037230	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018995 InterPro:IPR027352 InterPro:IPR036333	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014827 InterPro:IPR014828 InterPro:IPR014829 InterPro:IPR037204 InterPro:IPR037230	F	Seeded From UniProt	complete
enables	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009466	F	Seeded From UniProt	complete
involved_in	GO:0019079	viral genome replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014822 InterPro:IPR018995 InterPro:IPR036333	P	Seeded From UniProt	complete
involved_in	GO:0019082	viral protein processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008740	P	Seeded From UniProt	complete
involved_in	GO:0039694	viral RNA genome replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007094	P	Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.48	F	Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.4.19.12	F	Seeded From UniProt	complete
involved_in	GO:0039604	suppression by virus of host translation	PMID:23035226^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0039714	cytoplasmic viral factory	PMID:23943763^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	PMID:19369340^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039648	modulation by virus of host protein ubiquitination	PMID:16306590^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000158	positive regulation of ubiquitin-specific protease activity	PMID:16306590^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:1990380	Lys48-specific deubiquitinase activity	PMID:24854014^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0039579	suppression by virus of host ISG15 activity	PMID:17692280^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039644	suppression by virus of host NF-kappaB transcription factor activity	PMID:19369340^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039548	suppression by virus of host IRF3 activity	PMID:19369340^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071108	protein K48-linked deubiquitination	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1990380	P	Seeded From UniProt	complete
part_of	GO:0039714	cytoplasmic viral factory	PMID:23943763^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0039519	modulation by virus of host autophagy	PMID:24991833^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039690	positive stranded viral RNA replication	PMID:22039154^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	PMID:22039154^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0039690	positive stranded viral RNA replication	PMID:22039154^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003727	single-stranded RNA binding	PMID:19153232^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0039690	positive stranded viral RNA replication	PMID:19875418^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	PMID:19875418^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003727	single-stranded RNA binding	PMID:19875418^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	PMID:22791111^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	PMID:22791111^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	PMID:12917423^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	PMID:22635272^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000175	3'-5'-exoribonuclease activity	PMID:22635272^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	PMID:19208801^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006370	7-methylguanosine mRNA capping	PMID:19208801^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0106005	RNA 5'-cap (guanine-N7)-methylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004482	P	Seeded From UniProt	complete
involved_in	GO:0080009	mRNA methylation	PMID:18417574^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	PMID:18417574^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0039714	cytoplasmic viral factory	PMID:23943763^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0039520	induction by virus of host autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1072	P	Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043 UniProtKB-SubCell:SL-0380	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1190	P	Seeded From UniProt	complete
involved_in	GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1114	P	Seeded From UniProt	complete
involved_in	GO:0039503	suppression by virus of host innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1090	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0696	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P	Seeded From UniProt	complete
involved_in	GO:0039648	modulation by virus of host protein ubiquitination	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1127 UniProtKB-KW:KW-1130	P	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt	complete
involved_in	GO:0039579	suppression by virus of host ISG15 activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1095	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0039644	suppression by virus of host NF-kappaB transcription factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1100	P	Seeded From UniProt	complete
involved_in	GO:0039595	induction by virus of catabolism of host mRNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1132	P	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt	complete
enables	GO:0004527	exonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0269	F	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035 UniProtKB-SubCell:SL-0381	C	Seeded From UniProt	complete
involved_in	GO:0030683	evasion or tolerance by virus of host immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0899	P	Seeded From UniProt	complete
part_of	GO:0044172	host cell endoplasmic reticulum-Golgi intermediate compartment	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0391	C	Seeded From UniProt	complete
part_of	GO:0044220	host cell perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0382	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Minskaia, E et al. (2006) Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc. Natl. Acad. Sci. U.S.A. 103 5108-13 PubMed GONUTS page
↑ Saikatendu, KS et al. (2005) Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1-phosphate dephosphorylation by a conserved domain of nsP3. Structure 13 1665-75 PubMed GONUTS page
↑ Lokugamage, KG et al. (2012) Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation. J. Virol. 86 13598-608 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Angelini, MM et al. (2013) Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles. MBio 4 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Frieman, M et al. (2009) Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling. J. Virol. 83 6689-705 PubMed GONUTS page
↑ ^6.0 ^6.1 Barretto, N et al. (2005) The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J. Virol. 79 15189-98 PubMed GONUTS page
↑ Ratia, K et al. (2014) Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease. PLoS Pathog. 10 e1004113 PubMed GONUTS page
↑ Lindner, HA et al. (2007) Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease. Arch. Biochem. Biophys. 466 8-14 PubMed GONUTS page
↑ Cottam, EM et al. (2014) Coronavirus NSP6 restricts autophagosome expansion. Autophagy 10 1426-41 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 te Velthuis, AJ et al. (2012) The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension. Nucleic Acids Res. 40 1737-47 PubMed GONUTS page
↑ Miknis, ZJ et al. (2009) Severe acute respiratory syndrome coronavirus nsp9 dimerization is essential for efficient viral growth. J. Virol. 83 3007-18 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 te Velthuis, AJ et al. (2010) The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent. Nucleic Acids Res. 38 203-14 PubMed GONUTS page
↑ ^13.0 ^13.1 Ahn, DG et al. (2012) Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates. Arch. Virol. 157 2095-104 PubMed GONUTS page
↑ Tanner, JA et al. (2003) The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases. J. Biol. Chem. 278 39578-82 PubMed GONUTS page
↑ ^15.0 ^15.1 Bouvet, M et al. (2012) RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex. Proc. Natl. Acad. Sci. U.S.A. 109 9372-7 PubMed GONUTS page
↑ ^16.0 ^16.1 Chen, Y et al. (2009) Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proc. Natl. Acad. Sci. U.S.A. 106 3484-9 PubMed GONUTS page
↑ ^17.0 ^17.1 Decroly, E et al. (2008) Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity. J. Virol. 82 8071-84 PubMed GONUTS page

[PMID:16549795-1] 1.0 ^1.1 ^1.2 ^1.3 Minskaia, E et al. (2006) Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc. Natl. Acad. Sci. U.S.A. 103 5108-13 PubMed GONUTS page

[PMID:16271890-2] Saikatendu, KS et al. (2005) Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1-phosphate dephosphorylation by a conserved domain of nsP3. Structure 13 1665-75 PubMed GONUTS page

[PMID:23035226-3] Lokugamage, KG et al. (2012) Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation. J. Virol. 86 13598-608 PubMed GONUTS page

[PMID:23943763-4] 4.0 ^4.1 ^4.2 Angelini, MM et al. (2013) Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles. MBio 4 PubMed GONUTS page

[PMID:19369340-5] 5.0 ^5.1 ^5.2 Frieman, M et al. (2009) Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling. J. Virol. 83 6689-705 PubMed GONUTS page

[PMID:16306590-6] 6.0 ^6.1 Barretto, N et al. (2005) The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J. Virol. 79 15189-98 PubMed GONUTS page

[PMID:24854014-7] Ratia, K et al. (2014) Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease. PLoS Pathog. 10 e1004113 PubMed GONUTS page

[PMID:17692280-8] Lindner, HA et al. (2007) Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease. Arch. Biochem. Biophys. 466 8-14 PubMed GONUTS page

[PMID:24991833-9] Cottam, EM et al. (2014) Coronavirus NSP6 restricts autophagosome expansion. Autophagy 10 1426-41 PubMed GONUTS page

[PMID:22039154-10] 10.0 ^10.1 ^10.2 te Velthuis, AJ et al. (2012) The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension. Nucleic Acids Res. 40 1737-47 PubMed GONUTS page

[PMID:19153232-11] Miknis, ZJ et al. (2009) Severe acute respiratory syndrome coronavirus nsp9 dimerization is essential for efficient viral growth. J. Virol. 83 3007-18 PubMed GONUTS page

[PMID:19875418-12] 12.0 ^12.1 ^12.2 te Velthuis, AJ et al. (2010) The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent. Nucleic Acids Res. 38 203-14 PubMed GONUTS page

[PMID:22791111-13] 13.0 ^13.1 Ahn, DG et al. (2012) Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates. Arch. Virol. 157 2095-104 PubMed GONUTS page

[PMID:12917423-14] Tanner, JA et al. (2003) The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases. J. Biol. Chem. 278 39578-82 PubMed GONUTS page

[PMID:22635272-15] 15.0 ^15.1 Bouvet, M et al. (2012) RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex. Proc. Natl. Acad. Sci. U.S.A. 109 9372-7 PubMed GONUTS page

[PMID:19208801-16] 16.0 ^16.1 Chen, Y et al. (2009) Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proc. Natl. Acad. Sci. U.S.A. 106 3484-9 PubMed GONUTS page

[PMID:18417574-17] 17.0 ^17.1 Decroly, E et al. (2008) Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity. J. Virol. 82 8071-84 PubMed GONUTS page

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