GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

CSFVA:POLG

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Classical swine fever virus (strain Alfort) (CSFV) (Hog choleravirus). (11097)
Gene Name(s) No Information Provided.
Protein Name(s) Genome polyprotein

N-terminal protease N-pro Autoprotease p20 Capsid protein C Core protein E(rns) glycoprotein gp44/48 Envelope glycoprotein E1 gp33 Envelope glycoprotein E2 gp55 p7 Non-structural protein 2-3 NS2-3 Cysteine protease NS2 Non-structural protein 2 Serine protease NS3 Non-structural protein 3 Non-structural protein 4A NS4A Non-structural protein 4B NS4B Non-structural protein 5A NS5A RNA-directed RNA polymerase NS5B

External Links
UniProt P19712
EMBL J04358
PDB 4CBG
4CBH
4CBI
4CBL
4CBM
5MZ4
PDBsum 4CBG
4CBH
4CBI
4CBL
4CBM
5MZ4
ProteinModelPortal P19712
SMR P19712
IntAct P19712
MEROPS C53.001
PRIDE P19712
PMAP-CutDB P19712
Proteomes UP000008568
GO GO:0030430
GO:0044165
GO:0042025
GO:0020002
GO:0044228
GO:0016021
GO:0044385
GO:0019013
GO:0055036
GO:0005524
GO:0008026
GO:0004197
GO:0008234
GO:0005216
GO:0004540
GO:0033897
GO:0003723
GO:0003968
GO:0004252
GO:0070008
GO:0039654
GO:0039520
GO:1990214
GO:0032688
GO:0039707
GO:1990219
GO:1901800
GO:0051259
GO:1903608
GO:0006508
GO:0010468
GO:0090501
GO:0039548
GO:0039644
GO:0039547
GO:0039501
GO:0039502
GO:0019082
GO:0039694
GO:0019062
CDD cd00079
Gene3D 3.90.730.10
InterPro IPR021824
IPR011492
IPR014001
IPR001650
IPR022120
IPR030399
IPR027417
IPR008751
IPR032521
IPR000280
IPR007094
IPR002166
IPR036430
IPR033130
Pfam PF11889
PF07652
PF00271
PF05550
PF12387
PF05578
PF16329
PF00998
PRINTS PR00729
SMART SM00487
SM00490
SUPFAM SSF52540
SSF55895
PROSITE PS51192
PS51194
PS51692
PS51535
PS51876
PS50507
PS00531

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0001172

transcription, RNA-templated

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003968

P

Seeded From UniProt

involved_in

GO:0001172

transcription, RNA-templated

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003968

P

Seeded From UniProt

involved_in

GO:0001172

transcription, RNA-templated

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003968

P

Seeded From UniProt

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005216

P

Seeded From UniProt

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0033897

P

Seeded From UniProt

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002166
InterPro:IPR036430

F

Seeded From UniProt

enables

GO:0003968

RNA-directed 5'-3' RNA polymerase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002166
InterPro:IPR007094
InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

enables

GO:0004175

endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030399

F

Seeded From UniProt

enables

GO:0004197

cysteine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000280
InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011492

F

Seeded From UniProt

enables

GO:0008026

ATP-dependent helicase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011492

F

Seeded From UniProt

involved_in

GO:0016032

viral process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008751

P

Seeded From UniProt

enables

GO:0016817

hydrolase activity, acting on acid anhydrides

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

enables

GO:0017111

nucleoside-triphosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

involved_in

GO:0019082

viral protein processing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008751

P

Seeded From UniProt

enables

GO:0033897

ribonuclease T2 activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR036430

F

Seeded From UniProt

involved_in

GO:0039694

viral RNA genome replication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002166
InterPro:IPR007094

P

Seeded From UniProt

enables

GO:0070008

serine-type exopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

enables

GO:0017111

nucleoside-triphosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.6.1.15

F

Seeded From UniProt

enables

GO:0003968

RNA-directed 5'-3' RNA polymerase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.7.48

F

Seeded From UniProt

involved_in

GO:0006508

proteolysis

PMID:24606708[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0008234

cysteine-type peptidase activity

PMID:24606708[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

involved_in

GO:0039548

suppression by virus of host IRF3 activity

PMID:17215286[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0030430

host cell cytoplasm

PMID:17215286[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:1901800

positive regulation of proteasomal protein catabolic process

PMID:25809915[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1990214

negative regulation by symbiont of host protein levels

PMID:25809915[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039501

suppression by virus of host type I interferon production

PMID:25809915[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039548

suppression by virus of host IRF3 activity

PMID:19540847[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0032688

negative regulation of interferon-beta production

PMID:19540847[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1990214

negative regulation by symbiont of host protein levels

PMID:17215286[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1990219

positive regulation by symbiont of host protein levels

PMID:24965446[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0030430

host cell cytoplasm

PMID:24965446[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0042025

host cell nucleus

PMID:24965446[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:1903608

protein localization to cytoplasmic stress granule

PMID:24965446[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039502

suppression by virus of host type I interferon-mediated signaling pathway

PMID:19767841[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039502

suppression by virus of host type I interferon-mediated signaling pathway

PMID:28290554[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0019013

viral nucleocapsid

PMID:1870198[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0010468

regulation of gene expression

PMID:9617770[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

PMID:8356450[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0004540

ribonuclease activity

PMID:8356450[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

involved_in

GO:0039707

pore formation by virus in membrane of host cell

PMID:24189547[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039547

suppression by virus of host TRAF activity

PMID:28751780[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039644

suppression by virus of host NF-kappaB transcription factor activity

PMID:28751780[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0044165

host cell endoplasmic reticulum

PMID:26748656[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

involved_in

GO:0039654

fusion of virus membrane with host endosome membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1170

P

Seeded From UniProt

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

part_of

GO:0030430

host cell cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1035
UniProtKB-SubCell:SL-0381

C

Seeded From UniProt

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

involved_in

GO:0051259

protein complex oligomerization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1182

P

Seeded From UniProt

part_of

GO:0033644

host cell membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1043
UniProtKB-SubCell:SL-0380

C

Seeded From UniProt

involved_in

GO:0039548

suppression by virus of host IRF3 activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1092

P

Seeded From UniProt

enables

GO:0016779

nucleotidyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0548

F

Seeded From UniProt

part_of

GO:0044385

integral to membrane of host cell

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1182

C

Seeded From UniProt

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

involved_in

GO:0030683

evasion or tolerance by virus of host immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0899

P

Seeded From UniProt

enables

GO:0003968

RNA-directed 5'-3' RNA polymerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0696

F

Seeded From UniProt

part_of

GO:0020002

host cell plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1032
UniProtKB-SubCell:SL-0375

C

Seeded From UniProt

involved_in

GO:0046718

viral entry into host cell

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1160
UniProtKB-KW:KW-1162

P

Seeded From UniProt

involved_in

GO:0039503

suppression by virus of host innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1090

P

Seeded From UniProt

enables

GO:0004386

helicase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0347

F

Seeded From UniProt

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

involved_in

GO:0039707

pore formation by virus in membrane of host cell

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1182

P

Seeded From UniProt

part_of

GO:0019012

virion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0946
UniProtKB-SubCell:SL-0274

C

Seeded From UniProt

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

involved_in

GO:0039663

membrane fusion involved in viral entry into host cell

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1168

P

Seeded From UniProt

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

involved_in

GO:0019062

virion attachment to host cell

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1161

P

Seeded From UniProt

involved_in

GO:0039520

induction by virus of host autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1072

P

Seeded From UniProt

enables

GO:0005216

ion channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1182

F

Seeded From UniProt

part_of

GO:0055036

virion membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0275

C

Seeded From UniProt

part_of

GO:0044228

host cell surface

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0378

C

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:26748656[13]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:F1S912

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:24965446[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q08211

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:24965446[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P67809

F

Seeded From UniProt

involved_in

GO:0001172

transcription, RNA-templated

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003968

P

Seeded From UniProt

involved_in

GO:0001172

transcription, RNA-templated

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003968

P

Seeded From UniProt

involved_in

GO:0001172

transcription, RNA-templated

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003968

P

Seeded From UniProt

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005216

P

Seeded From UniProt

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0033897

P

Seeded From UniProt

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002166
InterPro:IPR036430

F

Seeded From UniProt

enables

GO:0003968

RNA-directed 5'-3' RNA polymerase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002166
InterPro:IPR007094
InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

enables

GO:0004175

endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030399

F

Seeded From UniProt

enables

GO:0004197

cysteine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000280
InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011492

F

Seeded From UniProt

enables

GO:0008026

ATP-dependent helicase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011492

F

Seeded From UniProt

involved_in

GO:0016032

viral process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008751

P

Seeded From UniProt

enables

GO:0016817

hydrolase activity, acting on acid anhydrides

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

enables

GO:0017111

nucleoside-triphosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

involved_in

GO:0019082

viral protein processing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008751

P

Seeded From UniProt

enables

GO:0033897

ribonuclease T2 activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR036430

F

Seeded From UniProt

involved_in

GO:0039694

viral RNA genome replication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002166
InterPro:IPR007094

P

Seeded From UniProt

enables

GO:0070008

serine-type exopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021824
InterPro:IPR022120

F

Seeded From UniProt

enables

GO:0017111

nucleoside-triphosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.6.1.15

F

Seeded From UniProt

enables

GO:0003968

RNA-directed 5'-3' RNA polymerase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.7.48

F

Seeded From UniProt

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

involved_in

GO:0039654

fusion of virus membrane with host endosome membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1170

P

Seeded From UniProt

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

part_of

GO:0030430

host cell cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1035
UniProtKB-SubCell:SL-0381

C

Seeded From UniProt

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

involved_in

GO:0051259

protein complex oligomerization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1182

P

Seeded From UniProt

part_of

GO:0033644

host cell membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1043
UniProtKB-SubCell:SL-0380

C

Seeded From UniProt

involved_in

GO:0039548

suppression by virus of host IRF3 activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1092

P

Seeded From UniProt

enables

GO:0016779

nucleotidyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0548

F

Seeded From UniProt

part_of

GO:0044385

integral to membrane of host cell

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1182

C

Seeded From UniProt

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

involved_in

GO:0030683

evasion or tolerance by virus of host immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0899

P

Seeded From UniProt

enables

GO:0003968

RNA-directed 5'-3' RNA polymerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0696

F

Seeded From UniProt

part_of

GO:0020002

host cell plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1032
UniProtKB-SubCell:SL-0375

C

Seeded From UniProt

involved_in

GO:0046718

viral entry into host cell

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1160
UniProtKB-KW:KW-1162

P

Seeded From UniProt

involved_in

GO:0039503

suppression by virus of host innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1090

P

Seeded From UniProt

enables

GO:0004386

helicase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0347

F

Seeded From UniProt

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

involved_in

GO:0039707

pore formation by virus in membrane of host cell

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1182

P

Seeded From UniProt

part_of

GO:0019012

virion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0946
UniProtKB-SubCell:SL-0274

C

Seeded From UniProt

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

involved_in

GO:0046718

viral entry into host cell

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1162

P

Seeded From UniProt

involved_in

GO:0039663

membrane fusion involved in viral entry into host cell

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1168

P

Seeded From UniProt

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

involved_in

GO:0019062

virion attachment to host cell

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1161

P

Seeded From UniProt

involved_in

GO:0039520

induction by virus of host autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1072

P

Seeded From UniProt

enables

GO:0005216

ion channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1182

F

Seeded From UniProt

part_of

GO:0055036

virion membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0275

C

Seeded From UniProt

part_of

GO:0020002

host cell plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0375

C

Seeded From UniProt

part_of

GO:0030430

host cell cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0381

C

Seeded From UniProt

part_of

GO:0033644

host cell membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0380

C

Seeded From UniProt

part_of

GO:0044228

host cell surface

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0378

C

Seeded From UniProt

part_of

GO:0019012

virion

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0274

C

Seeded From UniProt

involved_in

GO:0006508

proteolysis

PMID:24606708[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0008234

cysteine-type peptidase activity

PMID:24606708[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

involved_in

GO:0039548

suppression by virus of host IRF3 activity

PMID:17215286[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0030430

host cell cytoplasm

PMID:17215286[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:25809915[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q764M6

F

Seeded From UniProt

involved_in

GO:1901800

positive regulation of proteasomal protein catabolic process

PMID:25809915[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:1990214

negative regulation by symbiont of host protein levels

PMID:25809915[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039501

suppression by virus of host type I interferon production

PMID:25809915[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039548

suppression by virus of host IRF3 activity

PMID:19540847[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:19540847[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q764M6

F

Seeded From UniProt

involved_in

GO:0032688

negative regulation of interferon-beta production

PMID:19540847[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:17215286[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q764M6

F

Seeded From UniProt

involved_in

GO:1990214

negative regulation by symbiont of host protein levels

PMID:17215286[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:24965446[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60832,UniProtKB:P05455,UniProtKB:P08579,UniProtKB:P09211,UniProtKB:P11940,UniProtKB:P15880,UniProtKB:P18124,UniProtKB:P18621,UniProtKB:P19338,UniProtKB:P22626,UniProtKB:P26373,UniProtKB:P27635,UniProtKB:P31943,UniProtKB:P36578,UniProtKB:P38159,UniProtKB:P39019,UniProtKB:P39023,UniProtKB:P46782,UniProtKB:P61247,UniProtKB:P61254,UniProtKB:P61313,UniProtKB:P61978,UniProtKB:P62081,UniProtKB:P62244,UniProtKB:P62263,UniProtKB:P62277,UniProtKB:P62424,UniProtKB:P62750,UniProtKB:P62899,UniProtKB:P67809,UniProtKB:P83731,UniProtKB:P83881,UniProtKB:P84098,UniProtKB:Q00839,UniProtKB:Q08211,UniProtKB:Q12906,UniProtKB:Q53HK9,UniProtKB:Q59ES8,UniProtKB:Q59FI9,UniProtKB:Q59GL1,UniProtKB:Q5JR94,UniProtKB:Q8NC51,UniProtKB:Q9BU76,UniProtKB:Q9BVP2,UniProtKB:Q9Y3D9

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:24965446[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:B3KNR3,UniProtKB:B5BTY4,UniProtKB:C7DJS2,UniProtKB:F8W7C6,UniProtKB:O43143,UniProtKB:O76094,UniProtKB:P04844,UniProtKB:P05455,UniProtKB:P07910,UniProtKB:P11940,UniProtKB:P12956,UniProtKB:P17844,UniProtKB:P18077,UniProtKB:P22626,UniProtKB:P23396,UniProtKB:P26640,UniProtKB:P28161,UniProtKB:P37108,UniProtKB:P46778,UniProtKB:P46782,UniProtKB:P49458,UniProtKB:P52272,UniProtKB:P54577,UniProtKB:P61011,UniProtKB:P61247,UniProtKB:P62081,UniProtKB:P62266,UniProtKB:P62277,UniProtKB:P62701,UniProtKB:P62851,UniProtKB:P62913,UniProtKB:Q02543,UniProtKB:Q08211,UniProtKB:Q0VAC0,UniProtKB:Q12906,UniProtKB:Q13347,UniProtKB:Q13435,UniProtKB:Q53F35,UniProtKB:Q53GX7,UniProtKB:Q59GL1,UniProtKB:P52292,UniProtKB:Q8NC51,UniProtKB:Q92841,UniProtKB:Q92900,UniProtKB:Q96EY7,UniProtKB:Q99729,UniProtKB:Q9BUJ2,UniProtKB:Q9H6T3,UniProtKB:Q9NZI8,UniProtKB:Q9UHB9,UniProtKB:Q9Y262,UniProtKB:Q9Y285,UniProtKB:Q9Y5A9

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:24965446[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:B3KNR3,UniProtKB:B5BTY4,UniProtKB:C7DJS2,UniProtKB:P07910,UniProtKB:P11940,UniProtKB:P12956,UniProtKB:P14923,UniProtKB:P23396,UniProtKB:P28161,UniProtKB:P46782,UniProtKB:P52272,UniProtKB:P61011,UniProtKB:P61247,UniProtKB:P62081,UniProtKB:P62266,UniProtKB:P62701,UniProtKB:P62913,UniProtKB:Q02413,UniProtKB:Q08211,UniProtKB:Q0VAC0,UniProtKB:Q12906,UniProtKB:Q13435,UniProtKB:Q8NC51,UniProtKB:Q92841,UniProtKB:Q92900,UniProtKB:Q9NZI8,UniProtKB:Q9Y262

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:24965446[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q08211

F

Seeded From UniProt

involved_in

GO:1990219

positive regulation by symbiont of host protein levels

PMID:24965446[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:24965446[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P67809

F

Seeded From UniProt

part_of

GO:0030430

host cell cytoplasm

PMID:24965446[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0042025

host cell nucleus

PMID:24965446[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:1903608

protein localization to cytoplasmic stress granule

PMID:24965446[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:25809915[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q764M6

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:19540847[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q764M6

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:17215286[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q764M6

F

Seeded From UniProt

involved_in

GO:0039502

suppression by virus of host type I interferon-mediated signaling pathway

PMID:19767841[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039502

suppression by virus of host type I interferon-mediated signaling pathway

PMID:28290554[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0019013

viral nucleocapsid

PMID:1870198[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0010468

regulation of gene expression

PMID:9617770[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

PMID:8356450[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0004540

ribonuclease activity

PMID:8356450[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

involved_in

GO:0039707

pore formation by virus in membrane of host cell

PMID:24189547[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039547

suppression by virus of host TRAF activity

PMID:28751780[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0039644

suppression by virus of host NF-kappaB transcription factor activity

PMID:28751780[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

part_of

GO:0044165

host cell endoplasmic reticulum

PMID:26748656[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:26748656[13]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:F1S912

F

Seeded From UniProt

enables

GO:0005515

protein binding

PMID:25593157[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P19620

F

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Gottipati, K et al. (2014) Autocatalytic activity and substrate specificity of the pestivirus N-terminal protease Npro. Virology 452-453 303-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Bauhofer, O et al. (2007) Classical swine fever virus Npro interacts with interferon regulatory factor 3 and induces its proteasomal degradation. J. Virol. 81 3087-96 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Mine, J et al. (2015) The N-terminal domain of Npro of classical swine fever virus determines its stability and regulates type I IFN production. J. Gen. Virol. 96 1746-56 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Szymanski, MR et al. (2009) Zinc binding in pestivirus N(pro) is required for interferon regulatory factor 3 interaction and degradation. J. Mol. Biol. 391 438-49 PubMed GONUTS page
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 Jefferson, M et al. (2014) Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex. J. Virol. 88 10340-53 PubMed GONUTS page
  6. 6.0 6.1 Luo, X et al. (2009) Classical swine fever virus Erns glycoprotein antagonizes induction of interferon-beta by double-stranded RNA. Can. J. Microbiol. 55 698-704 PubMed GONUTS page
  7. 7.0 7.1 Riedel, C et al. (2017) The core protein of a pestivirus protects the incoming virus against IFN-induced effectors. Sci Rep 7 44459 PubMed GONUTS page
  8. 8.0 8.1 Thiel, HJ et al. (1991) Hog cholera virus: molecular composition of virions from a pestivirus. J. Virol. 65 4705-12 PubMed GONUTS page
  9. 9.0 9.1 Liu, JJ et al. (1998) The recombinant nucleocapsid protein of classical swine fever virus can act as a transcriptional regulator. Virus Res. 53 75-80 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Schneider, R et al. (1993) Identification of a structural glycoprotein of an RNA virus as a ribonuclease. Science 261 1169-71 PubMed GONUTS page
  11. 11.0 11.1 Largo, E et al. (2014) Pore-forming activity of pestivirus p7 in a minimal model system supports genus-specific viroporin function. Antiviral Res. 101 30-6 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Lv, H et al. (2017) TRAF6 is a novel NS3-interacting protein that inhibits classical swine fever virus replication. Sci Rep 7 6737 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 Li, H et al. (2016) FKBP8 interact with classical swine fever virus NS5A protein and promote virus RNA replication. Virus Genes 52 99-106 PubMed GONUTS page
  14. Sheng, C et al. (2015) Annexin A2 is involved in the production of classical swine fever virus infectious particles. J. Gen. Virol. 96 1027-32 PubMed GONUTS page