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CSFVA:POLG
Contents
Species (Taxon ID) | Classical swine fever virus (strain Alfort) (CSFV) (Hog choleravirus). (11097) | |
Gene Name(s) | No Information Provided. | |
Protein Name(s) | Genome polyprotein
N-terminal protease N-pro Autoprotease p20 Capsid protein C Core protein E(rns) glycoprotein gp44/48 Envelope glycoprotein E1 gp33 Envelope glycoprotein E2 gp55 p7 Non-structural protein 2-3 NS2-3 Cysteine protease NS2 Non-structural protein 2 Serine protease NS3 Non-structural protein 3 Non-structural protein 4A NS4A Non-structural protein 4B NS4B Non-structural protein 5A NS5A RNA-directed RNA polymerase NS5B | |
External Links | ||
UniProt | P19712 | |
EMBL | J04358 | |
PDB | 4CBG 4CBH 4CBI 4CBL 4CBM 5MZ4 | |
PDBsum | 4CBG 4CBH 4CBI 4CBL 4CBM 5MZ4 | |
ProteinModelPortal | P19712 | |
SMR | P19712 | |
IntAct | P19712 | |
MEROPS | C53.001 | |
PRIDE | P19712 | |
PMAP-CutDB | P19712 | |
Proteomes | UP000008568 | |
GO | GO:0030430 GO:0044165 GO:0042025 GO:0020002 GO:0044228 GO:0016021 GO:0044385 GO:0019013 GO:0055036 GO:0005524 GO:0008026 GO:0004197 GO:0008234 GO:0005216 GO:0004540 GO:0033897 GO:0003723 GO:0003968 GO:0004252 GO:0070008 GO:0039654 GO:0039520 GO:1990214 GO:0032688 GO:0039707 GO:1990219 GO:1901800 GO:0051259 GO:1903608 GO:0006508 GO:0010468 GO:0090501 GO:0039548 GO:0039644 GO:0039547 GO:0039501 GO:0039502 GO:0019082 GO:0039694 GO:0019062 | |
CDD | cd00079 | |
Gene3D | 3.90.730.10 | |
InterPro | IPR021824 IPR011492 IPR014001 IPR001650 IPR022120 IPR030399 IPR027417 IPR008751 IPR032521 IPR000280 IPR007094 IPR002166 IPR036430 IPR033130 | |
Pfam | PF11889 PF07652 PF00271 PF05550 PF12387 PF05578 PF16329 PF00998 | |
PRINTS | PR00729 | |
SMART | SM00487 SM00490 | |
SUPFAM | SSF52540 SSF55895 | |
PROSITE | PS51192 PS51194 PS51692 PS51535 PS51876 PS50507 PS00531 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
|||
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
|||
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
|||
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005216 |
P |
Seeded From UniProt |
|||
involved_in |
GO:0090502 |
RNA phosphodiester bond hydrolysis, endonucleolytic |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0033897 |
P |
Seeded From UniProt |
|||
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR002166 |
F |
Seeded From UniProt |
|||
enables |
GO:0004175 |
endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0004197 |
cysteine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0008026 |
ATP-dependent helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0016032 |
viral process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0016817 |
hydrolase activity, acting on acid anhydrides |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0017111 |
nucleoside-triphosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0019082 |
viral protein processing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0033897 |
ribonuclease T2 activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0039694 |
viral RNA genome replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0070008 |
serine-type exopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0017111 |
nucleoside-triphosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:1901800 |
positive regulation of proteasomal protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
|||
involved_in |
GO:1990214 |
negative regulation by symbiont of host protein levels |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
|||
involved_in |
GO:0039501 |
suppression by virus of host type I interferon production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
|||
involved_in |
GO:0032688 |
negative regulation of interferon-beta production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:1990214 |
negative regulation by symbiont of host protein levels |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
|||
involved_in |
GO:1990219 |
positive regulation by symbiont of host protein levels |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
|||
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:1903608 |
protein localization to cytoplasmic stress granule |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
part_of |
GO:0019013 |
viral nucleocapsid |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0090501 |
RNA phosphodiester bond hydrolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0004540 |
ribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0039707 |
pore formation by virus in membrane of host cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039547 |
suppression by virus of host TRAF activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039644 |
suppression by virus of host NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
part_of |
GO:0044165 |
host cell endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0039654 |
fusion of virus membrane with host endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0051259 |
protein complex oligomerization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0016779 |
nucleotidyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0044385 |
integral to membrane of host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0039707 |
pore formation by virus in membrane of host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039663 |
membrane fusion involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0019062 |
virion attachment to host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039520 |
induction by virus of host autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0005216 |
ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0055036 |
virion membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
part_of |
GO:0044228 |
host cell surface |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
|
Seeded From UniProt |
|||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
|
Seeded From UniProt |
|||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
|
Seeded From UniProt |
|||
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
|||
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
|||
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
|||
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005216 |
P |
Seeded From UniProt |
|||
involved_in |
GO:0090502 |
RNA phosphodiester bond hydrolysis, endonucleolytic |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0033897 |
P |
Seeded From UniProt |
|||
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR002166 |
F |
Seeded From UniProt |
|||
enables |
GO:0004175 |
endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0004197 |
cysteine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0008026 |
ATP-dependent helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0016032 |
viral process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0016817 |
hydrolase activity, acting on acid anhydrides |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0017111 |
nucleoside-triphosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0019082 |
viral protein processing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0033897 |
ribonuclease T2 activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0039694 |
viral RNA genome replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0070008 |
serine-type exopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0017111 |
nucleoside-triphosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0039654 |
fusion of virus membrane with host endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0051259 |
protein complex oligomerization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0016779 |
nucleotidyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0044385 |
integral to membrane of host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0039707 |
pore formation by virus in membrane of host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039663 |
membrane fusion involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0019062 |
virion attachment to host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039520 |
induction by virus of host autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0005216 |
ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0055036 |
virion membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
part_of |
GO:0044228 |
host cell surface |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:1901800 |
positive regulation of proteasomal protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
|||
involved_in |
GO:1990214 |
negative regulation by symbiont of host protein levels |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
|||
involved_in |
GO:0039501 |
suppression by virus of host type I interferon production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
|||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0032688 |
negative regulation of interferon-beta production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:1990214 |
negative regulation by symbiont of host protein levels |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
|||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:O60832,UniProtKB:P05455,UniProtKB:P08579,UniProtKB:P09211,UniProtKB:P11940,UniProtKB:P15880,UniProtKB:P18124,UniProtKB:P18621,UniProtKB:P19338,UniProtKB:P22626,UniProtKB:P26373,UniProtKB:P27635,UniProtKB:P31943,UniProtKB:P36578,UniProtKB:P38159,UniProtKB:P39019,UniProtKB:P39023,UniProtKB:P46782,UniProtKB:P61247,UniProtKB:P61254,UniProtKB:P61313,UniProtKB:P61978,UniProtKB:P62081,UniProtKB:P62244,UniProtKB:P62263,UniProtKB:P62277,UniProtKB:P62424,UniProtKB:P62750,UniProtKB:P62899,UniProtKB:P67809,UniProtKB:P83731,UniProtKB:P83881,UniProtKB:P84098,UniProtKB:Q00839,UniProtKB:Q08211,UniProtKB:Q12906,UniProtKB:Q53HK9,UniProtKB:Q59ES8,UniProtKB:Q59FI9,UniProtKB:Q59GL1,UniProtKB:Q5JR94,UniProtKB:Q8NC51,UniProtKB:Q9BU76,UniProtKB:Q9BVP2,UniProtKB:Q9Y3D9 |
F |
Seeded From UniProt |
|||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:B3KNR3,UniProtKB:B5BTY4,UniProtKB:C7DJS2,UniProtKB:F8W7C6,UniProtKB:O43143,UniProtKB:O76094,UniProtKB:P04844,UniProtKB:P05455,UniProtKB:P07910,UniProtKB:P11940,UniProtKB:P12956,UniProtKB:P17844,UniProtKB:P18077,UniProtKB:P22626,UniProtKB:P23396,UniProtKB:P26640,UniProtKB:P28161,UniProtKB:P37108,UniProtKB:P46778,UniProtKB:P46782,UniProtKB:P49458,UniProtKB:P52272,UniProtKB:P54577,UniProtKB:P61011,UniProtKB:P61247,UniProtKB:P62081,UniProtKB:P62266,UniProtKB:P62277,UniProtKB:P62701,UniProtKB:P62851,UniProtKB:P62913,UniProtKB:Q02543,UniProtKB:Q08211,UniProtKB:Q0VAC0,UniProtKB:Q12906,UniProtKB:Q13347,UniProtKB:Q13435,UniProtKB:Q53F35,UniProtKB:Q53GX7,UniProtKB:Q59GL1,UniProtKB:P52292,UniProtKB:Q8NC51,UniProtKB:Q92841,UniProtKB:Q92900,UniProtKB:Q96EY7,UniProtKB:Q99729,UniProtKB:Q9BUJ2,UniProtKB:Q9H6T3,UniProtKB:Q9NZI8,UniProtKB:Q9UHB9,UniProtKB:Q9Y262,UniProtKB:Q9Y285,UniProtKB:Q9Y5A9 |
F |
Seeded From UniProt |
|||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:B3KNR3,UniProtKB:B5BTY4,UniProtKB:C7DJS2,UniProtKB:P07910,UniProtKB:P11940,UniProtKB:P12956,UniProtKB:P14923,UniProtKB:P23396,UniProtKB:P28161,UniProtKB:P46782,UniProtKB:P52272,UniProtKB:P61011,UniProtKB:P61247,UniProtKB:P62081,UniProtKB:P62266,UniProtKB:P62701,UniProtKB:P62913,UniProtKB:Q02413,UniProtKB:Q08211,UniProtKB:Q0VAC0,UniProtKB:Q12906,UniProtKB:Q13435,UniProtKB:Q8NC51,UniProtKB:Q92841,UniProtKB:Q92900,UniProtKB:Q9NZI8,UniProtKB:Q9Y262 |
F |
Seeded From UniProt |
|||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:1990219 |
positive regulation by symbiont of host protein levels |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
|||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:1903608 |
protein localization to cytoplasmic stress granule |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
part_of |
GO:0019013 |
viral nucleocapsid |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0090501 |
RNA phosphodiester bond hydrolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
enables |
GO:0004540 |
ribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
||||
involved_in |
GO:0039707 |
pore formation by virus in membrane of host cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039547 |
suppression by virus of host TRAF activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
involved_in |
GO:0039644 |
suppression by virus of host NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
part_of |
GO:0044165 |
host cell endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
| |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gottipati, K et al. (2014) Autocatalytic activity and substrate specificity of the pestivirus N-terminal protease Npro. Virology 452-453 303-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Bauhofer, O et al. (2007) Classical swine fever virus Npro interacts with interferon regulatory factor 3 and induces its proteasomal degradation. J. Virol. 81 3087-96 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Mine, J et al. (2015) The N-terminal domain of Npro of classical swine fever virus determines its stability and regulates type I IFN production. J. Gen. Virol. 96 1746-56 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Szymanski, MR et al. (2009) Zinc binding in pestivirus N(pro) is required for interferon regulatory factor 3 interaction and degradation. J. Mol. Biol. 391 438-49 PubMed GONUTS page
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 Jefferson, M et al. (2014) Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex. J. Virol. 88 10340-53 PubMed GONUTS page
- ↑ 6.0 6.1 Luo, X et al. (2009) Classical swine fever virus Erns glycoprotein antagonizes induction of interferon-beta by double-stranded RNA. Can. J. Microbiol. 55 698-704 PubMed GONUTS page
- ↑ 7.0 7.1 Riedel, C et al. (2017) The core protein of a pestivirus protects the incoming virus against IFN-induced effectors. Sci Rep 7 44459 PubMed GONUTS page
- ↑ 8.0 8.1 Thiel, HJ et al. (1991) Hog cholera virus: molecular composition of virions from a pestivirus. J. Virol. 65 4705-12 PubMed GONUTS page
- ↑ 9.0 9.1 Liu, JJ et al. (1998) The recombinant nucleocapsid protein of classical swine fever virus can act as a transcriptional regulator. Virus Res. 53 75-80 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Schneider, R et al. (1993) Identification of a structural glycoprotein of an RNA virus as a ribonuclease. Science 261 1169-71 PubMed GONUTS page
- ↑ 11.0 11.1 Largo, E et al. (2014) Pore-forming activity of pestivirus p7 in a minimal model system supports genus-specific viroporin function. Antiviral Res. 101 30-6 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 Lv, H et al. (2017) TRAF6 is a novel NS3-interacting protein that inhibits classical swine fever virus replication. Sci Rep 7 6737 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Li, H et al. (2016) FKBP8 interact with classical swine fever virus NS5A protein and promote virus RNA replication. Virus Genes 52 99-106 PubMed GONUTS page
- ↑ Sheng, C et al. (2015) Annexin A2 is involved in the production of classical swine fever virus infectious particles. J. Gen. Virol. 96 1027-32 PubMed GONUTS page
c
h
- GO:0004386 ! helicase activity
- GO:0030430 ! host cell cytoplasm
- GO:0044165 ! host cell endoplasmic reticulum
- GO:0033644 ! host cell membrane
- GO:0042025 ! host cell nucleus
- GO:0020002 ! host cell plasma membrane
- GO:0044228 ! host cell surface
- GO:0016787 ! hydrolase activity
- GO:0016817 ! hydrolase activity, acting on acid anhydrides
m
n
o
- GO:0044385 ! obsolete integral to membrane of host cell
- GO:1990214 ! obsolete negative regulation by symbiont of host protein levels
- GO:1990219 ! obsolete positive regulation by symbiont of host protein levels
- GO:0090502 ! obsolete RNA phosphodiester bond hydrolysis, endonucleolytic
- GO:0090501 ! obsolete RNA phosphodiester bond hydrolysis
- GO:0039503 ! obsolete suppression by virus of host innate immune response
- GO:0039644 ! obsolete suppression by virus of host NF-kappaB cascade
- GO:0039707 ! obsolete virus-mediated pore formation in host cell membrane
p
r
s
- GO:0070008 ! serine-type exopeptidase activity
- GO:0004252 ! serine-type endopeptidase activity
- GO:0008236 ! serine-type peptidase activity
- ssRNA positive-strand viruses, no DNA stage
- ssRNA viruses
- GO:0039547 ! suppression by virus of host TRAF activity
- GO:0039501 ! suppression by virus of host type I interferon production
- GO:0039502 ! symbiont-mediated suppression of host type I interferon-mediated signaling pathway
- GO:0039548 ! symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
- GO:0046718 ! symbiont entry into host cell