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CHICK:VEGFA

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) VEGFA (synonyms: VEGF)
Protein Name(s) Vascular endothelial growth factor A

VEGF-A Vascular permeability factor VPF

External Links
UniProt P67964
EMBL AB011078
RefSeq NP_001103825.1
NP_990373.1
UniGene Gga.537
ProteinModelPortal P67964
SMR P67964
GeneID 395909
KEGG gga:395909
CTD 7422
eggNOG NOG73329
HOGENOM HOG000230896
HOVERGEN HBG000105
InParanoid P67964
KO K05448
PhylomeDB P67964
Reactome REACT_197104
REACT_238231
REACT_244390
REACT_250039
REACT_250385
REACT_253932
NextBio 20815974
PRO PR:P67964
Proteomes UP000000539
ExpressionAtlas P67964
GO GO:0009986
GO:0005615
GO:0016020
GO:0030141
GO:0042056
GO:0050840
GO:0008201
GO:0032147
GO:0002575
GO:0001955
GO:0048593
GO:0048739
GO:0060948
GO:0048469
GO:0002042
GO:0008283
GO:0071679
GO:0060982
GO:0003169
GO:0071542
GO:0035767
GO:0003347
GO:0030855
GO:0042462
GO:0040007
GO:0001822
GO:0060426
GO:0036303
GO:0030225
GO:0007498
GO:0030224
GO:0043154
GO:2001237
GO:0043524
GO:0000122
GO:0003151
GO:0001541
GO:0001569
GO:0045766
GO:0048842
GO:0090190
GO:0051781
GO:0090050
GO:0038091
GO:0032793
GO:0038033
GO:0001938
GO:0070374
GO:0051894
GO:1901727
GO:1901492
GO:0043406
GO:0060754
GO:0002053
GO:0002052
GO:1900745
GO:0033138
GO:1900086
GO:0050731
GO:0050927
GO:0031334
GO:0051897
GO:0090037
GO:1902966
GO:0002092
GO:1902336
GO:0061419
GO:0030949
GO:0043117
GO:0031077
GO:0060319
GO:0008360
GO:0043129
GO:0035148
GO:0038190
Gene3D 2.10.160.10
2.10.90.10
InterPro IPR029034
IPR023581
IPR000072
IPR027928
Pfam PF00341
PF14554
SMART SM00141
SUPFAM SSF57501
SSF57593
PROSITE PS00249
PS50278

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045766

positive regulation of angiogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P67965-4

P

Seeded From UniProt

complete

involved_in

GO:0043117

positive regulation of vascular permeability

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P67965-4

P

Seeded From UniProt

complete

involved_in

GO:0001955

blood vessel maturation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P67965-4

P

Seeded From UniProt

complete

involved_in

GO:0051894

positive regulation of focal adhesion assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15692

P

Seeded From UniProt

complete

involved_in

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15692

P

Seeded From UniProt

complete

involved_in

GO:0031334

positive regulation of protein complex assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15692

P

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15692

P

Seeded From UniProt

complete

involved_in

GO:0060754

positive regulation of mast cell chemotaxis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246442
UniProtKB:O43915
UniProtKB:P15692
UniProtKB:P49765
UniProtKB:P49767

P

Seeded From UniProt

complete

involved_in

GO:0050930

induction of positive chemotaxis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246442
UniProtKB:O43915
UniProtKB:P15692
UniProtKB:P49765
UniProtKB:P49767

P

Seeded From UniProt

complete

involved_in

GO:0048010

vascular endothelial growth factor receptor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
MGI:MGI:108037
MGI:MGI:109124
PANTHER:PTN000246442
RGD:619991
RGD:620695
UniProtKB:P15692
UniProtKB:P49767
ZFIN:ZDB-GENE-990415-273

P

Seeded From UniProt

complete

involved_in

GO:0045766

positive regulation of angiogenesis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
MGI:MGI:109124
PANTHER:PTN000246442
RGD:619850
RGD:619991
UniProtKB:P15692

P

Seeded From UniProt

complete

enables

GO:0043183

vascular endothelial growth factor receptor 1 binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
PANTHER:PTN002635039
UniProtKB:P15692
UniProtKB:P49765

F

Seeded From UniProt

complete

enables

GO:0042056

chemoattractant activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
PANTHER:PTN000246442
RGD:619991
UniProtKB:O43915
UniProtKB:P15692
UniProtKB:P49765
UniProtKB:P49767

F

Seeded From UniProt

complete

involved_in

GO:0038084

vascular endothelial growth factor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
PANTHER:PTN000246442
UniProtKB:P15692
ZFIN:ZDB-GENE-040303-4

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
MGI:MGI:108037
PANTHER:PTN000246442
RGD:619991
UniProtKB:P15691
UniProtKB:P15692
UniProtKB:P49763

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
MGI:MGI:105095
MGI:MGI:108037
MGI:MGI:109124
PANTHER:PTN000246442
RGD:619850
RGD:619991
UniProtKB:P15691
UniProtKB:P15692
UniProtKB:P49765

C

Seeded From UniProt

complete

enables

GO:0005172

vascular endothelial growth factor receptor binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
MGI:MGI:108037
MGI:MGI:109124
PANTHER:PTN000246442
RGD:619800
RGD:619991
RGD:620695
UniProtKB:O43915
UniProtKB:P15692
UniProtKB:P49765
UniProtKB:P49767
ZFIN:ZDB-GENE-040303-4

F

Seeded From UniProt

complete

involved_in

GO:0002040

sprouting angiogenesis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
PANTHER:PTN000246442
RGD:619850
ZFIN:ZDB-GENE-030131-4605
ZFIN:ZDB-GENE-040303-4

P

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
PANTHER:PTN000246442
RGD:619850
UniProtKB:P15691
UniProtKB:P15692
UniProtKB:P49765

P

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246442
UniProtKB:P15692

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246442
RGD:619850
RGD:619991
RGD:620695
UniProtKB:P15692

P

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103178
PANTHER:PTN000246442
RGD:619799
RGD:619800
RGD:619991
UniProtKB:P15692
ZFIN:ZDB-GENE-070810-6

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0050918

positive chemotaxis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0042056

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000072

F

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027928
InterPro:IPR036841

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000072

C

Seeded From UniProt

complete

involved_in

GO:0003347

epicardial cell to mesenchymal cell transition

PMID:20299672[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0037

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

involved_in

GO:0051781

positive regulation of cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0497

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page