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CHICK:TOP2B

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) TOP2B
Protein Name(s) DNA topoisomerase 2-beta

DNA topoisomerase II, beta isozyme

External Links
UniProt O42131
EMBL AB007446
RefSeq NP_990413.1
UniGene Gga.30963
ProteinModelPortal O42131
SMR O42131
STRING 9031.ENSGALP00000018410
PaxDb O42131
PRIDE O42131
GeneID 395966
KEGG gga:395966
CTD 7155
eggNOG COG0187
HOGENOM HOG000216693
HOVERGEN HBG052998
InParanoid O42131
KO K03164
PhylomeDB O42131
NextBio 20816031
PRO PR:O42131
Proteomes UP000000539
GO GO:0005654
GO:0005524
GO:0008301
GO:0003918
GO:0046872
GO:0006200
GO:0006265
Gene3D 1.10.268.10
3.30.1360.40
3.30.230.10
3.30.565.10
3.40.50.670
3.90.199.10
InterPro IPR024946
IPR012542
IPR003594
IPR020568
IPR014721
IPR028467
IPR001241
IPR002205
IPR013758
IPR013757
IPR013506
IPR013759
IPR013760
IPR018522
IPR006171
PANTHER PTHR10169:SF36
Pfam PF00204
PF00521
PF08070
PF02518
PF01751
PRINTS PR00418
SMART SM00387
SM00433
SM00434
SUPFAM SSF54211
SSF55874
SSF56719
PROSITE PS00177
PS50880

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005634

nucleus

PMID:11453553[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

NOT|part_of

GO:0000792

heterochromatin

PMID:11453553[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14TE9

C

Seeded From UniProt

complete

enables

GO:0003916

DNA topoisomerase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14TE9

F

Seeded From UniProt

complete

involved_in

GO:0006265

DNA topological change

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q02880

P

Seeded From UniProt

complete

enables

GO:0003918

DNA topoisomerase type II (ATP-hydrolyzing) activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q02880

F

Seeded From UniProt

complete

involved_in

GO:0044774

mitotic DNA integrity checkpoint

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000018888
SGD:S000005032

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003732
MGI:MGI:98790
MGI:MGI:98791
PANTHER:PTN000018888
PomBase:SPBC1A4.03c
RGD:62048
SGD:S000005032
UniProtKB:O42130
UniProtKB:O42131
UniProtKB:P11388
UniProtKB:P30182
UniProtKB:Q02880
UniProtKB:Q5B224
dictyBase:DDB_G0279737

C

Seeded From UniProt

complete

involved_in

GO:0000819

sister chromatid segregation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003732
PANTHER:PTN000018888

P

Seeded From UniProt

complete

involved_in

GO:0000712

resolution of meiotic recombination intermediates

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000018888
PomBase:SPBC1A4.03c

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001154
InterPro:IPR001241
InterPro:IPR002205
InterPro:IPR013506
InterPro:IPR013757
InterPro:IPR013758
InterPro:IPR013759
InterPro:IPR018522

F

Seeded From UniProt

complete

enables

GO:0003918

DNA topoisomerase type II (ATP-hydrolyzing) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001154
InterPro:IPR001241
InterPro:IPR002205
InterPro:IPR013506
InterPro:IPR013757
InterPro:IPR013758
InterPro:IPR013759
InterPro:IPR013760
InterPro:IPR018522

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001154
InterPro:IPR001241
InterPro:IPR002205
InterPro:IPR013506
InterPro:IPR013757
InterPro:IPR013758
InterPro:IPR013759
InterPro:IPR013760
InterPro:IPR018522

F

Seeded From UniProt

complete

involved_in

GO:0006259

DNA metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013758

P

Seeded From UniProt

complete

involved_in

GO:0006265

DNA topological change

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001154
InterPro:IPR001241
InterPro:IPR002205
InterPro:IPR013506
InterPro:IPR013758
InterPro:IPR013759
InterPro:IPR018522

P

Seeded From UniProt

complete

enables

GO:0003918

DNA topoisomerase type II (ATP-hydrolyzing) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.99.1.3

F

Seeded From UniProt

complete

enables

GO:0061505

DNA topoisomerase II activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.99.1.3

F

Seeded From UniProt

complete

enables

GO:0003916

DNA topoisomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0799

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Niimi, A et al. (2001) Co-localization of chicken DNA topoisomerase IIalpha, but not beta, with sites of DNA replication and possible involvement of a C-terminal region of alpha through its binding to PCNA. Chromosoma 110 102-14 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page