CHICK:TOP2A

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	TOP2A
Protein Name(s)	DNA topoisomerase 2-alpha DNA topoisomerase II, alpha isozyme
External Links
UniProt	O42130
EMBL	AB007445
RefSeq	NP_990122.1
UniGene	Gga.2010
ProteinModelPortal	O42130
SMR	O42130
STRING	9031.ENSGALP00000006239
PaxDb	O42130
GeneID	395570
KEGG	gga:395570
CTD	7153
eggNOG	COG0187
HOGENOM	HOG000216693
HOVERGEN	HBG052998
InParanoid	O42130
KO	K03164
PhylomeDB	O42130
NextBio	20815644
PRO	PR:O42130
Proteomes	UP000000539
GO	GO:0009330 GO:0005654 GO:0005634 GO:0005524 GO:0003677 GO:0008301 GO:0003918 GO:0008094 GO:0008144 GO:0000287 GO:0030263 GO:0006200 GO:0006974 GO:0007059 GO:0006266 GO:0006265 GO:0043065
Gene3D	1.10.268.10 3.30.1360.40 3.30.230.10 3.30.565.10 3.40.50.670 3.90.199.10
InterPro	IPR024946 IPR012542 IPR003594 IPR020568 IPR014721 IPR028466 IPR001241 IPR002205 IPR013758 IPR013757 IPR013506 IPR013759 IPR013760 IPR018522 IPR006171
PANTHER	PTHR10169:SF33
Pfam	PF00204 PF00521 PF08070 PF02518 PF01751
PRINTS	PR00418
SMART	SM00387 SM00433 SM00434
SUPFAM	SSF54211 SSF55874 SSF56719
PROSITE	PS00177 PS50880

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0008283	cell population proliferation	PMID:3025219^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	PMID:3025219^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	PMID:3025219^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:2985625^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	PMID:2985625^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:11453553^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9DEA3	F	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	PMID:11453553^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:11453553^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:11453553^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	C	Seeded From UniProt	complete
involved_in	GO:1905463	negative regulation of DNA duplex unwinding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	P	Seeded From UniProt	complete
involved_in	GO:0030263	apoptotic chromosome condensation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	P	Seeded From UniProt	complete
part_of	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	C	Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	F	Seeded From UniProt	complete
enables	GO:0008094	DNA-dependent ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	F	Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	P	Seeded From UniProt	complete
involved_in	GO:0006266	DNA ligation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	C	Seeded From UniProt	complete
enables	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	F	Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	F	Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	P	Seeded From UniProt	complete
enables	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	F	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11388	F	Seeded From UniProt	complete
involved_in	GO:0044774	mitotic DNA integrity checkpoint	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000018888 SGD:S000005032	P	Seeded From UniProt	complete
involved_in	GO:0030263	apoptotic chromosome condensation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000018897 UniProtKB:P11388	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003732 MGI:MGI:98790 MGI:MGI:98791 PANTHER:PTN000018888 PomBase:SPBC1A4.03c RGD:62048 SGD:S000005032 UniProtKB:O42130 UniProtKB:O42131 UniProtKB:P11388 UniProtKB:P30182 UniProtKB:Q02880 UniProtKB:Q5B224 dictyBase:DDB_G0279737	C	Seeded From UniProt	complete
involved_in	GO:0000819	sister chromatid segregation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003732 PANTHER:PTN000018888	P	Seeded From UniProt	complete
involved_in	GO:0000712	resolution of meiotic recombination intermediates	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000018888 PomBase:SPBC1A4.03c	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001154 InterPro:IPR001241 InterPro:IPR002205 InterPro:IPR013506 InterPro:IPR013757 InterPro:IPR013758 InterPro:IPR013759 InterPro:IPR018522	F	Seeded From UniProt	complete
enables	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001154 InterPro:IPR001241 InterPro:IPR002205 InterPro:IPR013506 InterPro:IPR013757 InterPro:IPR013758 InterPro:IPR013759 InterPro:IPR013760 InterPro:IPR018522	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001154 InterPro:IPR001241 InterPro:IPR002205 InterPro:IPR013506 InterPro:IPR013757 InterPro:IPR013758 InterPro:IPR013759 InterPro:IPR013760 InterPro:IPR018522	F	Seeded From UniProt	complete
involved_in	GO:0006259	DNA metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013758	P	Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001154 InterPro:IPR001241 InterPro:IPR002205 InterPro:IPR013506 InterPro:IPR013758 InterPro:IPR013759 InterPro:IPR018522	P	Seeded From UniProt	complete
enables	GO:0061505	DNA topoisomerase II activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.99.1.3	F	Seeded From UniProt	complete
enables	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.99.1.3	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0003916	DNA topoisomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0799	F	Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Heck, MM & Earnshaw, WC (1986) Topoisomerase II: A specific marker for cell proliferation. J. Cell Biol. 103 2569-81 PubMed GONUTS page
↑ ^2.0 ^2.1 Earnshaw, WC et al. (1985) Topoisomerase II is a structural component of mitotic chromosome scaffolds. J. Cell Biol. 100 1706-15 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Niimi, A et al. (2001) Co-localization of chicken DNA topoisomerase IIalpha, but not beta, with sites of DNA replication and possible involvement of a C-terminal region of alpha through its binding to PCNA. Chromosoma 110 102-14 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:3025219-1] 1.0 ^1.1 ^1.2 Heck, MM & Earnshaw, WC (1986) Topoisomerase II: A specific marker for cell proliferation. J. Cell Biol. 103 2569-81 PubMed GONUTS page

[PMID:2985625-2] 2.0 ^2.1 Earnshaw, WC et al. (1985) Topoisomerase II is a structural component of mitotic chromosome scaffolds. J. Cell Biol. 100 1706-15 PubMed GONUTS page

[PMID:11453553-3] 3.0 ^3.1 ^3.2 ^3.3 Niimi, A et al. (2001) Co-localization of chicken DNA topoisomerase IIalpha, but not beta, with sites of DNA replication and possible involvement of a C-terminal region of alpha through its binding to PCNA. Chromosoma 110 102-14 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:TOP2A

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