CHICK:SOX2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	SOX2
Protein Name(s)	Transcription factor SOX-2 cSox2 delta EF2a
External Links
UniProt	P48430
EMBL	U12532 D50603 AB092842
PIR	I50706
RefSeq	NP_990519.1
UniGene	Gga.601
ProteinModelPortal	P48430
SMR	P48430
Ensembl	ENSGALT00000014379
GeneID	396105
KEGG	gga:396105
CTD	6657
GeneTree	ENSGT00760000118988
HOGENOM	HOG000231647
HOVERGEN	HBG105663
InParanoid	P48430
KO	K16796
OMA	MSALQYN
OrthoDB	EOG7TMZVP
PhylomeDB	P48430
TreeFam	TF351735
Reactome	REACT_236930 REACT_258678
NextBio	20816163
PRO	PR:P48430
Proteomes	UP000000539
GO	GO:0005829 GO:0044798 GO:0005634 GO:0003682 GO:0035198 GO:0043565 GO:0000981 GO:0044212 GO:0021984 GO:0007050 GO:0021987 GO:0050973 GO:0050910 GO:0048852 GO:0001714 GO:0060441 GO:0021879 GO:0042472 GO:0060235 GO:0048286 GO:0030539 GO:0090090 GO:0050680 GO:0045665 GO:0045668 GO:0000122 GO:0048663 GO:0030910 GO:0001649 GO:0046148 GO:0030858 GO:0043410 GO:0002052 GO:0045666 GO:0045747 GO:0045944 GO:0045893 GO:0043281 GO:0070848 GO:0032526 GO:0009611 GO:0060042 GO:0035019 GO:0043586
Gene3D	1.10.30.10
InterPro	IPR009071 IPR022097
Pfam	PF00505 PF12336
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0016360	sensory organ precursor cell fate determination	PMID:23071561^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(UBERON:0001846)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:23071561^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001846)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17534940^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0003051)\|part_of:(UBERON:0013731)\|part_of:(UBERON:0007275)\|part_of:(UBERON:0007276)\|part_of:(UBERON:0002214)\|part_of:(UBERON:0002212)\|part_of:(CL:0002374)\|part_of:(CL:0002573) part_of:(UBERON:0001648)\|part_of:(UBERON:0003053) part_of:(UBERON:0002028)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:20071511^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0005014)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22973454^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001795)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7628452^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:7628452^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	PMID:14517545^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:7628452^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030807 UniProtKB:P48431	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98364 PANTHER:PTN000030807 RGD:1565646 UniProtKB:P48430 UniProtKB:P48431	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98364 PANTHER:PTN000030807	P		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98362 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98660 PANTHER:PTN000030384	C		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030807 UniProtKB:P48431	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030745 ZFIN:ZDB-GENE-980526-333	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98363 PANTHER:PTN000030384	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030745 ZFIN:ZDB-GENE-980526-333	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:2654070 MGI:MGI:98364 PANTHER:PTN000030384 UniProtKB:P48431 UniProtKB:Q06945	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000411 FB:FBgn0005612 FB:FBgn0005613 FB:FBgn0029123 FB:FBgn0036411 MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98357 MGI:MGI:98359 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98369 MGI:MGI:98660 PANTHER:PTN000030384 RGD:1565646 RGD:3759 RGD:69351 UniProtKB:P35713 UniProtKB:P35716 UniProtKB:P48430 UniProtKB:P48431 UniProtKB:Q05066 UniProtKB:Q06945 UniProtKB:Q9BT81 UniProtKB:Q9H6I2 WB:WBGene00004771	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98362 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98660 PANTHER:PTN000030384 ZFIN:ZDB-GENE-990715-6	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98364 PANTHER:PTN000030807	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7628452^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0070848	response to growth factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	F		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	F		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0021983	pituitary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	F		Seeded From UniProt	complete
involved_in	GO:0001714	endodermal cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48431 ensembl:ENSP00000323588	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0U3FYV6 ensembl:ENSP00000323588	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032643	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032643	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022097 InterPro:IPR032643	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Freeman, SD & Daudet, N (2012) Artificial induction of Sox21 regulates sensory cell formation in the embryonic chicken inner ear. PLoS ONE 7 e46387 PubMed GONUTS page
↑ Neves, J et al. (2007) Differential expression of Sox2 and Sox3 in neuronal and sensory progenitors of the developing inner ear of the chick. J. Comp. Neurol. 503 487-500 PubMed GONUTS page
↑ McCullar, JS et al. (2010) Activin potentiates proliferation in mature avian auditory sensory epithelium. J. Neurosci. 30 478-90 PubMed GONUTS page
↑ Zelinka, CP et al. (2012) The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1. PLoS ONE 7 e44477 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kamachi, Y et al. (1995) Involvement of SOX proteins in lens-specific activation of crystallin genes. EMBO J. 14 3510-9 PubMed GONUTS page
↑ Bylund, M et al. (2003) Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat. Neurosci. 6 1162-8 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23071561-1] 1.0 ^1.1 Freeman, SD & Daudet, N (2012) Artificial induction of Sox21 regulates sensory cell formation in the embryonic chicken inner ear. PLoS ONE 7 e46387 PubMed GONUTS page

[PMID:17534940-2] Neves, J et al. (2007) Differential expression of Sox2 and Sox3 in neuronal and sensory progenitors of the developing inner ear of the chick. J. Comp. Neurol. 503 487-500 PubMed GONUTS page

[PMID:20071511-3] McCullar, JS et al. (2010) Activin potentiates proliferation in mature avian auditory sensory epithelium. J. Neurosci. 30 478-90 PubMed GONUTS page

[PMID:22973454-4] Zelinka, CP et al. (2012) The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1. PLoS ONE 7 e44477 PubMed GONUTS page

[PMID:7628452-5] 5.0 ^5.1 ^5.2 ^5.3 Kamachi, Y et al. (1995) Involvement of SOX proteins in lens-specific activation of crystallin genes. EMBO J. 14 3510-9 PubMed GONUTS page

[PMID:14517545-6] Bylund, M et al. (2003) Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat. Neurosci. 6 1162-8 PubMed GONUTS page

[PMID:21873635-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:SOX2

Contents

Annotations

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References

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