GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
CHICK:SMAD6
Contents
| Species (Taxon ID) | Gallus gallus (Chicken). (9031) | |
| Gene Name(s) | SMAD6 (synonyms: MADH6) | |
| Protein Name(s) | Mothers against decapentaplegic homolog 6
MAD homolog 6 Mothers against DPP homolog 6 SMAD family member 6 SMAD 6 Smad6 | |
| External Links | ||
| UniProt | Q9W734 | |
| EMBL | AF165889 | |
| RefSeq | NP_989579.1 | |
| UniGene | Gga.3878 | |
| ProteinModelPortal | Q9W734 | |
| PRIDE | Q9W734 | |
| GeneID | 374096 | |
| KEGG | gga:374096 | |
| CTD | 4091 | |
| HOVERGEN | HBG053021 | |
| InParanoid | Q9W734 | |
| KO | K04677 | |
| PhylomeDB | Q9W734 | |
| Reactome | REACT_251716 | |
| NextBio | 20813615 | |
| PRO | PR:Q9W734 | |
| Proteomes | UP000000539 | |
| ExpressionAtlas | Q9W734 | |
| GO | GO:0005634 GO:0005667 GO:0003682 GO:0046872 GO:0003700 GO:0044212 GO:0030617 GO:0030509 GO:0031589 GO:0045444 GO:0006955 GO:0043066 GO:0030514 GO:0008285 GO:0060394 GO:0010991 GO:0030512 GO:0034616 GO:0006351 GO:0007179 GO:0001657 GO:0007352 | |
| Gene3D | 2.60.200.10 3.90.520.10 | |
| InterPro | IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984 | |
| PANTHER | PTHR13703 | |
| Pfam | PF03165 PF03166 | |
| SMART | SM00523 SM00524 | |
| SUPFAM | SSF49879 SSF56366 | |
| PROSITE | PS51075 PS51076 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1902844 |
positive regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902832 |
negative regulation of cell proliferation in dorsal spinal cord |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050767 |
regulation of neurogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0002256) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032331 |
negative regulation of chondrocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010693 |
negative regulation of alkaline phosphatase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0011004) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031589 |
cell-substrate adhesion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001132 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Xie, Z et al. (2011) Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/beta-catenin pathway. Proc. Natl. Acad. Sci. U.S.A. 108 12119-24 PubMed GONUTS page
- ↑ 2.0 2.1 Li, X et al. (2003) Smad6 is induced by BMP-2 and modulates chondrocyte differentiation. J. Orthop. Res. 21 908-13 PubMed GONUTS page
- ↑ 3.0 3.1 Rajagopal, R et al. (2007) Intracellular mediators of transforming growth factor beta superfamily signaling localize to endosomes in chicken embryo and mouse lenses in vivo. BMC Cell Biol. 8 25 PubMed GONUTS page
c
n
t
