CHICK:Q91000

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	FURIN (ECO:0000313 with Ensembl:ENSGALP00000013566)
Protein Name(s)	Trans Golgi network protease furin (ECO:0000313 with EMBL:CAA92109.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSGALP00000013566)
External Links
UniProt	Q91000
EMBL	AADN03005944 Z68093
RefSeq	NP_990046.1
UniGene	Gga.1751
SMR	Q91000
STRING	9031.ENSGALP00000013566
MEROPS	S08.071
PaxDb	Q91000
Ensembl	ENSGALT00000013581
GeneID	395457
KEGG	gga:395457
CTD	5045
eggNOG	COG4935
GeneTree	ENSGT00750000117358
HOGENOM	HOG000192536
HOVERGEN	HBG008705
KO	K01349
OMA	IDILMEP
OrthoDB	EOG7BW0JD
PhylomeDB	Q91000
TreeFam	TF314277
Reactome	REACT_197118 REACT_197191 REACT_197231 REACT_198094 REACT_198164 REACT_232279 REACT_257767 REACT_258033
NextBio	20815541
PMAP-CutDB	Q91000
PRO	PR:Q91000
Proteomes	UP000000539
GO	GO:0009986 GO:0005615 GO:0070062 GO:0005794 GO:0045121 GO:0005802 GO:0030140 GO:0042277 GO:0004252 GO:0004867 GO:0008283 GO:0032804 GO:0032911 GO:0032902 GO:0043043 GO:0016486 GO:0009966 GO:0032940 GO:0006465 GO:0019058
Gene3D	2.60.120.260 3.40.50.200
InterPro	IPR006212 IPR008979 IPR009030 IPR000209 IPR023827 IPR022398 IPR023828 IPR015500 IPR009020 IPR002884
PANTHER	PTHR10795
Pfam	PF01483 PF00082
PRINTS	PR00723
SMART	SM00261
SUPFAM	SSF49785 SSF52743 SSF54897 SSF57184
PROSITE	PS00136 PS00137 PS00138

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0030173	integral component of Golgi membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000082856 UniProtKB:Q16549	C	Seeded From UniProt	complete
involved_in	GO:0016486	peptide hormone processing	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97515 PANTHER:PTN000082901 RGD:3246 UniProtKB:P09958 UniProtKB:P29122 UniProtKB:Q92824 WB:WBGene00002232	P	Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023179 MGI:MGI:102897 MGI:MGI:97511 MGI:MGI:97512 MGI:MGI:97513 MGI:MGI:97515 PANTHER:PTN002451026 PomBase:SPAC22E12.09c RGD:3246 RGD:3272 RGD:3273 RGD:3274 UniProtKB:A0A1D8PEG3 UniProtKB:G5EB75 UniProtKB:P09958 UniProtKB:P16519 UniProtKB:P29122 UniProtKB:Q16549 UniProtKB:Q6UW60 UniProtKB:Q92824 WB:WBGene00000088 WB:WBGene00001172 WB:WBGene00002232	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004509 MGI:MGI:97514 PANTHER:PTN002451026 PomBase:SPAC22E12.09c RGD:3274 RGD:620326 UniProtKB:O05458 UniProtKB:O05461 UniProtKB:O53695 UniProtKB:P09958 UniProtKB:P16519 UniProtKB:Q16549 UniProtKB:Q8IHZ5	C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000082856 RGD:3272 RGD:620326 SGD:S000005182 UniProtKB:P09958	C	Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004509 FB:FBgn0004598 MGI:MGI:97511 MGI:MGI:97512 MGI:MGI:97513 MGI:MGI:97515 PANTHER:PTN002451026 PomBase:SPAC22E12.09c RGD:3272 RGD:3273 RGD:3274 SGD:S000005182 UniProtKB:A0A1D8PEG3 UniProtKB:G5EB75 UniProtKB:O05461 UniProtKB:P09958 UniProtKB:P16519 UniProtKB:P29122 UniProtKB:Q92824 WB:WBGene00000088 WB:WBGene00001172 WB:WBGene00002232	F	Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P	Seeded From UniProt	complete
involved_in	GO:1901394	positive regulation of transforming growth factor beta1 activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
involved_in	GO:0090472	dibasic protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
involved_in	GO:0052548	regulation of endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
enables	GO:0048406	nerve growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C	Seeded From UniProt	complete
involved_in	GO:0043043	peptide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F	Seeded From UniProt	complete
involved_in	GO:0042176	regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
involved_in	GO:0032940	secretion by cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
involved_in	GO:0032911	negative regulation of transforming growth factor beta1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
involved_in	GO:0032902	nerve growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
involved_in	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
involved_in	GO:0031638	zymogen activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
part_of	GO:0030140	trans-Golgi network transport vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C	Seeded From UniProt	complete
involved_in	GO:0019058	viral life cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
involved_in	GO:0016486	peptide hormone processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F	Seeded From UniProt	complete
involved_in	GO:0006465	signal peptide processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	P	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C	Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F	Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F	Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	F	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09958 ensembl:ENSP00000483552	C	Seeded From UniProt	complete
involved_in	GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23188 ensembl:ENSMUSP00000113793	P	Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23188 ensembl:ENSMUSP00000113793	P	Seeded From UniProt	complete
involved_in	GO:0009966	regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23188 ensembl:ENSMUSP00000113793	P	Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000209 InterPro:IPR002884 InterPro:IPR036852	F	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000209 InterPro:IPR002884 InterPro:IPR036852	P	Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:Q91000

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