CHICK:Q8JHU1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	LXR (ECO:0000313 with EMBL:AAM90897.1) (synonyms: NR1H3 (ECO:0000313 with Ensembl:ENSGALP00000013341))
Protein Name(s)	Liver X receptor (ECO:0000313 with EMBL:AAM90897.1) Uncharacterized protein (ECO:0000313 with EMBL:CAH65342.1, ECO:0000313 with Ensembl:ENSGALP00000013341)
External Links
UniProt	Q8JHU1
EMBL	AADN03004615 AF492498 AJ851708
RefSeq	NP_989873.1
UniGene	Gga.4130
SMR	Q8JHU1
Ensembl	ENSGALT00000013356
GeneID	395221
KEGG	gga:395221
CTD	10062
GeneTree	ENSGT00760000118837
HOVERGEN	HBG108655
KO	K08536
OMA	GRCEMDM
OrthoDB	EOG7DC25S
PhylomeDB	Q8JHU1
TreeFam	TF352167
Reactome	REACT_258806
NextBio	20815310
PRO	PR:Q8JHU1
Proteomes	UP000000539
GO	GO:0005634 GO:0035326 GO:0004879 GO:0000978 GO:0001077 GO:0043565 GO:0003707 GO:0008270 GO:0044255 GO:0071222 GO:0042632 GO:0010887 GO:0050728 GO:0043031 GO:0090188 GO:0045861 GO:0090341 GO:0000122 GO:0010875 GO:0045944 GO:2000188 GO:0070328
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR023257 IPR008946 IPR000536 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR02034 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20837115^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:20837115^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0035326	enhancer binding	PMID:20837115^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352464 PANTHER:PTN000637752 UniProtKB:Q13133	P	Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352463 PANTHER:PTN000637752 ZFIN:ZDB-GENE-050410-7	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637816	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 PANTHER:PTN000637752 UniProtKB:Q13133	P	Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637752 RGD:61909	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 PANTHER:PTN000637752 RGD:628831	P	Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F	Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Demeure, O et al. (2011) Regulation of LPCAT3 by LXR. Gene 470 7-11 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20837115-1] 1.0 ^1.1 ^1.2 Demeure, O et al. (2011) Regulation of LPCAT3 by LXR. Gene 470 7-11 PubMed GONUTS page

[PMID:21873635-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:Q8JHU1

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