CHICK:Q2LAI0

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	No Information Provided.
Protein Name(s)	5'-AMP-activated protein kinase alpha-2 catalytic subunit (ECO:0000313 with EMBL:ABC67730.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSGALP00000017580)
External Links
UniProt	Q2LAI0
EMBL	AADN03005680 DQ340396
RefSeq	NP_001034694.1
UniGene	Gga.33715
SMR	Q2LAI0
STRING	9031.ENSGALP00000017580
PaxDb	Q2LAI0
Ensembl	ENSGALT00000017601
GeneID	429110
KEGG	gga:429110
CTD	5563
eggNOG	COG0515
GeneTree	ENSGT00760000118892
HOGENOM	HOG000233016
HOVERGEN	HBG050432
KO	K07198
OMA	TMHIPPG
OrthoDB	EOG7RRF6K
PhylomeDB	Q2LAI0
TreeFam	TF314032
Reactome	REACT_197188 REACT_221750 REACT_231579 REACT_242846 REACT_248434 REACT_249335
NextBio	20829934
PRO	PR:Q2LAI0
Proteomes	UP000000539
GO	GO:0005634 GO:0004679 GO:0005524 GO:0003682 GO:0035174 GO:0004712 GO:0042149 GO:0042593 GO:0008610 GO:0043066 GO:0032007 GO:0010508 GO:0042752
InterPro	IPR028375 IPR011009 IPR028783 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24343:SF82
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF103243 SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1904101	response to acadesine	PMID:20802119^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:20802119^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0031649	heat generation	PMID:20802119^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:22771832^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:17213310^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:17213310^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(CHEBI:44241) has_input:(CHEBI:26523)\|has_input:(CHEBI:26523) has_input:(CHEBI:8069)	Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:17213310^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0010628)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17213310^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q0GGW5	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:17213310^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(CHEBI:8069)\|has_participant:(CHEBI:44241)	Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336173 MGI:MGI:2145955 PANTHER:PTN001217363	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336173 MGI:MGI:2145955 PANTHER:PTN001217363	P		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001217363 RGD:3387 RGD:620893	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q7XQP4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q5N942 UniProtKB:Q7XQP4 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F		Seeded From UniProt	complete
involved_in	GO:0035404	histone-serine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0035174	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54646 ensembl:ENSP00000360290	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54646 ensembl:ENSP00000360290	C		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54646 ensembl:ENSP00000360290	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54646 ensembl:ENSP00000360290	F		Seeded From UniProt	complete
involved_in	GO:2000758	positive regulation of peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:1904428	negative regulation of tubulin deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:1903829	positive regulation of cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0071380	cellular response to prostaglandin E stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0062028	regulation of stress granule assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	C		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	F		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0031669	cellular response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	C		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	C		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	C		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039148	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Walter, I et al. (2010) AMP-activated protein kinase controls metabolism and heat production during embryonic development in birds. J. Exp. Biol. 213 3167-76 PubMed GONUTS page
↑ Song, Z et al. (2012) Fasting alters protein expression of AMP-activated protein kinase in the hypothalamus of broiler chicks (Gallus gallus domesticus). Gen. Comp. Endocrinol. 178 546-55 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Blättler, SM et al. (2007) In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase. Proc. Natl. Acad. Sci. U.S.A. 104 1045-50 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20802119-1] 1.0 ^1.1 ^1.2 Walter, I et al. (2010) AMP-activated protein kinase controls metabolism and heat production during embryonic development in birds. J. Exp. Biol. 213 3167-76 PubMed GONUTS page

[PMID:22771832-2] Song, Z et al. (2012) Fasting alters protein expression of AMP-activated protein kinase in the hypothalamus of broiler chicks (Gallus gallus domesticus). Gen. Comp. Endocrinol. 178 546-55 PubMed GONUTS page

[PMID:17213310-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Blättler, SM et al. (2007) In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase. Proc. Natl. Acad. Sci. U.S.A. 104 1045-50 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:Q2LAI0

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