CHICK:PTN11

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	PTPN11
Protein Name(s)	Tyrosine-protein phosphatase non-receptor type 11 SH-PTP2 cSH-PTP2
External Links
UniProt	Q90687
EMBL	U38620
PIR	JC5167
RefSeq	NP_990299.1
UniGene	Gga.482
ProteinModelPortal	Q90687
SMR	Q90687
STRING	9031.ENSGALP00000033730
PaxDb	Q90687
PRIDE	Q90687
Ensembl	ENSGALT00000007704
GeneID	395815
KEGG	gga:395815
CTD	5781
eggNOG	COG5599
GeneTree	ENSGT00770000120452
HOGENOM	HOG000273907
HOVERGEN	HBG000223
InParanoid	Q90687
KO	K07293
OMA	IVIDILM
PhylomeDB	Q90687
Reactome	REACT_194391 REACT_194398 REACT_197052 REACT_197119 REACT_197153 REACT_197530 REACT_197533 REACT_197538 REACT_198076 REACT_204997 REACT_207556 REACT_217737 REACT_230783 REACT_231139 REACT_235454 REACT_239556 REACT_239808 REACT_240004 REACT_244511 REACT_244793 REACT_251680 REACT_258049 REACT_260156
NextBio	20815883
PRO	PR:Q90687
Proteomes	UP000000539
GO	GO:0005737 GO:0005634 GO:0004726 GO:0033277 GO:0000187 GO:0036302 GO:0007409 GO:0007420 GO:0000077 GO:0048013 GO:0038127 GO:0060325 GO:0048806 GO:0042593 GO:0042445 GO:0009755 GO:0048839 GO:0007229 GO:0035855 GO:0048609 GO:0033629 GO:0051463 GO:0060125 GO:0046676 GO:0048011 GO:0035265 GO:0030220 GO:2001275 GO:0046887 GO:0040014 GO:0046825 GO:0006641
Gene3D	3.30.505.10 3.90.190.10
InterPro	IPR029021 IPR000980 IPR000387 IPR016130 IPR012152 IPR000242
Pfam	PF00017 PF00102
PIRSF	PIRSF000929
PRINTS	PR00700 PR00401
SMART	SM00194 SM00252
SUPFAM	SSF52799 SSF55550
PROSITE	PS50001 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	C	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06124	F	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0061582	intestinal epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0060125	negative regulation of growth hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0060020	Bergmann glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0051463	negative regulation of cortisol secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F	Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F	Seeded From UniProt	complete
involved_in	GO:0048873	homeostasis of number of cells within a tissue	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0048609	multicellular organismal reproductive process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0046888	negative regulation of hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0046887	positive regulation of hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0046825	regulation of protein export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0042445	hormone metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0035855	megakaryocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0035265	organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0033629	negative regulation of cell adhesion mediated by integrin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0033277	abortive mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0032528	microvillus organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F	Seeded From UniProt	complete
involved_in	GO:0030220	platelet formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0021697	cerebellar cortex formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F	Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0006641	triglyceride metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F	Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P	Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0048806	genitalia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0043254	regulation of protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0038127	ERBB signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0033628	regulation of cell adhesion mediated by integrin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	C	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	C	Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F	Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F	Seeded From UniProt	complete
enables	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F	Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F	Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06124 ensembl:ENSP00000489597	F	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR012152 InterPro:IPR016130	F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR012152	P	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P	Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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CHICK:PTN11

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