CHICK:NF2L1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	NFE2L1 (synonyms: NRF1)
Protein Name(s)	Nuclear factor erythroid 2-related factor 1 NF-E2-related factor 1 NFE2-related factor 1 Nuclear factor, erythroid derived 2, like 1
External Links
UniProt	Q5ZL67
EMBL	AJ719867
RefSeq	NP_001025927.1
UniGene	Gga.31932
ProteinModelPortal	Q5ZL67
STRING	9031.ENSGALP00000019444
PaxDb	Q5ZL67
PRIDE	Q5ZL67
GeneID	417987
KEGG	gga:417987
CTD	4779
eggNOG	NOG309753
HOGENOM	HOG000234410
HOVERGEN	HBG052609
InParanoid	Q5ZL67
KO	K09040
PhylomeDB	Q5ZL67
NextBio	20821211
PRO	PR:Q5ZL67
Proteomes	UP000000539
ExpressionAtlas	Q5ZL67
GO	GO:0005789 GO:0016021 GO:0005634 GO:0001190 GO:0043565 GO:0003700 GO:0030218
Gene3D	1.10.880.10
InterPro	IPR004827 IPR004826 IPR029847 IPR008917
PANTHER	PTHR24411:SF26
Pfam	PF03131
SMART	SM00338
SUPFAM	SSF47454
PROSITE	PS50217 PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696622	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696622 RGD:620360 UniProtKB:Q16236	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 MGI:MGI:97308 MGI:MGI:99421 PANTHER:PTN000696622 RGD:620360 UniProtKB:Q14494 UniProtKB:Q16236 ZFIN:ZDB-GENE-030723-2	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696622 UniProtKB:Q16236 ZFIN:ZDB-GENE-030723-2	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000696622 RGD:620360 ZFIN:ZDB-GENE-030723-2	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826 InterPro:IPR008917	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826 InterPro:IPR004827 InterPro:IPR008917	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029847	P		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:29149604^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000076448	F		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:29149604^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000076448	P		Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	PMID:29149604^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000076448	P		Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	PMID:27528193^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14494:PRO_0000076447	C		Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	PMID:24448410^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14494:PRO_0000076447	C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:22586274^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:22586274^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	F		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:22586274^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:20385086^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:20385086^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	F		Seeded From UniProt	complete
involved_in	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	PMID:20385086^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:11342101^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:11342101^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	F		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	PMID:11342101^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	P		Seeded From UniProt	complete
involved_in	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	PMID:11342101^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:11342101^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:10601325^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:10601325^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	F		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	PMID:10601325^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	P		Seeded From UniProt	complete
involved_in	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	PMID:10601325^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:10601325^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:29149604^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	C		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:29149604^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:29149604^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	F		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:29149604^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	P		Seeded From UniProt	complete
involved_in	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	PMID:29149604^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61985:PRO_0000443104	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:15308669^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14494:PRO_0000443103	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:1901329	regulation of odontoblast differentiation	PMID:15308669^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14494:PRO_0000443103	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15308669^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14494:PRO_0000443103	P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:8932385^[10]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14494:PRO_0000443103	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24448410^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14494:PRO_0000443103	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Widenmaier, SB et al. (2017) NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Cell 171 1094-1109.e15 PubMed GONUTS page
↑ Koizumi, S et al. (2016) The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. Elife 5 PubMed GONUTS page
↑ ^4.0 ^4.1 Radhakrishnan, SK et al. (2014) p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. Elife 3 e01856 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hirotsu, Y et al. (2012) NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes. Mol. Cell. Biol. 32 2760-70 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Radhakrishnan, SK et al. (2010) Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Mol. Cell 38 17-28 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Myhrstad, MC et al. (2001) TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter. Biochim. Biophys. Acta 1517 212-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Kwong, M et al. (1999) The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts. J. Biol. Chem. 274 37491-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Narayanan, K et al. (2004) The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation. J. Biol. Chem. 279 45423-32 PubMed GONUTS page
↑ Johnsen, O et al. (1996) Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. Nucleic Acids Res. 24 4289-97 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:29149604-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Widenmaier, SB et al. (2017) NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Cell 171 1094-1109.e15 PubMed GONUTS page

[PMID:27528193-3] Koizumi, S et al. (2016) The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. Elife 5 PubMed GONUTS page

[PMID:24448410-4] 4.0 ^4.1 Radhakrishnan, SK et al. (2014) p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. Elife 3 e01856 PubMed GONUTS page

[PMID:22586274-5] 5.0 ^5.1 ^5.2 Hirotsu, Y et al. (2012) NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes. Mol. Cell. Biol. 32 2760-70 PubMed GONUTS page

[PMID:20385086-6] 6.0 ^6.1 ^6.2 Radhakrishnan, SK et al. (2010) Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Mol. Cell 38 17-28 PubMed GONUTS page

[PMID:11342101-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Myhrstad, MC et al. (2001) TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter. Biochim. Biophys. Acta 1517 212-9 PubMed GONUTS page

[PMID:10601325-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Kwong, M et al. (1999) The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts. J. Biol. Chem. 274 37491-8 PubMed GONUTS page

[PMID:15308669-9] 9.0 ^9.1 ^9.2 Narayanan, K et al. (2004) The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation. J. Biol. Chem. 279 45423-32 PubMed GONUTS page

[PMID:8932385-10] Johnsen, O et al. (1996) Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. Nucleic Acids Res. 24 4289-97 PubMed GONUTS page

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CHICK:NF2L1

Contents

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