CHICK:HMGB2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	HMGB2 (synonyms: HMG2)
Protein Name(s)	High mobility group protein B2 High mobility group protein 2 HMG-2
External Links
UniProt	P26584
EMBL	M83235 M80574
PIR	JC1114 JC1129
RefSeq	NP_990817.1
UniGene	Gga.4061
ProteinModelPortal	P26584
SMR	P26584
BioGrid	676729
STRING	9031.ENSGALP00000017462
PaxDb	P26584
PRIDE	P26584
GeneID	396482
KEGG	gga:396482
CTD	3148
eggNOG	NOG320947
HOGENOM	HOG000197861
HOVERGEN	HBG009000
InParanoid	P26584
KO	K11295
PhylomeDB	P26584
NextBio	20816521
PRO	PR:P26584
Proteomes	UP000000539
GO	GO:0000793 GO:0005737 GO:0005615 GO:0005634 GO:0048471 GO:0008301 GO:0008144 GO:0000400 GO:0050829 GO:0050830 GO:0032392 GO:0002437 GO:0006357 GO:0042493 GO:0032496
Gene3D	1.10.30.10
InterPro	IPR009071 IPR017967 IPR031075
PANTHER	PTHR13711:SF181
Pfam	PF00505 PF09011
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS00353 PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5U071	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5U071	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:X2JGB1	P	occurs_in:(CL:0000738) occurs_in:(UBERON:0002106) occurs_in:(UBERON:0002113)	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:X2JGB1	P	occurs_in:(UBERON:0002106) occurs_in:(UBERON:0002113)	Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	PMID:11080451^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:11080451^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032392	DNA geometric change	PMID:11080451^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	C		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	P		Seeded From UniProt	complete
involved_in	GO:0002437	inflammatory response to antigenic stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0002437	inflammatory response to antigenic stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	C		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	C		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P26583 WB:WBGene00001972	P		Seeded From UniProt	complete
involved_in	GO:0045089	positive regulation of innate immune response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P12682	P		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004362 FB:FBgn0278608 PANTHER:PTN000345179 RGD:2802 SGD:S000002157 SGD:S000004676 SGD:S000006256 UniProtKB:F1RJ01 UniProtKB:F2Z594 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P12682 UniProtKB:P17741 UniProtKB:P26583 UniProtKB:P26584 UniProtKB:P40618 UniProtKB:P40673 UniProtKB:Q32L31 UniProtKB:Q8I616 UniProtKB:Q8IB14 UniProtKB:Q9YH06	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0278608 MGI:MGI:96157 PANTHER:PTN000345179 RGD:2802 UniProtKB:P09429	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0278608 MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN000346026 UniProtKB:P09429 UniProtKB:P26583 WB:WBGene00001972	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000345179 SGD:S000002157 SGD:S000006256	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P40673 UniProtKB:Q32L31	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 RGD:2802 UniProtKB:P26583	C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96157 PANTHER:PTN000346026 SGD:S000002160 UniProtKB:F1RJ01 UniProtKB:F2Z594 UniProtKB:P12682 UniProtKB:P17741	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017967	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017967	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Lee, KB & Thomas, JO (2000) The effect of the acidic tail on the DNA-binding properties of the HMG1,2 class of proteins: insights from tail switching and tail removal. J. Mol. Biol. 304 135-49 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11080451-1] 1.0 ^1.1 ^1.2 Lee, KB & Thomas, JO (2000) The effect of the acidic tail on the DNA-binding properties of the HMG1,2 class of proteins: insights from tail switching and tail removal. J. Mol. Biol. 304 135-49 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:HMGB2

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