CHICK:HMGB1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	HMGB1 (synonyms: HMG1)
Protein Name(s)	High mobility group protein B1 High mobility group protein 1 HMG-1
External Links
UniProt	Q9YH06
EMBL	Y17968 AJ851648 AF178849 AADN03000868 AADN03001640 JQ040530
RefSeq	NP_990233.1
UniGene	Gga.4638
ProteinModelPortal	Q9YH06
SMR	Q9YH06
STRING	9031.ENSGALP00000027541
Ensembl	ENSGALT00000027593
GeneID	395724
KEGG	gga:395724
CTD	3146
GeneTree	ENSGT00760000119164
HOGENOM	HOG000197861
HOVERGEN	HBG009000
InParanoid	Q9YH06
KO	K10802
OMA	AFFFYSQ
OrthoDB	EOG7WHHBQ
PhylomeDB	Q9YH06
TreeFam	TF105371
Reactome	REACT_332741
NextBio	20815793
PRO	PR:Q9YH06
Proteomes	UP000000539
GO	GO:0005623 GO:0009986 GO:0000793 GO:0005615 GO:0005634 GO:0017053 GO:0000405 GO:0003682 GO:0008301 GO:0000400 GO:0044378 GO:0044822 GO:0003700 GO:0097100 GO:0006288 GO:0006338 GO:0032392 GO:0051103 GO:0002437 GO:2000426 GO:0043537 GO:0017055 GO:0043280 GO:0043388 GO:0045944 GO:0006355 GO:0033151
Gene3D	1.10.30.10
InterPro	IPR009071 IPR017967 IPR031076
PANTHER	PTHR13711:SF157
Pfam	PF00505 PF09011
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS00353 PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005623	cell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12682	C	Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F2Z594	C	Seeded From UniProt	complete
involved_in	GO:0051103	DNA ligation involved in DNA repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F2Z594	P	Seeded From UniProt	complete
enables	GO:0044378	non-sequence-specific DNA binding, bending	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12682	F	Seeded From UniProt	complete
enables	GO:0044378	non-sequence-specific DNA binding, bending	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F2Z594	F	Seeded From UniProt	complete
enables	GO:0000405	bubble DNA binding	PMID:11080451^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0097100	supercoiled DNA binding	PMID:11080451^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	PMID:11080451^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:11080451^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0032392	DNA geometric change	PMID:11080451^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902741	positive regulation of interferon-alpha secretion	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002672476 UniProtKB:P10103	P	Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 UniProtKB:P12682	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 UniProtKB:P09429	P	Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 UniProtKB:P10103	P	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476	P	Seeded From UniProt	complete
involved_in	GO:0050716	positive regulation of interleukin-1 secretion	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 UniProtKB:P09429	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P26583 WB:WBGene00001972	P	Seeded From UniProt	complete
involved_in	GO:0045089	positive regulation of innate immune response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P12682	P	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 RGD:2802	P	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 RGD:2802 UniProtKB:P09429	P	Seeded From UniProt	complete
involved_in	GO:0032502	developmental process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 RGD:2802 UniProtKB:P09429 UniProtKB:P10103 ZFIN:ZDB-GENE-030131-341	P	Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002672476 RGD:2802	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 RGD:2802 UniProtKB:P10103	P	Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004362 FB:FBgn0278608 PANTHER:PTN000345179 RGD:2802 SGD:S000002157 SGD:S000004676 SGD:S000006256 UniProtKB:F1RJ01 UniProtKB:F2Z594 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P12682 UniProtKB:P17741 UniProtKB:P26583 UniProtKB:P26584 UniProtKB:P40618 UniProtKB:P40673 UniProtKB:Q32L31 UniProtKB:Q8I616 UniProtKB:Q8IB14 UniProtKB:Q9YH06	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0278608 MGI:MGI:96157 PANTHER:PTN000345179 RGD:2802 UniProtKB:P09429	F	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0278608 MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN000346026 UniProtKB:P09429 UniProtKB:P26583 WB:WBGene00001972	P	Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000345179 SGD:S000002157 SGD:S000006256	P	Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P40673 UniProtKB:Q32L31	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 RGD:2802 UniProtKB:P26583	C	Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002672476 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P12682	P	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96157 PANTHER:PTN000346026 SGD:S000002160 UniProtKB:F1RJ01 UniProtKB:F2Z594 UniProtKB:P12682 UniProtKB:P17741	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017967	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017967	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Lee, KB & Thomas, JO (2000) The effect of the acidic tail on the DNA-binding properties of the HMG1,2 class of proteins: insights from tail switching and tail removal. J. Mol. Biol. 304 135-49 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11080451-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Lee, KB & Thomas, JO (2000) The effect of the acidic tail on the DNA-binding properties of the HMG1,2 class of proteins: insights from tail switching and tail removal. J. Mol. Biol. 304 135-49 PubMed GONUTS page

[PMID:21873635-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:HMGB1

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