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CHICK:HDAC3

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) HDAC3
Protein Name(s) Histone deacetylase 3

HD3

External Links
UniProt P56520
EMBL AF039753
RefSeq NP_990078.1
UniGene Gga.2110
ProteinModelPortal P56520
BioGrid 675790
STRING 9031.ENSGALP00000004141
PaxDb P56520
PRIDE P56520
GeneID 395506
KEGG gga:395506
CTD 8841
eggNOG COG0123
HOGENOM HOG000225180
HOVERGEN HBG057112
InParanoid P56520
KO K11404
PhylomeDB P56520
NextBio 20815585
PRO PR:P56520
Proteomes UP000000539
GO GO:0005737
GO:0000118
GO:0005634
GO:0017053
GO:0003682
GO:0004407
GO:0032041
GO:0070491
GO:0003714
GO:0008134
GO:0016568
GO:0000122
GO:0006351
Gene3D 3.40.800.20
InterPro IPR000286
IPR003084
IPR023801
PANTHER PTHR10625
Pfam PF00850
PIRSF PIRSF037913
PRINTS PR01270
PR01271

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0003714

transcription corepressor activity

PMID:19604314[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

part_of:(UBERON:0001134)

Seeded From UniProt

complete

enables

GO:0070491

repressing transcription factor binding

PMID:19604314[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O42394

F

part_of:(UBERON:0001134)

Seeded From UniProt

complete

part_of

GO:0017053

transcriptional repressor complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O15379

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O15379

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O15379

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O15379

P

Seeded From UniProt

complete

involved_in

GO:0070933

histone H4 deacetylation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108086
MGI:MGI:1097691
MGI:MGI:1343091
PANTHER:PTN002578320
PomBase:SPAC3G9.07c
SGD:S000005274
SGD:S000006272
UniProtKB:G5EB64
UniProtKB:Q13547

P

Seeded From UniProt

complete

involved_in

GO:0070932

histone H3 deacetylation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108086
MGI:MGI:1097691
PANTHER:PTN002578320
RGD:1309799
RGD:619976
RGD:619977
SGD:S000005274
TAIR:locus:2098115
UniProtKB:G5EB64
UniProtKB:Q13547

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002578320
PomBase:SPBC36.05c
SGD:S000005274
SGD:S000006272
UniProtKB:O15379
UniProtKB:Q13547
UniProtKB:Q92769
WB:WBGene00001834

P

Seeded From UniProt

complete

enables

GO:0004407

histone deacetylase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015805
FB:FBgn0025825
MGI:MGI:108086
MGI:MGI:1097691
PANTHER:PTN002578320
PomBase:SPAC3G9.07c
PomBase:SPBC36.05c
RGD:1309799
RGD:619976
SGD:S000003162
SGD:S000005274
TAIR:locus:2162017
UniProtKB:G5EB64
UniProtKB:O15379
UniProtKB:Q13547
UniProtKB:Q7K6A1
UniProtKB:Q92769
WB:WBGene00001834
dictyBase:DDB_G0270338

F

Seeded From UniProt

complete

part_of

GO:0000118

histone deacetylase complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015805
MGI:MGI:108086
PANTHER:PTN002578320
PomBase:SPAC3G9.07c
PomBase:SPBC36.05c
SGD:S000003162
SGD:S000005274
SGD:S000006272
UniProtKB:Q13547
UniProtKB:Q92769
WB:WBGene00001834

C

Seeded From UniProt

complete

enables

GO:0004407

histone deacetylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003084

F

Seeded From UniProt

complete

involved_in

GO:0016575

histone deacetylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003084

P

Seeded From UniProt

complete

enables

GO:0004407

histone deacetylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.98

F

Seeded From UniProt

complete

enables

GO:0032041

NAD-dependent histone deacetylase activity (H3-K14 specific)

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.98

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

PMID:12711221[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:12711221[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12711221[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12711221[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004407

histone deacetylase activity

PMID:12711221[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000118

histone deacetylase complex

PMID:12711221[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Mathew, S et al. (2009) Repression of the cardiac myosin light chain-2 gene in skeletal muscle requires site-specific association of antithetic regulator, Nished, and HDACs. J. Cell. Mol. Med. 13 1952-61 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page