CHICK:G3P

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	GAPDH (synonyms: GAPD)
Protein Name(s)	Glyceraldehyde-3-phosphate dehydrogenase GAPDH Peptidyl-cysteine S-nitrosylase GAPDH
External Links
UniProt	P00356
EMBL	K01458 V00407 M11213 AF047874 V00406 X01578
PIR	A00368
RefSeq	NP_989636.1
UniGene	Gga.6383
ProteinModelPortal	P00356
SMR	P00356
BioGrid	675216
IntAct	P00356
STRING	9031.ENSGALP00000036329
PaxDb	P00356
PRIDE	P00356
GeneID	374193
KEGG	gga:374193
CTD	2597
eggNOG	COG0057
HOGENOM	HOG000071678
HOVERGEN	HBG000227
InParanoid	P00356
KO	K00134
PhylomeDB	P00356
Reactome	REACT_115534 REACT_115767 REACT_284496 REACT_352557
UniPathway	UPA00109
NextBio	20813697
PRO	PR:P00356
Proteomes	UP000000539
ExpressionAtlas	P00356
GO	GO:0005737 GO:0005829 GO:0070062 GO:0097452 GO:0005811 GO:0015630 GO:0031965 GO:0005634 GO:0005886 GO:0030529 GO:0004365 GO:0008017 GO:0051287 GO:0050661 GO:0035605 GO:0005975 GO:0071346 GO:0006094 GO:0006096 GO:0000226 GO:0043066 GO:0017148 GO:0051402 GO:0000740 GO:0035606 GO:0050821 GO:0044281
Gene3D	3.40.50.720
InterPro	IPR020831 IPR020830 IPR020829 IPR020828 IPR006424 IPR016040
PANTHER	PTHR10836
Pfam	PF02800 PF00044
PIRSF	PIRSF000149
PRINTS	PR00078
SMART	SM00846
TIGRFAMs	TIGR01534
PROSITE	PS00071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0016020	membrane	PMID:26221766^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12651855^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:6687938^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	PMID:6687938^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000740	nuclear membrane fusion	PMID:12651855^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	P	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	P	Seeded From UniProt	complete
involved_in	GO:0035606	peptidyl-cysteine S-trans-nitrosylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	P	Seeded From UniProt	complete
enables	GO:0035605	peptidyl-cysteine S-nitrosylase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	F	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	C	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	C	Seeded From UniProt	complete
enables	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	F	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04797	P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10367 FB:FBgn0001091 FB:FBgn0001092 MGI:MGI:95653 PANTHER:PTN000089473 RGD:2661 SGD:S000003424 SGD:S000003588 SGD:S000003769 TAIR:locus:2103085	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10367 MGI:MGI:95640 PANTHER:PTN000089473 RGD:2661 SGD:S000003424 SGD:S000003588 SGD:S000003769 TAIR:locus:2103085 UniProtKB:M0R590 UniProtKB:P04406 UniProtKB:Q8IKK7 UniProtKB:Q9FX54	C	Seeded From UniProt	complete
enables	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10367 FB:FBgn0001091 FB:FBgn0001092 MGI:MGI:95640 MGI:MGI:95653 PANTHER:PTN000089473 RGD:2661 SGD:S000003424 SGD:S000003588 SGD:S000003769 TAIR:locus:2032810 TAIR:locus:2206435 UniProtKB:M0R590 UniProtKB:O14556 UniProtKB:P04406 UniProtKB:P20445 UniProtKB:Q9FX54	F	Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	F	Seeded From UniProt	complete
part_of	GO:0097452	GAIT complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	P	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	P	Seeded From UniProt	complete
involved_in	GO:0052501	positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	P	Seeded From UniProt	complete
involved_in	GO:0051873	killing by host of symbiont cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	P	Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	P	Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	F	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	P	Seeded From UniProt	complete
enables	GO:0019828	aspartic-type endopeptidase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	F	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	P	Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04406 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HVZ4 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HVZ4 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HVZ4 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HVZ4 ensembl:ENSP00000229239	C	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006424	P	Seeded From UniProt	complete
enables	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006424 InterPro:IPR020828 InterPro:IPR020829 InterPro:IPR020830 InterPro:IPR020831	F	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006424	F	Seeded From UniProt	complete
enables	GO:0051287	NAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006424	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006424 InterPro:IPR020828 InterPro:IPR020829 InterPro:IPR020830 InterPro:IPR020831	P	Seeded From UniProt	complete
enables	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.2.1.12	F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	Reactome:R-GGA-352882	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	Reactome:R-GGA-352875	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-GGA-352956 Reactome:R-GGA-352921	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324 UniPathway:UPA00109	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ren, X et al. (2015) Binding chicken Anx2 is beneficial for infection with infectious bursal disease virus. Virus Res. 210 232-40 PubMed GONUTS page
↑ ^2.0 ^2.1 Nakagawa, T et al. (2003) Participation of a fusogenic protein, glyceraldehyde-3-phosphate dehydrogenase, in nuclear membrane assembly. J. Biol. Chem. 278 20395-404 PubMed GONUTS page
↑ ^3.0 ^3.1 Milner, RJ et al. (1983) Glyceraldehyde 3-phosphate dehydrogenase protein and mRNA are both differentially expressed in adult chickens but not chick embryos. Nucleic Acids Res. 11 3301-15 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26221766-1] Ren, X et al. (2015) Binding chicken Anx2 is beneficial for infection with infectious bursal disease virus. Virus Res. 210 232-40 PubMed GONUTS page

[PMID:12651855-2] 2.0 ^2.1 Nakagawa, T et al. (2003) Participation of a fusogenic protein, glyceraldehyde-3-phosphate dehydrogenase, in nuclear membrane assembly. J. Biol. Chem. 278 20395-404 PubMed GONUTS page

[PMID:6687938-3] 3.0 ^3.1 Milner, RJ et al. (1983) Glyceraldehyde 3-phosphate dehydrogenase protein and mRNA are both differentially expressed in adult chickens but not chick embryos. Nucleic Acids Res. 11 3301-15 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:G3P

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