CHICK:FOXD3

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	FOXD3
Protein Name(s)	Forkhead box protein D3 HNF3/FH transcription factor genesis Winged-helix protein CWH-3
External Links
UniProt	P79772
EMBL	U37274
RefSeq	NP_990282.1
UniGene	Gga.468
ProteinModelPortal	P79772
SMR	P79772
STRING	9031.ENSGALP00000035264
GeneID	395794
KEGG	gga:395794
CTD	27022
HOVERGEN	HBG051641
InParanoid	P79772
KO	K09397
NextBio	20815862
PRO	PR:P79772
Proteomes	UP000000539
GO	GO:0005634 GO:0043565 GO:0003700 GO:0043009 GO:0000122 GO:0045944 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00657 PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001755	neural crest cell migration	PMID:11262245	ECO:0000270			P		Figure 3 shows that if you have ectopically express Foxd3, you can get ecotopic expression of HNK-1 and Cad-7 in a way that suggests that they are migrating away from the neural tube, similar to the migration of neural crest cells. HNK-1 is normally only expressed in migrating neural crest cells, so its induction by Foxd3 suggests that Foxd3 induces migratory neural crest cells.	complete
	GO:0045635	negative regulation of melanocyte differentiation	PMID:11262245	ECO:0000315			P		In figure 6 and table 1, there are results with three different Foxd3 antisense oligonucleotide treatments. When Foxd3 expression was reduced with this treatment, 38.5% of cells differentiated into melanocytes versus 18% of the control (statistically significant using Tukey analysis). This suggests that Foxd3 negatively regulated melanocyte differentiation.	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UJU5	P		Seeded From UniProt	complete
involved_in	GO:0043009	chordate embryonic development	PMID:11684651	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61060	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61060	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000930906 WB:WBGene00004013	P		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347476 PANTHER:PTN000930906	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 MGI:MGI:1347472 MGI:MGI:1347477 PANTHER:PTN000930906 UniProtKB:O00358 UniProtKB:Q9Y261 ZFIN:ZDB-GENE-000616-15	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 FB:FBgn0003430 FB:FBgn0004895 FB:FBgn0014143 MGI:MGI:1347466 MGI:MGI:1347472 MGI:MGI:1347476 MGI:MGI:1347477 MGI:MGI:1349428 MGI:MGI:1353569 MGI:MGI:1927549 MGI:MGI:95546 PANTHER:PTN000930906 PomBase:SPBC32H8.11 PomBase:SPBC4C3.12 RGD:2807 RGD:2808 RGD:2809 SGD:S000000661 SGD:S000001393 UniProtKB:O00358 UniProtKB:P55317 UniProtKB:P58012 UniProtKB:Q12948 UniProtKB:Q13461 UniProtKB:Q5AS72 UniProtKB:Q99958 UniProtKB:Q9Y261 WB:WBGene00001434 WB:WBGene00001441 WB:WBGene00002601 WB:WBGene00003017 WB:WBGene00004013 WB:WBGene00006853	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 PANTHER:PTN000930906 RGD:621723 UniProtKB:O00358 WB:WBGene00004013 ZFIN:ZDB-GENE-000616-15	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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References

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