CHICK:CH60

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	HSPD1 (ECO:0000250 with UniProtKB:P10809) (synonyms: HSP60 (ECO:0000250 with UniProtKB:P10809))
Protein Name(s)	60 kDa heat shock protein, mitochondrial 60 kDa chaperonin Chaperonin 60 CPN60 Heat shock protein 60 HSP-60 Hsp60
External Links
UniProt	Q5ZL72
EMBL	AJ719862
RefSeq	NP_001012934.1
UniGene	Gga.39003
ProteinModelPortal	Q5ZL72
SMR	Q5ZL72
BioGrid	684495
IntAct	Q5ZL72
STRING	9031.ENSGALP00000013122
PaxDb	Q5ZL72
PRIDE	Q5ZL72
Ensembl	ENSGALT00000013137
GeneID	424059
KEGG	gga:424059
CTD	3329
eggNOG	COG0459
GeneTree	ENSGT00390000005727
HOGENOM	HOG000076290
HOVERGEN	HBG001982
InParanoid	Q5ZL72
KO	K04077
OMA	MLTTDCA
OrthoDB	EOG7HTHGJ
PhylomeDB	Q5ZL72
TreeFam	TF300475
Reactome	REACT_316184
NextBio	20826441
PRO	PR:Q5ZL72
Proteomes	UP000000539
GO	GO:0009986 GO:0005905 GO:0030135 GO:0019907 GO:0005737 GO:0005829 GO:0005769 GO:0070062 GO:0005615 GO:0046696 GO:0005743 GO:0005759 GO:0043209 GO:0005886 GO:0030141 GO:0005524 GO:0003725 GO:0001530 GO:0044822 GO:0006919 GO:0002368 GO:0042100 GO:0048291 GO:0002755 GO:0043066 GO:0032727 GO:0032733 GO:0032735 GO:0032755 GO:0043032 GO:0002842 GO:0042026 GO:0006986 GO:0042110
Gene3D	1.10.560.10 3.50.7.10
HAMAP	MF_00600
InterPro	IPR018370 IPR001844 IPR002423 IPR027409 IPR027413
PANTHER	PTHR11353
Pfam	PF00118
PRINTS	PR00298
SUPFAM	SSF52029
TIGRFAMs	TIGR02348
PROSITE	PS00296

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0043025	neuronal cell body	PMID:9786217^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000740)	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:23636703^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10809	C		Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10599 PANTHER:PTN000143677 SGD:S000004249	F		Seeded From UniProt	complete
involved_in	GO:0045041	protein import into mitochondrial intermembrane space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000143508 SGD:S000004249	P		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96242 PANTHER:PTN000143515 UniProtKB:P10809	P		Seeded From UniProt	complete
involved_in	GO:0008637	apoptotic mitochondrial changes	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000143510 RGD:621314	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015245 PANTHER:PTN000888029 WB:WBGene00002025	P		Seeded From UniProt	complete
involved_in	GO:0006458	'de novo' protein folding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000143677 SGD:S000004249	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000143507 RGD:621314 TAIR:locus:2076081 TAIR:locus:2161048 UniProtKB:P10809	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015245 MGI:MGI:96242 PANTHER:PTN000888029 RGD:621314 SGD:S000004249 TAIR:locus:2057841 TAIR:locus:2076081 TAIR:locus:2087959 TAIR:locus:2092825 TAIR:locus:2161048 UniProtKB:P10809 UniProtKB:Q8IJN9 UniProtKB:Q8L7B5 WB:WBGene00002025 dictyBase:DDB_G0288181	C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
involved_in	GO:0051702	interaction with symbiont	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	F		Seeded From UniProt	complete
involved_in	GO:0050870	positive regulation of T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0048291	isotype switching to IgG isotypes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
part_of	GO:0046696	lipopolysaccharide receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0042113	B cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0042026	protein refolding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
enables	GO:0034186	apolipoprotein A-I binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	F		Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0032727	positive regulation of interferon-alpha production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	F		Seeded From UniProt	complete
part_of	GO:0030135	coated vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
enables	GO:0008035	high-density lipoprotein particle binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	F		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	F		Seeded From UniProt	complete
involved_in	GO:0002842	positive regulation of T cell mediated immune response to tumor cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
involved_in	GO:0002368	B cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	P		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	F		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10809 ensembl:ENSP00000373620	F		Seeded From UniProt	complete
involved_in	GO:0098761	cellular response to interleukin-7	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	P		Seeded From UniProt	complete
involved_in	GO:0050870	positive regulation of T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	C		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	P		Seeded From UniProt	complete
involved_in	GO:0032727	positive regulation of interferon-alpha production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	C		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63038 ensembl:ENSMUSP00000027123	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R3X4 ensembl:ENSP00000373620	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002423 InterPro:IPR018370	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001844 InterPro:IPR018370	C		Seeded From UniProt	complete
involved_in	GO:0006457	protein folding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018370	P		Seeded From UniProt	complete
involved_in	GO:0042026	protein refolding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001844	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Morales, AV et al. (1998) Heat shock proteins in retinal neurogenesis: identification of the PM1 antigen as the chick Hsc70 and its expression in comparison to that of other chaperones. Eur. J. Neurosci. 10 3237-45 PubMed GONUTS page
↑ Zhao, FQ et al. (2013) The role of heat shock proteins in inflammatory injury induced by cold stress in chicken hearts. Cell Stress Chaperones 18 773-83 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9786217-1] Morales, AV et al. (1998) Heat shock proteins in retinal neurogenesis: identification of the PM1 antigen as the chick Hsc70 and its expression in comparison to that of other chaperones. Eur. J. Neurosci. 10 3237-45 PubMed GONUTS page

[PMID:23636703-2] Zhao, FQ et al. (2013) The role of heat shock proteins in inflammatory injury induced by cold stress in chicken hearts. Cell Stress Chaperones 18 773-83 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:CH60

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Annotations

Notes

References

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