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CHICK:CAN3

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) CAPN3
Protein Name(s) Calpain-3

Calcium-activated neutral proteinase 3 CANP 3 Calpain L3 Calpain p94 Muscle-specific calcium-activated neutral protease 3

External Links
UniProt Q92177
EMBL D38028
PIR S57196
UniGene Gga.72
ProteinModelPortal Q92177
SMR Q92177
STRING 9031.ENSGALP00000031999
MEROPS C02.004
PaxDb Q92177
PRIDE Q92177
CTD 825
eggNOG NOG327523
HOGENOM HOG000232035
HOVERGEN HBG012645
InParanoid Q92177
PhylomeDB Q92177
BRENDA 3.4.22.54
NextBio 20825732
PRO PR:Q92177
Proteomes UP000000539
GO GO:0005737
GO:0005829
GO:0030016
GO:0005634
GO:0005886
GO:0043234
GO:0030315
GO:0030018
GO:0005509
GO:0004198
GO:0003824
GO:0055103
GO:0008233
GO:0032947
GO:0031402
GO:0008307
GO:0031432
GO:0071277
GO:0071472
GO:0061061
GO:0030239
GO:0043066
GO:0033234
GO:0045892
GO:0051092
GO:0045862
GO:0051281
GO:0014718
GO:0045893
GO:0006461
GO:0072657
GO:0006508
GO:0050790
GO:0043122
GO:0051592
GO:0014850
GO:0045214
GO:0097264
Gene3D 1.10.238.10
InterPro IPR022684
IPR022682
IPR022683
IPR029531
IPR011992
IPR018247
IPR002048
IPR000169
IPR001300
PANTHER PTHR10183:SF49
Pfam PF01067
PF00036
PF13405
PF00648
PRINTS PR00704
SMART SM00720
SM00230
SM00054
SUPFAM SSF49758
PROSITE PS50203
PS00018
PS50222
PS00139

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1990092

calcium-dependent self proteolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

P

Seeded From UniProt

complete

involved_in

GO:0097264

self proteolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

P

Seeded From UniProt

complete

involved_in

GO:0072657

protein localization to membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

involved_in

GO:0071472

cellular response to salt stress

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

involved_in

GO:0071277

cellular response to calcium ion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

involved_in

GO:0061061

muscle structure development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

enables

GO:0055103

ligase regulator activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

F

Seeded From UniProt

complete

involved_in

GO:0051592

response to calcium ion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

P

Seeded From UniProt

complete

involved_in

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

P

Seeded From UniProt

complete

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

involved_in

GO:0045862

positive regulation of proteolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

involved_in

GO:0045214

sarcomere organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

C

Seeded From UniProt

complete

involved_in

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

involved_in

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

P

Seeded From UniProt

complete

involved_in

GO:0033234

negative regulation of protein sumoylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

P

Seeded From UniProt

complete

enables

GO:0032947

protein-containing complex scaffold activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

F

Seeded From UniProt

complete

enables

GO:0031432

titin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

F

Seeded From UniProt

complete

enables

GO:0031402

sodium ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

F

Seeded From UniProt

complete

part_of

GO:0030315

T-tubule

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

C

Seeded From UniProt

complete

involved_in

GO:0030239

myofibril assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

part_of

GO:0030018

Z disc

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

C

Seeded From UniProt

complete

part_of

GO:0030016

myofibril

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

C

Seeded From UniProt

complete

involved_in

GO:0014850

response to muscle activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

P

Seeded From UniProt

complete

involved_in

GO:0014718

positive regulation of satellite cell activation involved in skeletal muscle regeneration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

enables

GO:0008307

structural constituent of muscle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

P

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

F

Seeded From UniProt

complete

enables

GO:0004198

calcium-dependent cysteine-type endopeptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q64691

F

Seeded From UniProt

complete

enables

GO:0004198

calcium-dependent cysteine-type endopeptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16259

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20807

F

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107437
PANTHER:PTN000021935
UniProtKB:P20807

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0012051
FB:FBgn0025866
MGI:MGI:107437
MGI:MGI:88263
MGI:MGI:88264
PANTHER:PTN000021568
RGD:2267
RGD:2268
RGD:2269
RGD:69354
UniProtKB:P07384
UniProtKB:P20807
UniProtKB:P35750
UniProtKB:Q9HC96
WB:WBGene00006606

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025866
FB:FBgn0260450
MGI:MGI:107437
MGI:MGI:88264
PANTHER:PTN000021568
RGD:2268
RGD:2269
RGD:69354
UniProtKB:P20807
UniProtKB:P35750
UniProtKB:Q8RVL2

C

Seeded From UniProt

complete

enables

GO:0004198

calcium-dependent cysteine-type endopeptidase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0012051
FB:FBgn0025866
MGI:MGI:107437
MGI:MGI:2181366
MGI:MGI:88263
PANTHER:PTN000021568
RGD:2267
RGD:2269
RGD:69354
UniProtKB:P07384
UniProtKB:P17655
UniProtKB:P35750
UniProtKB:Q9HC96

F

Seeded From UniProt

complete

enables

GO:0004198

calcium-dependent cysteine-type endopeptidase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0012051
FB:FBgn0025866
MGI:MGI:107437
MGI:MGI:2181366
MGI:MGI:88263
MGI:MGI:88264
PANTHER:PTN000021568
RGD:2267
RGD:2268
RGD:2269
RGD:69354
UniProtKB:P07384
UniProtKB:P17655
UniProtKB:P35750
UniProtKB:Q9HC96

F

Seeded From UniProt

complete

enables

GO:0004198

calcium-dependent cysteine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001300
InterPro:IPR022684
InterPro:IPR029531

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002048

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001300
InterPro:IPR022684
InterPro:IPR029531

P

Seeded From UniProt

complete

involved_in

GO:0045214

sarcomere organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029531

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page