CHICK:B2CL1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	BCL2L1 (synonyms: BCL-X, BCLX)
Protein Name(s)	Bcl-2-like protein 1 Bcl2-L-1 Apoptosis regulator Bcl-X
External Links
UniProt	Q07816
EMBL	Z23110 U26645
PIR	A47537
RefSeq	NP_001020475.1
UniGene	Gga.4944
ProteinModelPortal	Q07816
SMR	Q07816
STRING	9031.ENSGALP00000010059
PaxDb	Q07816
Ensembl	ENSGALT00000010026 ENSGALT00000010073
GeneID	373954
KEGG	gga:373954
CTD	598
eggNOG	NOG300479
GeneTree	ENSGT00530000062935
HOGENOM	HOG000056452
InParanoid	Q07816
KO	K04570
OMA	NGSPSWH
PhylomeDB	Q07816
TreeFam	TF315834
Reactome	REACT_277432
NextBio	20813485
PRO	PR:Q07816
Proteomes	UP000000539
ExpressionAtlas	Q07816
GO	GO:0097136 GO:0030054 GO:0005813 GO:0005829 GO:0016021 GO:0005759 GO:0005741 GO:0031965 GO:0005730 GO:0030672 GO:0046982 GO:0042803 GO:0071839 GO:0008283 GO:0060154 GO:0071312 GO:0071230 GO:0071480 GO:0000910 GO:0097192 GO:0009566 GO:0007281 GO:0040007 GO:0097284 GO:0008630 GO:0008584 GO:0070584 GO:0007093 GO:2000811 GO:0090005 GO:1900118 GO:2001243 GO:1902230 GO:0043524 GO:0090201 GO:0051402 GO:0001541 GO:0043065 GO:0008284 GO:0046902 GO:0051881 GO:0001836 GO:0046898 GO:0034097 GO:0007283 GO:0019050
InterPro	IPR013279 IPR002475 IPR004725 IPR020717 IPR020726 IPR020728 IPR003093 IPR020731 IPR026298
PANTHER	PTHR11256 PTHR11256:SF12
Pfam	PF00452 PF02180
PRINTS	PR01864 PR01862
TIGRFAMs	TIGR00865
PROSITE	PS50062 PS01080 PS01258 PS01259 PS01260 PS50063

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0007093	mitotic cell cycle checkpoint	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q07817	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q07817	C	Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q07817	P	Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135647 UniProtKB:P10415 UniProtKB:Q07817 ZFIN:ZDB-GENE-010730-1	P	Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:108052 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 UniProtKB:Q07820	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2199 RGD:2200 RGD:620525 RGD:620621 RGD:620717 RGD:621635 RGD:70984 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q07820 UniProtKB:Q16611 UniProtKB:Q92843 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-030825-1 ZFIN:ZDB-GENE-051012-1	F	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:102687 MGI:MGI:88138 MGI:MGI:88139 PANTHER:PTN000135647 RGD:2199 RGD:2200 RGD:620525 UniProtKB:P10415 UniProtKB:Q07817 UniProtKB:Q07820 UniProtKB:Q92843 WB:WBGene00000423 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-010730-1	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1330841 MGI:MGI:1858494 MGI:MGI:99702 PANTHER:PTN000135648 RGD:621635 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q16611	F	Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029131 MGI:MGI:101769 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648	P	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2200 UniProtKB:P10415 UniProtKB:Q07817 WB:WBGene00000423	C	Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
involved_in	GO:1903077	negative regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
involved_in	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
involved_in	GO:1900118	negative regulation of execution phase of apoptosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
part_of	GO:0097136	Bcl-2 family protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	C	Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
enables	GO:0051434	BH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	F	Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	F	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	F	Seeded From UniProt	complete
involved_in	GO:0019050	suppression by virus of host apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
involved_in	GO:0007093	mitotic cell cycle checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	C	Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000302564	P	Seeded From UniProt	complete
involved_in	GO:0097284	hepatocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0071839	apoptotic process in bone marrow cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0071312	cellular response to alkaloid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0070584	mitochondrion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0060154	cellular process regulating host cell cycle in response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	F	Seeded From UniProt	complete
involved_in	GO:0046898	response to cycloheximide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	C	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0009566	fertilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	C	Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64373 ensembl:ENSMUSP00000105445	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004725	C	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003093 InterPro:IPR004725 InterPro:IPR013279 InterPro:IPR020717 InterPro:IPR020726 InterPro:IPR020728 InterPro:IPR020731 InterPro:IPR026298 InterPro:IPR036834	P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0260	C	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C	Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:B2CL1

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