It is now the 1st OPEN Period for CACAO Fall 2017! It will end on Sunday September 24, 2017 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

CHICK:A3R0S3

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) GRB2 (ECO:0000313 with Ensembl:ENSGALP00000012993)
Protein Name(s) Growth factor receptor-bound protein 2 (ECO:0000313 with EMBL:ABM91436.1, ECO:0000313 with Ensembl:ENSGALP00000012993)
External Links
UniProt A3R0S3
EMBL AADN03007560
EF062570
UniGene Gga.41897
SMR A3R0S3
STRING 9031.ENSGALP00000012993
Ensembl ENSGALT00000013008
GeneTree ENSGT00550000074482
HOVERGEN HBG005404
OMA RFQDSVQ
OrthoDB EOG75F4F6
TreeFam TF354288
Reactome REACT_189747
REACT_189751
REACT_189761
REACT_194391
REACT_194392
REACT_194393
REACT_194397
REACT_194410
REACT_196285
REACT_196766
REACT_196849
REACT_196855
REACT_197116
REACT_197153
REACT_197520
REACT_197606
REACT_198076
REACT_198138
REACT_198215
REACT_207556
REACT_216353
REACT_217737
REACT_230602
REACT_231139
REACT_239556
REACT_239808
REACT_240004
REACT_242651
REACT_244511
REACT_244793
REACT_244921
REACT_246488
REACT_246525
REACT_247307
REACT_251572
REACT_251680
REACT_260570
REACT_260993
REACT_262266
REACT_94545
Proteomes UP000000539
GO GO:0005911
GO:0008180
GO:0005768
GO:0070062
GO:0070436
GO:0012506
GO:0044822
GO:0048646
GO:0030154
GO:0071479
GO:0008286
GO:0030838
GO:2000379
GO:0009967
GO:0031623
GO:0043408
GO:0042770
Gene3D 3.30.505.10
InterPro IPR030219
IPR000980
IPR001452
PANTHER PTHR22820:SF27
Pfam PF00017
PF00018
PRINTS PR00401
PR00452
SMART SM00252
SM00326
SUPFAM SSF50044
SSF55550
PROSITE PS50001
PS50002

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004872

receptor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0675

F

complete

GO:0005070

SH3/SH2 adaptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

F

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

C

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

P

complete

GO:0012506

vesicle membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

C

complete

GO:0016020

membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

C

complete

GO:0019904

protein domain specific binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

F

complete

GO:0030154

cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

P

complete

GO:0043408

regulation of MAPKKK cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

P

complete

GO:0048646

anatomical structure formation involved in morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

P

complete

GO:0060670

branching involved in embryonic placenta morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

P

complete

GO:0005070

SH3/SH2 adaptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR030219

F

Seeded From UniProt

complete

GO:0005070

SH3/SH2 adaptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

F

Seeded From UniProt

complete

GO:0005154

epidermal growth factor receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

F

Seeded From UniProt

complete

GO:0005168

neurotrophin TRKA receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

C

Seeded From UniProt

complete

GO:0005730

nucleolus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

C

Seeded From UniProt

complete

GO:0005768

endosome

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

C

Seeded From UniProt

complete

GO:0005911

cell-cell junction

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

C

Seeded From UniProt

complete

GO:0007265

Ras protein signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR030219

P

Seeded From UniProt

complete

GO:0008180

COP9 signalosome

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

C

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

P

Seeded From UniProt

complete

GO:0009967

positive regulation of signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR030219

P

Seeded From UniProt

complete

GO:0009967

positive regulation of signal transduction

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

P

Seeded From UniProt

complete

GO:0012506

vesicle membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR030219

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

C

Seeded From UniProt

complete

GO:0017124

SH3 domain binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

F

Seeded From UniProt

complete

GO:0019901

protein kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

F

Seeded From UniProt

complete

GO:0019903

protein phosphatase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

F

Seeded From UniProt

complete

GO:0019904

protein domain specific binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

F

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

P

Seeded From UniProt

complete

GO:0030838

positive regulation of actin filament polymerization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

P

Seeded From UniProt

complete

GO:0031623

receptor internalization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

P

Seeded From UniProt

complete

GO:0042770

signal transduction in response to DNA damage

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

P

Seeded From UniProt

complete

GO:0042802

identical protein binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

F

Seeded From UniProt

complete

GO:0043408

regulation of MAPK cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

P

Seeded From UniProt

complete

GO:0043560

insulin receptor substrate binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

F

Seeded From UniProt

complete

GO:0044822

poly(A) RNA binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

F

Seeded From UniProt

complete

GO:0046875

ephrin receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

F

Seeded From UniProt

complete

GO:0048646

anatomical structure formation involved in morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000021090

P

Seeded From UniProt

complete

GO:0070062

extracellular exosome

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

C

Seeded From UniProt

complete

GO:0070436

Grb2-EGFR complex

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

C

Seeded From UniProt

complete

GO:0071479

cellular response to ionizing radiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

P

Seeded From UniProt

complete

GO:2000379

positive regulation of reactive oxygen species metabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000376345

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.