CHICK:A3DTN6

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	IL8 (ECO:0000313 with EMBL:ACR08238.1)
Protein Name(s)	C-X-C motif chemokine (ECO:0000256 with RuleBase:RU361149)
External Links
UniProt	A3DTN6
EMBL	DQ393272 FJ907843 FJ907844 FJ907845 FJ907846 FJ907847 FJ907848 FJ907849 FJ907850 FJ907851 FJ907852 FJ907853 FJ907854 FJ907855 FJ907856 FJ907857 FJ907858 FJ907859 FJ907860 FJ907865 FJ907866 FJ907867 FJ907868 FJ907869 FJ907870 FJ907871 FJ907872 FJ907873 FJ907874 FJ907875 FJ907876 FJ907877 FJ907878 FJ907879 FJ907880 FJ907881 FJ907882 HM179639 HQ008779
RefSeq	NP_990829.1
UniGene	Gga.826
ProteinModelPortal	A3DTN6
GeneID	396495
KEGG	gga:396495
CTD	396495
HOVERGEN	HBG107789
KO	K10030
OMA	CEAAVLT
PhylomeDB	A3DTN6
NextBio	20816534
GO	GO:0005615 GO:0006955 GO:0042119 GO:0030593
InterPro	IPR001089 IPR018048 IPR001811 IPR028469
PANTHER	PTHR10179 PTHR10179:SF35
Pfam	PF00048
PRINTS	PR00437
SMART	SM00199
SUPFAM	SSF54117
PROSITE	PS00471

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0042742	defense response to bacterium	PMID:17540517^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:9878121^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0005335)	Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	PMID:9878121^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0005335)	Seeded From UniProt	complete
involved_in	GO:0048247	lymphocyte chemotaxis	PMID:9878121^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0005335)	Seeded From UniProt	complete
involved_in	GO:0048246	macrophage chemotaxis	PMID:9878121^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0005335)	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:11781340^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036446	myofibroblast differentiation	PMID:11781340^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048147	negative regulation of fibroblast proliferation	PMID:11781340^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
enables	GO:0005153	interleukin-8 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028469	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR028469 InterPro:IPR036048	C		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033899	P		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033899	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR036048	P		Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR028469 InterPro:IPR033899 InterPro:IPR036048	F		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028469	P		Seeded From UniProt	complete
involved_in	GO:0042119	neutrophil activation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028469	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000083251	C		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:16762413^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	PMID:16762413^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042119	neutrophil activation	PMID:17540517^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:17540517^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010186	positive regulation of cellular defense response	PMID:17540517^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Borrmann, E et al. (2007) Campylobacter-induced interleukin-8 responses in human intestinal epithelial cells and primary intestinal chick cells. Vet. Microbiol. 124 115-24 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Martins-Green, M & Kelly, T (1998) The chicken chemotactic and angiogenic factor (9E3 gene product): its angiogenic properties reside in the C-terminus of the molecule. Cytokine 10 819-30 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Feugate, JE et al. (2002) The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. J. Cell Biol. 156 161-72 PubMed GONUTS page
↑ ^4.0 ^4.1 Cheeseman, JH et al. (2007) Breed effect on early cytokine mRNA expression in spleen and cecum of chickens with and without Salmonella enteritidis infection. Dev. Comp. Immunol. 31 52-60 PubMed GONUTS page

[PMID:17540517-1] 1.0 ^1.1 ^1.2 ^1.3 Borrmann, E et al. (2007) Campylobacter-induced interleukin-8 responses in human intestinal epithelial cells and primary intestinal chick cells. Vet. Microbiol. 124 115-24 PubMed GONUTS page

[PMID:9878121-2] 2.0 ^2.1 ^2.2 ^2.3 Martins-Green, M & Kelly, T (1998) The chicken chemotactic and angiogenic factor (9E3 gene product): its angiogenic properties reside in the C-terminus of the molecule. Cytokine 10 819-30 PubMed GONUTS page

[PMID:11781340-3] 3.0 ^3.1 ^3.2 Feugate, JE et al. (2002) The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. J. Cell Biol. 156 161-72 PubMed GONUTS page

[PMID:16762413-4] 4.0 ^4.1 Cheeseman, JH et al. (2007) Breed effect on early cytokine mRNA expression in spleen and cecum of chickens with and without Salmonella enteritidis infection. Dev. Comp. Immunol. 31 52-60 PubMed GONUTS page

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CHICK:A3DTN6

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