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CAEEL:KINH

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) unc-116 (synonyms: khc-1)
Protein Name(s) Kinesin heavy chain

Uncoordinated protein 116 Protein unc-116

External Links
UniProt P34540
EMBL AB017163
L19120
FO081667
PIR S44868
RefSeq NP_498842.1
UniGene Cel.37531
ProteinModelPortal P34540
SMR P34540
BioGrid 41383
IntAct P34540
MINT MINT-1114807
STRING 6239.R05D3.7
PaxDb P34540
PRIDE P34540
EnsemblMetazoa R05D3.7
GeneID 176179
KEGG cel:CELE_R05D3.7
UCSC R05D3.7
CTD 176179
WormBase R05D3.7
eggNOG COG5059
GeneTree ENSGT00770000120453
HOGENOM HOG000216718
InParanoid P34540
KO K10396
OMA GTMRENE
PhylomeDB P34540
Reactome REACT_183300
NextBio 891464
Proteomes UP000001940
GO GO:0005737
GO:0016938
GO:0005874
GO:0043005
GO:0005635
GO:0045202
GO:0005524
GO:0016887
GO:0008574
GO:0006200
GO:0007411
GO:0030705
GO:0009792
GO:0051295
GO:0051296
GO:0040011
GO:0033206
GO:0008152
GO:0007018
GO:0040038
GO:0010940
GO:0008104
GO:0048814
GO:0048489
Gene3D 3.40.850.10
InterPro IPR027640
IPR019821
IPR001752
IPR027417
PANTHER PTHR24115
Pfam PF00225
PRINTS PR00380
SMART SM00129
SUPFAM SSF52540
PROSITE PS00411
PS50067

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0003777

microtubule motor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001752
InterPro:IPR019821
InterPro:IPR027640

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001752
InterPro:IPR019821

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005635

nuclear envelope

PMID:19605495[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:19605495[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

GO:0030951

establishment or maintenance of microtubule cytoskeleton polarity

PMID:23482306[2]

IMP: Inferred from Mutant Phenotype

P

Figure 1.

complete
CACAO 8311

GO:0005871

kinesin complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027640

C

Seeded From UniProt

complete

GO:0005874

microtubule

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

GO:0007018

microtubule-based movement

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001752
InterPro:IPR019821
InterPro:IPR027640

P

Seeded From UniProt

complete

GO:0007018

microtubule-based movement

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000648413

P

Seeded From UniProt

complete

GO:0007411

axon guidance

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001189978

P

Seeded From UniProt

complete

GO:0008017

microtubule binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001752

F

Seeded From UniProt

complete

GO:0008104

protein localization

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000648414

P

Seeded From UniProt

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001752
InterPro:IPR019821
InterPro:IPR027640

P

Seeded From UniProt

complete

GO:0008574

ATP-dependent microtubule motor activity, plus-end-directed

PMID:21569846[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0009792

embryo development ending in birth or egg hatching

PMID:15883196[4]

IMP: Inferred from Mutant Phenotype

WB:WBVar00241507

P

Seeded From UniProt

complete

GO:0010940

positive regulation of necrotic cell death

PMID:22157748[5]

IGI: Inferred from Genetic Interaction

WB:WBGene00000278
WB:WBGene00003168

P

Seeded From UniProt

complete

GO:0010940

positive regulation of necrotic cell death

PMID:22157748[5]

IGI: Inferred from Genetic Interaction

WB:WBGene00000951

P

Seeded From UniProt

complete

GO:0010940

positive regulation of necrotic cell death

PMID:22157748[5]

IGI: Inferred from Genetic Interaction

WB:WBGene00003168

P

Seeded From UniProt

complete

GO:0016938

kinesin I complex

PMID:15563606[6]

IPI: Inferred from Physical Interaction

WB:WBGene00002215

C

Seeded From UniProt

complete

GO:0030705

cytoskeleton-dependent intracellular transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000648414

P

Seeded From UniProt

complete

GO:0030951

establishment or maintenance of microtubule cytoskeleton polarity

PMID:23482306[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0033206

meiotic cytokinesis

PMID:15883196[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040011

locomotion

PMID:15883196[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040038

polar body extrusion after meiotic divisions

PMID:15883196[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043005

neuron projection

PMID:24360545[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045202

synapse

PMID:24360545[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0048489

synaptic vesicle transport

PMID:15563606[6]

IMP: Inferred from Mutant Phenotype

WB:WBVar00144701

P

Seeded From UniProt

complete

GO:0048814

regulation of dendrite morphogenesis

PMID:21205795[8]

IGI: Inferred from Genetic Interaction

WB:WBGene00016611

P

Seeded From UniProt

complete

GO:0048814

regulation of dendrite morphogenesis

PMID:21205795[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051295

establishment of meiotic spindle localization

PMID:15883196[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051296

establishment of meiotic spindle orientation

PMID:15883196[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Meyerzon, M et al. (2009) UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration. Development 136 2725-33 PubMed GONUTS page
  2. 2.0 2.1 Yan, J et al. (2013) Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans. Elife 2 e00133 PubMed GONUTS page
  3. Tien, NW et al. (2011) Tau/PTL-1 associates with kinesin-3 KIF1A/UNC-104 and affects the motor's motility characteristics in C. elegans neurons. Neurobiol. Dis. 43 495-506 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Yang, HY et al. (2005) Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter. J. Cell Biol. 169 447-57 PubMed GONUTS page
  5. 5.0 5.1 5.2 Troulinaki, K & Tavernarakis, N (2012) Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J. 31 654-66 PubMed GONUTS page
  6. 6.0 6.1 Sakamoto, R et al. (2005) The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization. Mol. Biol. Cell 16 483-96 PubMed GONUTS page
  7. 7.0 7.1 Hoerndli, FJ et al. (2013) Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors. Neuron 80 1421-37 PubMed GONUTS page
  8. 8.0 8.1 Aguirre-Chen, C et al. (2011) C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development 138 507-18 PubMed GONUTS page