CAEEL:KINH

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	unc-116 (synonyms: khc-1)
Protein Name(s)	Kinesin heavy chain Uncoordinated protein 116 Protein unc-116
External Links
UniProt	P34540
EMBL	AB017163 L19120 FO081667
PIR	S44868
RefSeq	NP_498842.1
UniGene	Cel.37531
ProteinModelPortal	P34540
SMR	P34540
BioGrid	41383
IntAct	P34540
MINT	MINT-1114807
STRING	6239.R05D3.7
PaxDb	P34540
PRIDE	P34540
EnsemblMetazoa	R05D3.7
GeneID	176179
KEGG	cel:CELE_R05D3.7
UCSC	R05D3.7
CTD	176179
WormBase	R05D3.7
eggNOG	COG5059
GeneTree	ENSGT00770000120453
HOGENOM	HOG000216718
InParanoid	P34540
KO	K10396
OMA	GTMRENE
PhylomeDB	P34540
Reactome	REACT_183300
NextBio	891464
Proteomes	UP000001940
GO	GO:0005737 GO:0016938 GO:0005874 GO:0043005 GO:0005635 GO:0045202 GO:0005524 GO:0016887 GO:0008574 GO:0006200 GO:0007411 GO:0030705 GO:0009792 GO:0051295 GO:0051296 GO:0040011 GO:0033206 GO:0008152 GO:0007018 GO:0040038 GO:0010940 GO:0008104 GO:0048814 GO:0048489
Gene3D	3.40.850.10
InterPro	IPR027640 IPR019821 IPR001752 IPR027417
PANTHER	PTHR24115
Pfam	PF00225
PRINTS	PR00380
SMART	SM00129
SUPFAM	SSF52540
PROSITE	PS00411 PS50067

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	PMID:23482306^[1]	ECO:0000315			P	Figure 1.	complete CACAO 8311
involved_in	GO:0030473	nuclear migration along microtubule	PMID:19605495^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	PMID:23482306^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:21205795^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00016611	P	Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:21205795^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051296	establishment of meiotic spindle orientation	PMID:15883196^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051295	establishment of meiotic spindle localization	PMID:15883196^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	PMID:15563606^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00144701	P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:24360545^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:24360545^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0040038	polar body extrusion after meiotic divisions	PMID:15883196^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0040011	locomotion	PMID:15883196^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033206	meiotic cytokinesis	PMID:15883196^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016938	kinesin I complex	PMID:15563606^[5]	ECO:0000353	physical interaction evidence used in manual assertion	WB:WBGene00002215	C	Seeded From UniProt	complete
involved_in	GO:0010940	positive regulation of necrotic cell death	PMID:22157748^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000278 WB:WBGene00003168	P	Seeded From UniProt	complete
involved_in	GO:0010940	positive regulation of necrotic cell death	PMID:22157748^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00003168	P	Seeded From UniProt	complete
involved_in	GO:0010940	positive regulation of necrotic cell death	PMID:22157748^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000951	P	Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	PMID:15883196^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00241507	P	Seeded From UniProt	complete
enables	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	PMID:21569846^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19605495^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:19605495^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0098971	anterograde dendritic transport of neurotransmitter receptor complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109564 PANTHER:PTN000648417	P	Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 PANTHER:PTN000648417 WB:WBGene00006840	P	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108426 MGI:MGI:1098226 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPBC1604.20c PomBase:SPBC1685.15c PomBase:SPBC2F12.13 RGD:621520 TAIR:locus:2148543 TAIR:locus:2157533 UniProtKB:C8V3Q8 UniProtKB:Q0IMS9 UniProtKB:Q6YZ52 UniProtKB:Q7X7H4 UniProtKB:Q96Q89 dictyBase:DDB_G0280967	F	Seeded From UniProt	complete
enables	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000648414 WB:WBGene00006840 dictyBase:DDB_G0281555	F	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000352 FB:FBgn0001308 FB:FBgn0004378 FB:FBgn0011606 MGI:MGI:107689 MGI:MGI:108391 MGI:MGI:109564 MGI:MGI:1098226 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPAC3A11.14c PomBase:SPAC664.10 PomBase:SPBC1604.20c PomBase:SPBC1685.15c PomBase:SPBC2F12.13 RGD:1304996 RGD:1306815 RGD:621538 RGD:621559 SGD:S000006345 TAIR:locus:2129630 TAIR:locus:2136437 TAIR:locus:2148543 TAIR:locus:2157533 UniProtKB:O00139 UniProtKB:P17120 UniProtKB:P33176 UniProtKB:Q02224 UniProtKB:Q02241 UniProtKB:Q0IMS9 UniProtKB:Q8NI77 UniProtKB:Q96Q89 WB:WBGene00006831 WB:WBGene00006974 dictyBase:DDB_G0276369	F	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 PANTHER:PTN001189978	P	Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0004378 FB:FBgn0004381 MGI:MGI:108426 MGI:MGI:2447072 PANTHER:PTN000648413 UniProtKB:Q0IMS9 UniProtKB:Q6YZ52 UniProtKB:Q7X7H4 WB:WBGene00002222 WB:WBGene00002225 WB:WBGene00002230 WB:WBGene00006831 WB:WBGene00006974 dictyBase:DDB_G0281555	P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004378 PANTHER:PTN000648413 RGD:1303035 RGD:1304996 RGD:621538 TAIR:locus:2089358 UniProtKB:O00139 UniProtKB:P52732 UniProtKB:Q02224 UniProtKB:Q15058 UniProtKB:Q9HAQ2 WB:WBGene00002228 WB:WBGene00003884 ZFIN:ZDB-GENE-991019-4	C	Seeded From UniProt	complete
part_of	GO:0005871	kinesin complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0002948 FB:FBgn0004378 MGI:MGI:109202 MGI:MGI:1098229 PANTHER:PTN000648413 RGD:1303035 UniProtKB:D6XFK9 UniProtKB:O77382 UniProtKB:Q57UW8 UniProtKB:Q57X99 UniProtKB:Q582I0 WB:WBGene00003884	C	Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0002948 FB:FBgn0003545 MGI:MGI:108426 MGI:MGI:1098229 MGI:MGI:1098264 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPAC3A11.14c RGD:621559 SGD:S000000159 SGD:S000000787 TAIR:locus:2115713 UniProtKB:A0A0B4KFR5 UniProtKB:A0A1D8PT88 UniProtKB:O77382 UniProtKB:P17120 UniProtKB:P33176 UniProtKB:Q02224 UniProtKB:Q0IMS9 UniProtKB:Q2M1P5 UniProtKB:Q5T7B8 UniProtKB:Q6YZ52 WB:WBGene00002222 WB:WBGene00002230 WB:WBGene00003884 WB:WBGene00006974 dictyBase:DDB_G0280967 dictyBase:DDB_G0291039	F	Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098971	C	Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821 InterPro:IPR027640	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821	F	Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821 InterPro:IPR027640	P	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752	F	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yan, J et al. (2013) Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans. Elife 2 e00133 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Meyerzon, M et al. (2009) UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration. Development 136 2725-33 PubMed GONUTS page
↑ ^3.0 ^3.1 Aguirre-Chen, C et al. (2011) C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development 138 507-18 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Yang, HY et al. (2005) Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter. J. Cell Biol. 169 447-57 PubMed GONUTS page
↑ ^5.0 ^5.1 Sakamoto, R et al. (2005) The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization. Mol. Biol. Cell 16 483-96 PubMed GONUTS page
↑ ^6.0 ^6.1 Hoerndli, FJ et al. (2013) Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors. Neuron 80 1421-37 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Troulinaki, K & Tavernarakis, N (2012) Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J. 31 654-66 PubMed GONUTS page
↑ Tien, NW et al. (2011) Tau/PTL-1 associates with kinesin-3 KIF1A/UNC-104 and affects the motor's motility characteristics in C. elegans neurons. Neurobiol. Dis. 43 495-506 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 ^9.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23482306-1] 1.0 ^1.1 Yan, J et al. (2013) Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans. Elife 2 e00133 PubMed GONUTS page

[PMID:19605495-2] 2.0 ^2.1 ^2.2 Meyerzon, M et al. (2009) UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration. Development 136 2725-33 PubMed GONUTS page

[PMID:21205795-3] 3.0 ^3.1 Aguirre-Chen, C et al. (2011) C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development 138 507-18 PubMed GONUTS page

[PMID:15883196-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Yang, HY et al. (2005) Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter. J. Cell Biol. 169 447-57 PubMed GONUTS page

[PMID:15563606-5] 5.0 ^5.1 Sakamoto, R et al. (2005) The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization. Mol. Biol. Cell 16 483-96 PubMed GONUTS page

[PMID:24360545-6] 6.0 ^6.1 Hoerndli, FJ et al. (2013) Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors. Neuron 80 1421-37 PubMed GONUTS page

[PMID:22157748-7] 7.0 ^7.1 ^7.2 Troulinaki, K & Tavernarakis, N (2012) Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J. 31 654-66 PubMed GONUTS page

[PMID:21569846-8] Tien, NW et al. (2011) Tau/PTL-1 associates with kinesin-3 KIF1A/UNC-104 and affects the motor's motility characteristics in C. elegans neurons. Neurobiol. Dis. 43 495-506 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 ^9.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

CAEEL:KINH

Contents

Annotations

Notes

References

a

c

d

e

k

l

m

n

o

p

r

s

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools