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CAEEL:IRE1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) ire-1
Protein Name(s) Serine/threonine-protein kinase/endoribonuclease ire-1

Inositol-requiring protein 2 Serine/threonine-protein kinase Endoribonuclease

External Links
UniProt Q09499
EMBL AF435952
Z48045
PIR T19874
RefSeq NP_001254135.1
UniGene Cel.24223
ProteinModelPortal Q09499
SMR Q09499
STRING 6239.C41C4.4
PaxDb Q09499
EnsemblMetazoa C41C4.4a
GeneID 174305
KEGG cel:CELE_C41C4.4
UCSC C41C4.4
CTD 174305
WormBase C41C4.4a
eggNOG COG0515
GeneTree ENSGT00390000015684
HOGENOM HOG000012929
InParanoid Q09499
KO K08852
OMA YVWQREG
PhylomeDB Q09499
Reactome REACT_253408
SignaLink Q09499
NextBio 883446
PRO PR:Q09499
Proteomes UP000001940
ExpressionAtlas Q09499
GO GO:0030176
GO:0005524
GO:0004521
GO:0004674
GO:0030968
GO:0002119
GO:0090305
GO:1902255
GO:0006990
GO:0006468
GO:0035966
GO:0090502
GO:0030969
Gene3D 2.140.10.10
InterPro IPR010513
IPR011009
IPR018391
IPR002372
IPR000719
IPR006567
IPR027295
IPR011047
IPR008271
Pfam PF00069
PF01011
PF06479
SMART SM00564
SM00580
SUPFAM SSF50998
SSF56112
PROSITE PS51392
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

PMID:19822669[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:20733002[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

happens_during:(GO:1904576)

Seeded From UniProt

complete

involved_in

GO:1904576

response to tunicamycin

PMID:20733002[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902255

positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

PMID:25340700[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

PMID:11779465[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75460

P

Seeded From UniProt

complete

involved_in

GO:0035966

response to topologically incorrect protein

PMID:23335331[5]

ECO:0000316

genetic interaction evidence used in manual assertion

WB:WBGene00002004

P

Seeded From UniProt

complete

involved_in

GO:0035966

response to topologically incorrect protein

PMID:23335331[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

WB:WBVar00274962

P

Seeded From UniProt

complete

involved_in

GO:0030968

endoplasmic reticulum unfolded protein response

PMID:11779465[4]

ECO:0000316

genetic interaction evidence used in manual assertion

WB:WBGene00003970

P

Seeded From UniProt

complete

involved_in

GO:0030968

endoplasmic reticulum unfolded protein response

PMID:11780124[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

WB:WBVar00275456

P

Seeded From UniProt

complete

involved_in

GO:0030968

endoplasmic reticulum unfolded protein response

PMID:11779465[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

WB:WBVar00274962

P

Seeded From UniProt

complete

part_of

GO:0030176

integral component of endoplasmic reticulum membrane

PMID:11779465[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75460

C

Seeded From UniProt

complete

involved_in

GO:0006990

positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

PMID:18216284[7]

ECO:0000316

genetic interaction evidence used in manual assertion

WB:WBGene00017244

P

has_regulation_target:(WB:WBGene00002008)

Seeded From UniProt

complete

involved_in

GO:0006990

positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

PMID:18216284[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(WB:WBGene00017244)

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:11779465[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75460

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:11779465[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75460

F

Seeded From UniProt

complete

enables

GO:0004521

endoribonuclease activity

PMID:11779465[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75460

F

Seeded From UniProt

complete

involved_in

GO:0002119

nematode larval development

PMID:11779465[4]

ECO:0000316

genetic interaction evidence used in manual assertion

WB:WBGene00003970

P

Seeded From UniProt

complete

part_of

GO:1990604

IRE1-TRAF2-ASK1 complex

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1349436
PANTHER:PTN000359335
UniProtKB:O75460

C

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1349436
MGI:MGI:1930134
PANTHER:PTN000359335

P

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000359335
SGD:S000001121

F

Seeded From UniProt

complete

involved_in

GO:0036498

IRE1-mediated unfolded protein response

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261984
MGI:MGI:1930134
PANTHER:PTN000359335
PomBase:SPAC167.01
UniProtKB:O75460

P

Seeded From UniProt

complete

involved_in

GO:0030968

endoplasmic reticulum unfolded protein response

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261984
MGI:MGI:1930134
PANTHER:PTN000359335
PomBase:SPAC167.01
SGD:S000001121
TAIR:locus:2053928
UniProtKB:O75460
UniProtKB:Q4WKP8
UniProtKB:Q93VJ2
WB:WBGene00002147

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1349436
MGI:MGI:1930134
PANTHER:PTN000359335
SGD:S000001121
TAIR:locus:2053928
UniProtKB:O75460
UniProtKB:Q7XIT1

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1930134
PANTHER:PTN000359335
SGD:S000001121
UniProtKB:O75460
UniProtKB:Q76MJ5

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1930134
PANTHER:PTN000359335
SGD:S000001121
UniProtKB:O75460
UniProtKB:Q76MJ5

F

Seeded From UniProt

complete

enables

GO:0004521

endoribonuclease activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261984
MGI:MGI:1930134
PANTHER:PTN000359335
PomBase:SPAC167.01
SGD:S000001121
TAIR:locus:2053928
UniProtKB:O75460
UniProtKB:Q4WKP8
UniProtKB:Q93VJ2

F

Seeded From UniProt

complete

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004540

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004521

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004521

P

Seeded From UniProt

complete

enables

GO:0004540

ribonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010513

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010513

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

involved_in

GO:0006986

response to unfolded protein

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0834

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Lim, PJ et al. (2009) Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J. Cell Biol. 187 201-17 PubMed GONUTS page
  2. ↑ 2.0 2.1 Mao, XR & Crowder, CM (2010) Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery. Mol. Cell. Biol. 30 5033-42 PubMed GONUTS page
  3. ↑ Levi-Ferber, M et al. (2014) It's all in your mind: determining germ cell fate by neuronal IRE-1 in C. elegans. PLoS Genet. 10 e1004747 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Shen, X et al. (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107 893-903 PubMed GONUTS page
  5. ↑ 5.0 5.1 Schipanski, A et al. (2013) A novel interaction between aging and ER overload in a protein conformational dementia. Genetics 193 865-76 PubMed GONUTS page
  6. ↑ Calfon, M et al. (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415 92-6 PubMed GONUTS page
  7. ↑ 7.0 7.1 Uccelletti, D et al. (2008) APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses. Mol. Biol. Cell 19 1337-45 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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