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CAEEL:IRE1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) ire-1
Protein Name(s) Serine/threonine-protein kinase/endoribonuclease ire-1

Inositol-requiring protein 2 Serine/threonine-protein kinase Endoribonuclease

External Links
UniProt Q09499
EMBL AF435952
Z48045
PIR T19874
RefSeq NP_001254135.1
UniGene Cel.24223
ProteinModelPortal Q09499
SMR Q09499
STRING 6239.C41C4.4
PaxDb Q09499
EnsemblMetazoa C41C4.4a
GeneID 174305
KEGG cel:CELE_C41C4.4
UCSC C41C4.4
CTD 174305
WormBase C41C4.4a
eggNOG COG0515
GeneTree ENSGT00390000015684
HOGENOM HOG000012929
InParanoid Q09499
KO K08852
OMA YVWQREG
PhylomeDB Q09499
Reactome REACT_253408
SignaLink Q09499
NextBio 883446
PRO PR:Q09499
Proteomes UP000001940
ExpressionAtlas Q09499
GO GO:0030176
GO:0005524
GO:0004521
GO:0004674
GO:0030968
GO:0002119
GO:0090305
GO:1902255
GO:0006990
GO:0006468
GO:0035966
GO:0090502
GO:0030969
Gene3D 2.140.10.10
InterPro IPR010513
IPR011009
IPR018391
IPR002372
IPR000719
IPR006567
IPR027295
IPR011047
IPR008271
Pfam PF00069
PF01011
PF06479
SMART SM00564
SM00580
SUPFAM SSF50998
SSF56112
PROSITE PS51392
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0002119

nematode larval development

PMID:11779465[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00003970

P

Seeded From UniProt

complete

GO:0003824

catalytic activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

GO:0004521

endoribonuclease activity

PMID:11779465[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O75460

F

Seeded From UniProt

complete

GO:0004540

ribonuclease activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010513

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:11779465[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O75460

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005783

endoplasmic reticulum

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

GO:0006397

mRNA processing

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010513

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:11779465[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O75460

P

Seeded From UniProt

complete

GO:0006986

response to unfolded protein

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0834

P

Seeded From UniProt

complete

GO:0006990

positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

PMID:18216284[2]

IGI: Inferred from Genetic Interaction

WB:WBGene00017244

P

Seeded From UniProt

complete

GO:0006990

positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

PMID:18216284[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008152

metabolic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0030176

integral component of endoplasmic reticulum membrane

PMID:11779465[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O75460

C

Seeded From UniProt

complete

GO:0030968

endoplasmic reticulum unfolded protein response

PMID:11779465[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00003970

P

Seeded From UniProt

complete

GO:0030968

endoplasmic reticulum unfolded protein response

PMID:11779465[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00274962

P

Seeded From UniProt

complete

GO:0030968

endoplasmic reticulum unfolded protein response

PMID:11780124[3]

IMP: Inferred from Mutant Phenotype

WB:WBVar00275456

P

Seeded From UniProt

complete

GO:0030969

mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response

PMID:11779465[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00274962

P

Seeded From UniProt

complete

GO:0035966

response to topologically incorrect protein

PMID:23335331[4]

IGI: Inferred from Genetic Interaction

WB:WBGene00002004

P

Seeded From UniProt

complete

GO:0035966

response to topologically incorrect protein

PMID:23335331[4]

IMP: Inferred from Mutant Phenotype

WB:WBVar00274962

P

Seeded From UniProt

complete

GO:0090305

nucleic acid phosphodiester bond hydrolysis

PMID:11779465[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O75460

P

Seeded From UniProt

complete

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010513

P

Seeded From UniProt

complete

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

PMID:11779465[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O75460

P

Seeded From UniProt

complete

GO:1902255

positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

PMID:25340700[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Shen, X et al. (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107 893-903 PubMed GONUTS page
  2. 2.0 2.1 Uccelletti, D et al. (2008) APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses. Mol. Biol. Cell 19 1337-45 PubMed GONUTS page
  3. Calfon, M et al. (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415 92-6 PubMed GONUTS page
  4. 4.0 4.1 Schipanski, A et al. (2013) A novel interaction between aging and ER overload in a protein conformational dementia. Genetics 193 865-76 PubMed GONUTS page
  5. Levi-Ferber, M et al. (2014) It's all in your mind: determining germ cell fate by neuronal IRE-1 in C. elegans. PLoS Genet. 10 e1004747 PubMed GONUTS page