GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

CAEEL:CED9

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) ced-9
Protein Name(s) Apoptosis regulator ced-9

Cell death protein 9

External Links
UniProt P41958
EMBL L26545
Z29443
PIR A53189
H88578
RefSeq NP_499284.1
UniGene Cel.6305
PDB 1OHU
1TY4
2A5Y
PDBsum 1OHU
1TY4
2A5Y
ProteinModelPortal P41958
SMR P41958
BioGrid 533094
DIP DIP-250N
IntAct P41958
MINT MINT-1526902
STRING 6239.T07C4.8
TCDB 1.A.21.2.1
PaxDb P41958
PRIDE P41958
EnsemblMetazoa T07C4.8
GeneID 3565776
KEGG cel:CELE_T07C4.8
UCSC T07C4.8.1
CTD 3565776
WormBase T07C4.8
eggNOG NOG326862
HOGENOM HOG000111534
InParanoid P41958
OMA TMATSEM
OrthoDB EOG764748
PhylomeDB P41958
EvolutionaryTrace P41958
NextBio 957817
Proteomes UP000001940
GO GO:0012505
GO:0016020
GO:0005741
GO:0005739
GO:0031090
GO:0048471
GO:0005096
GO:0046982
GO:0042803
GO:0097192
GO:0008630
GO:0043066
GO:2001243
GO:0043069
GO:0043547
GO:0010636
InterPro IPR002475
IPR020717
IPR003093
IPR026298
PANTHER PTHR11256
Pfam PF00452
PF02180
SMART SM00265
PROSITE PS50062
PS01080
PS50063

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006915

apoptotic process

PMID:10101135[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P30429,UniProtKB:P42573

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:11226309[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:11226309[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(WBbt:0005784)
  • happens_during:(GO:0050829)

Seeded From UniProt

complete

involved_in

GO:1905516

positive regulation of fertilization

PMID:19575016[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9TZP5

P

Seeded From UniProt

complete

involved_in

GO:1905808

positive regulation of synapse pruning

PMID:26074078[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q21253

P

  • happens_during:(GO:0002119)
  • occurs_in:(WBbt:0005399)

Seeded From UniProt

complete

involved_in

GO:0050807

regulation of synapse organization

PMID:26074078[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q1ZXS6

P

  • happens_during:(GO:0002119)
  • occurs_in:(WBbt:0005399)

Seeded From UniProt

complete

involved_in

GO:0030042

actin filament depolymerization

PMID:26074078[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

PMID:26074078[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0098793

presynapse

PMID:26074078[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0040019

positive regulation of embryonic development

PMID:18776901[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:G5ECW5

P

Seeded From UniProt

complete

involved_in

GO:0040019

positive regulation of embryonic development

PMID:18776901[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901046

positive regulation of oviposition

PMID:18776901[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901046

positive regulation of oviposition

PMID:18776901[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:G5ECW5

P

Seeded From UniProt

complete

involved_in

GO:0016485

protein processing

PMID:19575016[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090727

positive regulation of brood size

PMID:19575016[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1905808

positive regulation of synapse pruning

PMID:26074078[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • happens_during:(GO:0002119)
  • occurs_in:(WBbt:0005399)

Seeded From UniProt

complete

involved_in

GO:0000422

autophagy of mitochondrion

PMID:25896323[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:9027313[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043069

negative regulation of programmed cell death

PMID:9384385[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:11027303[9]

ECO:0000316

genetic interaction evidence used in manual assertion

WB:WBGene00001170

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:11027303[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

WB:WBVar00090305

P

Seeded From UniProt

complete

part_of

GO:0031090

organelle membrane

PMID:9027313[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:9027313[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010636

positive regulation of mitochondrial fusion

PMID:18827010[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(WBbt:0006804)
  • happens_during:(WBls:0000041)

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:17703231[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:12672828[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:10688797[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:18827010[10]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:O00429)

Seeded From UniProt

complete

involved_in

GO:1902742

apoptotic process involved in development

PMID:22801495[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

happens_during:(GO:0009790)

Seeded From UniProt

complete

involved_in

GO:0016485

protein processing

PMID:18776901[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000135647
UniProtKB:P10415
UniProtKB:Q07817
ZFIN:ZDB-GENE-010730-1

P

Seeded From UniProt

complete

involved_in

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101769
MGI:MGI:108052
MGI:MGI:1097161
MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
UniProtKB:Q07820

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
RGD:2192
RGD:2199
RGD:2200
RGD:620525
RGD:620621
RGD:620717
RGD:621635
RGD:70984
UniProtKB:P10415
UniProtKB:Q07812
UniProtKB:Q07820
UniProtKB:Q16611
UniProtKB:Q92843
ZFIN:ZDB-GENE-000511-7
ZFIN:ZDB-GENE-030825-1
ZFIN:ZDB-GENE-051012-1

F

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101769
MGI:MGI:102687
MGI:MGI:88138
MGI:MGI:88139
PANTHER:PTN000135647
RGD:2199
RGD:2200
RGD:620525
UniProtKB:P10415
UniProtKB:Q07817
UniProtKB:Q07820
UniProtKB:Q92843
WB:WBGene00000423
ZFIN:ZDB-GENE-000511-7
ZFIN:ZDB-GENE-010730-1

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1330841
MGI:MGI:1858494
MGI:MGI:99702
PANTHER:PTN000135648
RGD:621635
UniProtKB:P10415
UniProtKB:Q07812
UniProtKB:Q16611

F

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029131
MGI:MGI:101769
MGI:MGI:1097161
MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
RGD:2192
RGD:2200
UniProtKB:P10415
UniProtKB:Q07817
WB:WBGene00000423

C

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003093
InterPro:IPR020717
InterPro:IPR026298
InterPro:IPR036834

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770
UniProtKB-SubCell:SL-0258

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0171

C

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0197

C

Seeded From UniProt

complete

part_of

GO:0012505

endomembrane system

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0147

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Wu, D et al. (1999) C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death. Development 126 2021-31 PubMed GONUTS page
  2. ↑ 2.0 2.1 Aballay, A & Ausubel, FM (2001) Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing. Proc. Natl. Acad. Sci. U.S.A. 98 2735-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Geng, X et al. (2009) Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Cell Death Differ. 16 1385-94 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Meng, L et al. (2015) The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons. Cell Rep 11 1737-48 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Geng, X et al. (2008) Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Nat. Struct. Mol. Biol. 15 1094-101 PubMed GONUTS page
  6. ↑ Palikaras, K et al. (2015) Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature 521 525-8 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Wu, D et al. (1997) Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275 1126-9 PubMed GONUTS page
  8. ↑ Xue, D & Horvitz, HR (1997) Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor. Nature 390 305-8 PubMed GONUTS page
  9. ↑ 9.0 9.1 Parrish, J et al. (2000) Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors. Proc. Natl. Acad. Sci. U.S.A. 97 11916-21 PubMed GONUTS page
  10. ↑ 10.0 10.1 Tan, FJ et al. (2008) CED-9 and mitochondrial homeostasis in C. elegans muscle. J. Cell. Sci. 121 3373-82 PubMed GONUTS page
  11. ↑ Tan, FJ et al. (2007) Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain. Cell Death Differ. 14 1925-35 PubMed GONUTS page
  12. ↑ Senoo-Matsuda, N et al. (2003) A complex II defect affects mitochondrial structure, leading to ced-3- and ced-4-dependent apoptosis and aging. J. Biol. Chem. 278 22031-6 PubMed GONUTS page
  13. ↑ Chen, F et al. (2000) Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science 287 1485-9 PubMed GONUTS page
  14. ↑ Denning, DP et al. (2012) Programmed elimination of cells by caspase-independent cell extrusion in C. elegans. Nature 488 226-30 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 15.3 15.4 15.5 15.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=CAEEL:CED9&oldid=5953519"