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BOVIN:ITPR1

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Species (Taxon ID) Bos taurus (Bovine). (9913)
Gene Name(s) ITPR1
Protein Name(s) Inositol 1,4,5-trisphosphate receptor type 1

IP3 receptor isoform 1 IP3R 1 InsP3R1 Type 1 inositol 1,4,5-trisphosphate receptor Type 1 InsP3 receptor

External Links
UniProt Q9TU34
EMBL AF157625
PIR A38318
RefSeq NP_777266.1
UniGene Bt.22305
ProteinModelPortal Q9TU34
SMR Q9TU34
PRIDE Q9TU34
GeneID 317697
KEGG bta:317697
CTD 3708
eggNOG NOG280601
HOGENOM HOG000007660
HOVERGEN HBG052158
InParanoid Q9TU34
KO K04958
NextBio 20807145
Proteomes UP000009136
GO GO:0005789
GO:0016021
GO:0030658
GO:0005220
GO:0005218
GO:0035091
GO:0048016
GO:0070059
GO:0051209
Gene3D 1.25.10.30
InterPro IPR016024
IPR014821
IPR000493
IPR005821
IPR016093
IPR013662
IPR000699
IPR015925
PANTHER PTHR13715
Pfam PF08709
PF00520
PF02815
PF08454
PF01365
PRINTS PR00779
SMART SM00472
SUPFAM SSF100909
SSF48371
SSF82109
PROSITE PS50919

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030141

secretory granule

PMID:11584008[1]

ECO:0000314

C

Fig. 2

complete
CACAO 3606

GO:0005791

rough endoplasmic reticulum

PMID:11584008[1]

ECO:0000314

C

The bovine adrenal medullary chromaffin cells were immunolabeled for type 1, 2, and 3 IP3R (10 nm) with each isoform-specific affinity-purified IP3R antibodies. As seen in figure 2A, the gold particles are also localized in the rough endoplasmic reticulum (rer as seen in the picture).

complete
CACAO 4040

part_of

GO:0030424

axon

PMID:1311032[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0002037)

Seeded From UniProt

complete

part_of

GO:0098793

presynapse

PMID:1311032[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030176

integral component of endoplasmic reticulum membrane

PMID:1311032[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005791

rough endoplasmic reticulum

PMID:11584008[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

PMID:11584008[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11881

P

Seeded From UniProt

complete

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11881

P

Seeded From UniProt

complete

enables

GO:0035091

phosphatidylinositol binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11881

F

Seeded From UniProt

complete

enables

GO:0005220

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11881

F

Seeded From UniProt

complete

enables

GO:0015278

calcium-release channel activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11881

F

Seeded From UniProt

complete

enables

GO:0070679

inositol 1,4,5 trisphosphate binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001010185
RGD:2934
RGD:69649
UniProtKB:Q14573

F

Seeded From UniProt

complete

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010051
MGI:MGI:96623
MGI:MGI:99659
PANTHER:PTN001416417
RGD:1586637
RGD:2933
RGD:69649
UniProtKB:P21817
UniProtKB:Q92736

P

Seeded From UniProt

complete

enables

GO:0035091

phosphatidylinositol binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96623
MGI:MGI:96624
MGI:MGI:99418
PANTHER:PTN001010185

F

Seeded From UniProt

complete

part_of

GO:0030667

secretory granule membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001010185
RGD:2933
UniProtKB:Q8WN96

C

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000346459
dictyBase:DDB_G0292564

C

Seeded From UniProt

complete

part_of

GO:0016529

sarcoplasmic reticulum

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96623
MGI:MGI:99418
PANTHER:PTN001010185
RGD:2933
RGD:69649

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001416417
RGD:2933
RGD:620314
UniProtKB:P21817
UniProtKB:Q14571
UniProtKB:Q14573

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96623
MGI:MGI:96624
PANTHER:PTN001010185
RGD:2933
RGD:2934
RGD:69649
UniProtKB:Q14573

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001416417
RGD:2934
RGD:69649

F

Seeded From UniProt

complete

enables

GO:0005220

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010051
MGI:MGI:96623
MGI:MGI:96624
MGI:MGI:99418
PANTHER:PTN001010185
RGD:2933
RGD:2934
RGD:69649
UniProtKB:Q14573

F

Seeded From UniProt

complete

involved_in

GO:0048016

inositol phosphate-mediated signaling

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005220

P

Seeded From UniProt

complete

involved_in

GO:0048016

inositol phosphate-mediated signaling

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005220

P

Seeded From UniProt

complete

involved_in

GO:0048016

inositol phosphate-mediated signaling

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005220

P

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

F

Seeded From UniProt

complete

enables

GO:0005220

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000493

F

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000699

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000493

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

P

Seeded From UniProt

complete

involved_in

GO:0006816

calcium ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000493
InterPro:IPR015925

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000699
InterPro:IPR005821
InterPro:IPR016093
InterPro:IPR036300

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

P

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000699

P

Seeded From UniProt

complete

enables

GO:0070679

inositol 1,4,5 trisphosphate binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000493

F

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0107

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0006816

calcium ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0109

P

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0107

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0030658

transport vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0245

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Yoo, SH et al. (2001) Localization of three types of the inositol 1,4,5-trisphosphate receptor/Ca(2+) channel in the secretory granules and coupling with the Ca(2+) storage proteins chromogranins A and B. J. Biol. Chem. 276 45806-12 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Takei, K et al. (1992) Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin. J. Neurosci. 12 489-505 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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