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BOVIN:ACON

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Species (Taxon ID) Bos taurus (Bovine). (9913)
Gene Name(s) ACO2
Protein Name(s) Aconitate hydratase, mitochondrial

Aconitase Citrate hydro-lyase

External Links
UniProt P20004
EMBL Z49931
BC102642
PIR S57528
RefSeq NP_776402.1
UniGene Bt.5210
PDB 1ACO
1AMI
1AMJ
1C96
1C97
1FGH
1NIS
1NIT
8ACN
PDBsum 1ACO
1AMI
1AMJ
1C96
1C97
1FGH
1NIS
1NIT
8ACN
ProteinModelPortal P20004
SMR P20004
IntAct P20004
PaxDb P20004
PRIDE P20004
Ensembl ENSBTAT00000008431
GeneID 280976
KEGG bta:280976
CTD 50
eggNOG COG1048
GeneTree ENSGT00760000119287
HOGENOM HOG000224293
HOVERGEN HBG000248
InParanoid P20004
KO K01681
OMA PLKCIIK
OrthoDB EOG74FF06
TreeFam TF300627
Reactome REACT_227707
UniPathway UPA00223
EvolutionaryTrace P20004
NextBio 20805079
Proteomes UP000009136
GO GO:0005739
GO:0005634
GO:0051539
GO:0003994
GO:0005506
GO:0006101
GO:0006099
Gene3D 3.20.19.10
3.30.499.10
3.40.1060.10
InterPro IPR015931
IPR015937
IPR001030
IPR015928
IPR015932
IPR018136
IPR006248
IPR000573
PANTHER PTHR11670
Pfam PF00330
PF00694
PRINTS PR00415
SUPFAM SSF52016
SSF53732
TIGRFAMs TIGR01340
PROSITE PS00450
PS01244

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006101

citrate metabolic process

PMID:1334546[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:1334546[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

PMID:1334546[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

PMID:1334546[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051538

3 iron, 4 sulfur cluster binding

PMID:1334546[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

PMID:1334546[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006101

citrate metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99798

P

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99798

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99KI0

C

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99798

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99KI0

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
PANTHER:PTN000186533
RGD:621360
UniProtKB:P20004

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010100
PANTHER:PTN000186533
RGD:621360
SGD:S000004295
UniProtKB:Q8ZRS8
UniProtKB:Q99798

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
PANTHER:PTN001705783
SGD:S000004295

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010100
MGI:MGI:87880
PANTHER:PTN000186534
PomBase:SPAC24C9.06c
PomBase:SPBP4H10.15
RGD:621360
UniProtKB:P20004

C

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
MGI:MGI:87880
PANTHER:PTN000186533
RGD:621360
SGD:S000004295
UniProtKB:C8VG90
UniProtKB:P20004
UniProtKB:Q4WLN1
UniProtKB:Q8ZRS8
UniProtKB:Q99798

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99KI0
ensembl:ENSMUSP00000023116

C

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99KI0
ensembl:ENSMUSP00000023116

F

Seeded From UniProt

complete

involved_in

GO:0006101

citrate metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99798
ensembl:ENSP00000216254

P

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99798
ensembl:ENSP00000216254

P

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99798
ensembl:ENSP00000216254

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006248

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006248

P

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006248

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.1.3

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0411

F

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0004

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0816
UniPathway:UPA00223

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Kennedy, MC et al. (1992) Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein. Proc. Natl. Acad. Sci. U.S.A. 89 11730-4 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page