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ARATH:P2C56
Contents
Species (Taxon ID) | Arabidopsis thaliana (Mouse-ear cress). (3702) | |
Gene Name(s) | ABI1 | |
Protein Name(s) | Protein phosphatase 2C 56
AtPP2C56 Protein ABSCISIC ACID-INSENSITIVE 1 Protein phosphatase 2C ABI1 PP2C ABI1 | |
External Links | ||
UniProt | P49597 | |
EMBL | U12856 X77116 X78886 AL049483 AL161564 CP002687 AY035073 AY142623 AK226529 | |
PIR | T04263 | |
RefSeq | NP_194338.1 | |
UniGene | At.21332 | |
PDB | 3JRQ 3KDJ 3NMN | |
PDBsum | 3JRQ 3KDJ 3NMN | |
ProteinModelPortal | P49597 | |
SMR | P49597 | |
BioGrid | 14001 | |
DIP | DIP-36706N | |
IntAct | P49597 | |
MINT | MINT-8390807 | |
PRIDE | P49597 | |
EnsemblPlants | AT4G26080.1 | |
GeneID | 828714 | |
KEGG | ath:AT4G26080 | |
TAIR | AT4G26080 | |
eggNOG | COG0631 | |
HOGENOM | HOG000233896 | |
InParanoid | P49597 | |
KO | K14497 | |
OMA | ACEMARK | |
PhylomeDB | P49597 | |
BioCyc | ARA:AT4G26080-MONOMER | |
EvolutionaryTrace | P49597 | |
Proteomes | UP000006548 | |
Genevestigator | P49597 | |
GO | GO:0005737 GO:0005634 GO:0005886 GO:0046872 GO:0019901 GO:0004722 GO:0009738 GO:0009788 GO:0006470 GO:0009787 GO:0010119 GO:0009737 GO:0009409 GO:0009408 | |
Gene3D | 3.60.40.10 | |
InterPro | IPR001932 IPR000222 IPR015655 | |
PANTHER | PTHR13832 | |
Pfam | PF00481 | |
SMART | SM00331 SM00332 | |
SUPFAM | SSF81606 | |
PROSITE | PS01032 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0006470 |
protein dephosphorylation |
ECO:0000314 |
P |
Addition of ABI1 led to dephosphorylation of pSnRK2.6 (Sup. Fig. 1A). When SnRK2.6 was incubated with the catalytic domain of ABI1, the smeared multiple bands (left side of SDS page figure) reduced to a single one corresponding to an apparent molecular mass of ~41kDA (right lane). This result suggests that SnRK2.6 kinase activity may be hindered via inhibition of ABI1. In addition, using spectrophotometric assayfor protein phosphatases, the kinetic parameters fo ABI1-catalyzed dephosphorylation of SnRK2.6 were deteremined (Fig. 1D), exhibiting a highly specific and efficient inhibition activity. |
complete | |||||
GO:0006470 |
protein dephosphorylation |
ECO:0000314 |
P |
Figure 1D shows results of a kinetics experiment that show that ABI1 dephosphorylates phospho-SnRK2.6 in vitro. |
complete | |||||
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000314 |
F |
Figure 1D shows the results of a kinetics experiment that shows that ABI1 cleaves a phosphate off of the phosphoprotein pSnRK2.6 |
complete | |||||
enables |
GO:0019900 |
kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016791 |
phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009737 |
response to abscisic acid |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009788 |
negative regulation of abscisic acid-activated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009788 |
negative regulation of abscisic acid-activated signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010119 |
regulation of stomatal movement |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009788 |
negative regulation of abscisic acid-activated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009787 |
regulation of abscisic acid-activated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009737 |
response to abscisic acid |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009409 |
response to cold |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009409 |
response to cold |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009408 |
response to heat |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004722 |
protein serine/threonine phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009788 |
negative regulation of abscisic acid-activated signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002302327 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002493005 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002493005 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004724 |
magnesium-dependent protein serine/threonine phosphatase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000352745 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004722 |
protein serine/threonine phosphatase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0086361 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004722 |
protein serine/threonine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043169 |
cation binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009738 |
abscisic acid-activated signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Xie, T et al. (2012) Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1. J. Biol. Chem. 287 794-802 PubMed GONUTS page
- ↑ 2.0 2.1 Rodrigues, A et al. (2013) ABI1 and PP2CA phosphatases are negative regulators of Snf1-related protein kinase1 signaling in Arabidopsis. Plant Cell 25 3871-84 PubMed GONUTS page
- ↑ Matsuoka, D et al. (2015) An abscisic acid inducible Arabidopsis MAPKKK, MAPKKK18 regulates leaf senescence via its kinase activity. Plant Mol. Biol. 87 565-75 PubMed GONUTS page
- ↑ Mitula, F et al. (2015) Arabidopsis ABA-Activated Kinase MAPKKK18 is Regulated by Protein Phosphatase 2C ABI1 and the Ubiquitin-Proteasome Pathway. Plant Cell Physiol. 56 2351-67 PubMed GONUTS page
- ↑ 5.0 5.1 Geiger, D et al. (2010) Guard cell anion channel SLAC1 is regulated by CDPK protein kinases with distinct Ca2+ affinities. Proc. Natl. Acad. Sci. U.S.A. 107 8023-8 PubMed GONUTS page
- ↑ Zhang, Y et al. (2008) F-box protein DOR functions as a novel inhibitory factor for abscisic acid-induced stomatal closure under drought stress in Arabidopsis,. Plant Physiol. 148 2121-33 PubMed GONUTS page
- ↑ 7.0 7.1 Mishra, G et al. (2006) A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis. Science 312 264-6 PubMed GONUTS page
- ↑ 8.0 8.1 Moes, D et al. (2008) Nuclear localization of the mutant protein phosphatase abi1 is required for insensitivity towards ABA responses in Arabidopsis. Plant J. 54 806-19 PubMed GONUTS page
- ↑ Finkelstein, RR (1993) Abscisic acid-insensitive mutations provide evidence for stage-specific signal pathways regulating expression of an Arabidopsis late embryogenesis-abundant (lea) gene. Mol. Gen. Genet. 238 401-8 PubMed GONUTS page
- ↑ Gilmour, SJ & Thomashow, MF (1991) Cold acclimation and cold-regulated gene expression in ABA mutants of Arabidopsis thaliana. Plant Mol. Biol. 17 1233-40 PubMed GONUTS page
- ↑ Mantyla, E et al. (1995) Role of Abscisic Acid in Drought-Induced Freezing Tolerance, Cold Acclimation, and Accumulation of LT178 and RAB18 Proteins in Arabidopsis thaliana. Plant Physiol. 107 141-148 PubMed GONUTS page
- ↑ Larkindale, J et al. (2005) Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance. Plant Physiol. 138 882-97 PubMed GONUTS page
- ↑ Leube, MP et al. (1998) ABI1 of Arabidopsis is a protein serine/threonine phosphatase highly regulated by the proton and magnesium ion concentration. FEBS Lett. 424 100-4 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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