ARATH:NHX1

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	NHX1
Protein Name(s)	Sodium/hydrogen exchanger 1 Na(+)/H(+) exchanger 1 NHE-1
External Links
UniProt	Q68KI4
EMBL	AF106324 AF056190 AF510074 AY685183 AF007271 CP002688
PIR	T01804
RefSeq	NP_198067.1
UniGene	At.25435
ProteinModelPortal	Q68KI4
SMR	Q68KI4
BioGrid	18047
TCDB	2.A.36.5.1
PRIDE	Q68KI4
EnsemblPlants	AT5G27150.1
GeneID	832773
KEGG	ath:AT5G27150
GeneFarm	5184
TAIR	AT5G27150
eggNOG	COG0025
HOGENOM	HOG000272718
InParanoid	Q68KI4
OMA	ISCTIIS
PhylomeDB	Q68KI4
Reactome	REACT_239120
Proteomes	UP000006548
Genevestigator	Q68KI4
GO	GO:0005789 GO:0000139 GO:0016021 GO:0000325 GO:0005886 GO:0005774 GO:0005773 GO:0015081 GO:0015385 GO:0048366 GO:0010351 GO:0055075 GO:0006885 GO:0090333 GO:0009651 GO:0035725 GO:0006814
InterPro	IPR006153 IPR018422 IPR029872 IPR004709
PANTHER	PTHR10110 PTHR10110:SF101
Pfam	PF00999
PRINTS	PR01084
TIGRFAMs	TIGR00840

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0090333	regulation of stomatal closure	PMID:22438021^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	AGI_LocusCode:AT3G05030	P	Seeded From UniProt	complete
involved_in	GO:0055075	potassium ion homeostasis	PMID:22438021^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	AGI_LocusCode:AT3G05030	P	Seeded From UniProt	complete
involved_in	GO:0048366	leaf development	PMID:14535887^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0015385	sodium:proton antiporter activity	PMID:11707435^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009651	response to salt stress	PMID:10455050^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14506206^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005773	vacuole	PMID:9990049^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0098719	sodium ion import across plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000011605 UniProtKB:P19634 UniProtKB:P48764	P	Seeded From UniProt	complete
involved_in	GO:0090333	regulation of stomatal closure	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001603945 TAIR:locus:2114810 TAIR:locus:2181246	P	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000011605 SGD:S000002864 TAIR:locus:2041100	P	Seeded From UniProt	complete
involved_in	GO:0051453	regulation of intracellular pH	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1924281 PANTHER:PTN000011605 RGD:3718 UniProtKB:P19634 dictyBase:DDB_G0275711	P	Seeded From UniProt	complete
enables	GO:0015386	potassium:proton antiporter activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1924281 PANTHER:PTN000011605 SGD:S000002864 TAIR:locus:2114810 UniProtKB:Q96T83	F	Seeded From UniProt	complete
enables	GO:0015385	sodium:proton antiporter activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102462 MGI:MGI:105064 MGI:MGI:105075 MGI:MGI:1924281 PANTHER:PTN000011605 RGD:3718 RGD:3719 RGD:3720 RGD:620473 SGD:S000002864 TAIR:locus:2114810 TAIR:locus:2173972 TAIR:locus:2181246 UniProtKB:P19634 UniProtKB:P48764 UniProtKB:Q96T83 WB:WBGene00003730	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11940 MGI:MGI:105064 MGI:MGI:2443511 PANTHER:PTN000011605 RGD:3718 TAIR:locus:2041100 TAIR:locus:2173972 TAIR:locus:2181246 UniProtKB:P19634 UniProtKB:P48764 UniProtKB:Q3YL57 UniProtKB:Q92581	C	Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015299	P	Seeded From UniProt	complete
part_of	GO:0005774	vacuolar membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029872	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029872	C	Seeded From UniProt	complete
involved_in	GO:0006812	cation transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006153 InterPro:IPR018422	P	Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004709 InterPro:IPR029872	P	Seeded From UniProt	complete
involved_in	GO:0006885	regulation of pH	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004709	P	Seeded From UniProt	complete
involved_in	GO:0009651	response to salt stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029872	P	Seeded From UniProt	complete
enables	GO:0015299	solute:proton antiporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006153 InterPro:IPR018422	F	Seeded From UniProt	complete
enables	GO:0015385	sodium:proton antiporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004709	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004709 InterPro:IPR006153 InterPro:IPR018422	C	Seeded From UniProt	complete
involved_in	GO:0055075	potassium ion homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029872	P	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004709 InterPro:IPR006153	P	Seeded From UniProt	complete
part_of	GO:0000325	plant-type vacuole	PMID:10455050^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0015297	antiporter activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0050	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0005773	vacuole	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0926	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0739	P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C	Seeded From UniProt	complete
part_of	GO:0005774	vacuolar membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0271	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Barragán, V et al. (2012) Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis. Plant Cell 24 1127-42 PubMed GONUTS page
↑ Apse, MP et al. (2003) Vacuolar cation/H+ exchange, ion homeostasis, and leaf development are altered in a T-DNA insertional mutant of AtNHX1, the Arabidopsis vacuolar Na+/H+ antiporter. Plant J. 36 229-39 PubMed GONUTS page
↑ Venema, K et al. (2002) The arabidopsis Na+/H+ exchanger AtNHX1 catalyzes low affinity Na+ and K+ transport in reconstituted liposomes. J. Biol. Chem. 277 2413-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Apse, MP et al. (1999) Salt tolerance conferred by overexpression of a vacuolar Na+/H+ antiport in Arabidopsis. Science 285 1256-8 PubMed GONUTS page
↑ Nühse, TS et al. (2003) Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Mol. Cell Proteomics 2 1234-43 PubMed GONUTS page
↑ Gaxiola, RA et al. (1999) The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast. Proc. Natl. Acad. Sci. U.S.A. 96 1480-5 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22438021-1] 1.0 ^1.1 Barragán, V et al. (2012) Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis. Plant Cell 24 1127-42 PubMed GONUTS page

[PMID:14535887-2] Apse, MP et al. (2003) Vacuolar cation/H+ exchange, ion homeostasis, and leaf development are altered in a T-DNA insertional mutant of AtNHX1, the Arabidopsis vacuolar Na+/H+ antiporter. Plant J. 36 229-39 PubMed GONUTS page

[PMID:11707435-3] Venema, K et al. (2002) The arabidopsis Na+/H+ exchanger AtNHX1 catalyzes low affinity Na+ and K+ transport in reconstituted liposomes. J. Biol. Chem. 277 2413-8 PubMed GONUTS page

[PMID:10455050-4] 4.0 ^4.1 Apse, MP et al. (1999) Salt tolerance conferred by overexpression of a vacuolar Na+/H+ antiport in Arabidopsis. Science 285 1256-8 PubMed GONUTS page

[PMID:14506206-5] Nühse, TS et al. (2003) Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Mol. Cell Proteomics 2 1234-43 PubMed GONUTS page

[PMID:9990049-6] Gaxiola, RA et al. (1999) The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast. Proc. Natl. Acad. Sci. U.S.A. 96 1480-5 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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ARATH:NHX1

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