ARATH:ISE2

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	ISE2 (synonyms: EMB25, PDE317)
Protein Name(s)	DExH-box ATP-dependent RNA helicase DExH15 chloroplastic (ECO:0000305) ATP-dependent RNA helicase ISE2 Protein EMBRYO DEFECTIVE 25 Protein INCREASED SIZE EXCLUSION LIMIT 2 Protein PIGMENT DEFECTIVE 317
External Links
UniProt	B9DFG3
EMBL	AC002062 CP002684 AK316759 AF387007
PIR	D96723
RefSeq	NP_177164.1
UniGene	At.35348
ProteinModelPortal	B9DFG3
BioGrid	28564
STRING	3702.AT1G70070.1
iPTMnet	B9DFG3
PaxDb	B9DFG3
PRIDE	B9DFG3
EnsemblPlants	AT1G70070.1
GeneID	843343
Gramene	AT1G70070.1
KEGG	ath:AT1G70070
Araport	AT1G70070
TAIR	locus:2020573
eggNOG	KOG0947 COG4581
HOGENOM	HOG000245391
InParanoid	B9DFG3
OMA	FTPSYGM
OrthoDB	EOG0936011V
PhylomeDB	B9DFG3
PRO	PR:B9DFG3
Proteomes	UP000006548
Genevisible	B9DFG3
GO	GO:0009507 GO:0009570 GO:0010494 GO:0005524 GO:0004004 GO:0003723 GO:0003724 GO:0009793 GO:0031047 GO:0000373 GO:0006397 GO:0010497 GO:0016441 GO:0010501
Gene3D	3.40.50.300
InterPro	IPR011545 IPR014001 IPR001650 IPR027417 IPR012961
Pfam	PF00270 PF08148 PF00271
SMART	SM00487 SM01142 SM00490
SUPFAM	SSF52540
PROSITE	PS51192 PS51194

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0016554	cytidine to uridine editing	PMID:28346704^[1]	ECO:0000315			P	ISE2 in A. thaliana. Figure 2. Loss of ISE2 compromises C-to-U RNA editing at specific sites. 6 sites known to undergo C-to-U editing are monitored, with a marked decrease in editing in cells with silenced ISE2.	complete CACAO 12408
enables	GO:0003723	RNA binding	PMID:26147377^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
	GO:0000373	Group II intron splicing	PMID:28346704^[1]	ECO:0000315			P	ISE2 in A. thaliana. Figure 4. ISE2 is required for splicing of a group II intron in ycf3 transcripts. Verified using qPCR and gel electrophoresis showing an increase in the unspliced variant of the intron.	complete CACAO 12409
involved_in	GO:0006397	mRNA processing	PMID:26147377^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:1901259	chloroplast rRNA processing	PMID:28346704^[1]	ECO:0000315			P	ISE2 in A. thaliana. Figure 5. Loss of ISE2 leads to defects in rRNA processing. With silenced ISE2, aberrant forms of rRNA are visualized with gel electrophoresis when compared to overexpressed ISE2 and control cells.	complete CACAO 12410
involved_in	GO:0000373	Group II intron splicing	PMID:26147377^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009507	chloroplast	PMID:26147377^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016441	posttranscriptional gene silencing	PMID:17601829^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010497	plasmodesmata-mediated intercellular transport	PMID:11874921^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010497	plasmodesmata-mediated intercellular transport	PMID:17601829^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:17601829^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009793	embryo development ending in seed dormancy	PMID:11874921^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009570	chloroplast stroma	PMID:18633119^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009507	chloroplast	PMID:22106293^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009507	chloroplast	PMID:18431481^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003724	RNA helicase activity	PMID:17601829^[3]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F	Seeded From UniProt	complete
part_of	GO:0009507	chloroplast	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0150 UniProtKB-SubCell:SL-0049	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
part_of	GO:0009536	plastid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0934	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0508	P	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Bobik, K et al. (2017) The chloroplast RNA helicase ISE2 is required for multiple chloroplast RNA processing steps in Arabidopsis thaliana. Plant J. PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Carlotto, N et al. (2016) The chloroplastic DEVH-box RNA helicase INCREASED SIZE EXCLUSION LIMIT 2 involved in plasmodesmata regulation is required for group II intron splicing. Plant Cell Environ. 39 165-73 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Kobayashi, K et al. (2007) INCREASED SIZE EXCLUSION LIMIT 2 encodes a putative DEVH box RNA helicase involved in plasmodesmata function during Arabidopsis embryogenesis. Plant Cell 19 1885-97 PubMed GONUTS page
↑ ^4.0 ^4.1 Kim, I et al. (2002) Identification of a developmental transition in plasmodesmatal function during embryogenesis in Arabidopsis thaliana. Development 129 1261-72 PubMed GONUTS page
↑ Rutschow, H et al. (2008) Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Plant Physiol. 148 156-75 PubMed GONUTS page
↑ Burch-Smith, TM et al. (2011) Organelle-nucleus cross-talk regulates plant intercellular communication via plasmodesmata. Proc. Natl. Acad. Sci. U.S.A. 108 E1451-60 PubMed GONUTS page
↑ Zybailov, B et al. (2008) Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. PLoS ONE 3 e1994 PubMed GONUTS page

[PMID:28346704-1] 1.0 ^1.1 ^1.2 Bobik, K et al. (2017) The chloroplast RNA helicase ISE2 is required for multiple chloroplast RNA processing steps in Arabidopsis thaliana. Plant J. PubMed GONUTS page

[PMID:26147377-2] 2.0 ^2.1 ^2.2 ^2.3 Carlotto, N et al. (2016) The chloroplastic DEVH-box RNA helicase INCREASED SIZE EXCLUSION LIMIT 2 involved in plasmodesmata regulation is required for group II intron splicing. Plant Cell Environ. 39 165-73 PubMed GONUTS page

[PMID:17601829-3] 3.0 ^3.1 ^3.2 ^3.3 Kobayashi, K et al. (2007) INCREASED SIZE EXCLUSION LIMIT 2 encodes a putative DEVH box RNA helicase involved in plasmodesmata function during Arabidopsis embryogenesis. Plant Cell 19 1885-97 PubMed GONUTS page

[PMID:11874921-4] 4.0 ^4.1 Kim, I et al. (2002) Identification of a developmental transition in plasmodesmatal function during embryogenesis in Arabidopsis thaliana. Development 129 1261-72 PubMed GONUTS page

[PMID:18633119-5] Rutschow, H et al. (2008) Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Plant Physiol. 148 156-75 PubMed GONUTS page

[PMID:22106293-6] Burch-Smith, TM et al. (2011) Organelle-nucleus cross-talk regulates plant intercellular communication via plasmodesmata. Proc. Natl. Acad. Sci. U.S.A. 108 E1451-60 PubMed GONUTS page

[PMID:18431481-7] Zybailov, B et al. (2008) Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. PLoS ONE 3 e1994 PubMed GONUTS page

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ARATH:ISE2

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